Mechanism by which hyperglycemia inhibits hepatic glucose production in conscious rats: Implications for the pathophysiology of fasting hyperglycemia in diabetes

Journal of Clinical Investigation

Volumn 92, Issue 3, 1993, Pages 1126-1134

  Rossetti, Luciano ^a   Giaccari, Andrea ^b   Barzilai, Nir ^b   Howard, Kathleen ^b   Sebel, Gary ^b   Hu, Meizhu ^b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

Diabetes mellitus; Glucokinase; Gluconeogenesis; Glucose cycling; Glucose 6 phosphatase; Glycogenolysis

Indexed keywords

GLUCOKINASE; GLUCOSE 6 PHOSPHATASE; INSULIN; SOMATOSTATIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; DIABETES MELLITUS; GLUCONEOGENESIS; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; GLYCOGENOLYSIS; HYPERGLYCEMIA; HYPOGLYCEMIA; HYPOINSULINEMIA; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; DIABETES MELLITUS, EXPERIMENTAL; FASTING; GLUCOKINASE; GLUCONEOGENESIS; GLUCOSE; GLUCOSE-6-PHOSPHATASE; GLYCOGEN SYNTHASE; HYPERGLYCEMIA; INSULIN; LIVER; LIVER GLYCOGEN; MALE; PHOSPHORYLASES; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; URIDINE DIPHOSPHATE GLUCOSE;

EID: 0027199061     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116681     Document Type: Article

References (36)

1. 3H]glucose. J. Clin. Invest. 78:1479-86.
2. DeFronzo, R. A. The triumvirate. 1988. B-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes. 37:667-687.
3. 13C nuclear magnetic resonance study. J. Clin. Invest. 90:1323-1327.
4. Consoli, A., N. Nurjhan, J. J. Reilley, D. M. Bier, and J. E. Gench. 1990. Mechanism of increased gluconeogenesis in non-insulin-dependent diabetes mellitus. J. Clin. Invest. 86:2038-2045.
5. Consoli, A., N. Nurjhan, F. Capani, and J. E. Gerich. 1989. Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes. 38:550-557.
6. Zawadzki, J. K., R. R. Wolfe, D. M. Mott, S. Lillioja, B. V. Howard, and C. Bogardus. 1988. Increased rate of Cori cycle in obese subjects with NIDDM and effect of weight reduction. Diabetes. 37:154-159.
7. Diamond, M. P., R. C. Rollins, K. E. Steiner, P. E. Williams, W. W. Lacy, and A. D. Cherrington. 1988. Effect of alanine concentration independent of changes in insulin and glucagon on alanine and glucose homeostasis in the conscious dog. Metab. Clin. Exp. 37:28-33.
8. Jennsen, T., N. Nurjhan, A. Consoli, and J. E. Gerich. 1990. Failure of substrate-induced gluconeogenesis to increase overall glucose appearance in normal humans. J. Clin. Invest. 86:489-497.
9. Jahoor, F., E. J. Peters, and R. R. Wolfe. 1990. The relationship between gluconeogenic substrate supply and glucose production in humans. Am. J. Physiol. 258:E288-E296.
10. Wolfe, R. B., F. Jahoor, and J. H. F. Shaw. 1986. Effect of alanine infusion on glucose and urea production in man. J. Parenter. Enteral Nutr. 11:109-111.
11. Puhakainen, I., V. A. Koivisto, and H. Yki-Jarvinen. 1991. No reduction in total hepatic glucose output by inhibition of gluconeogenesis with ethanol in NIDDM patients. Diabetes. 40:1319-27.
12. Soskin, S., and R. Levine. 1946. Carbohydrate Metabolism. University of Chicago Press, Chicago. 247-263.
13. Glinsman, W. H., E. P. Hern, and A. Lynch. 1969. Intrinsic regulation of glucose output by rat liver. Am. J. Physiol. 216:698-703.
14. Sacca, L., P. E. Hendler, and R. S. Sherwin. 1979. Hyperglycemia inhibits glucose production in man independent of changes in glucoregulatory hormones. J. Clin. Endocrinol. Metabol. 47:1160-1163.
15. Shulman, G. I., J. E. Lijenquist, P. E. Williams, W. W. Lacy, and A. D. Cherrington. 1978. Glucose disposal during insulinopenia somatostatin-treated dogs: the roles of glucose and glucagon. J. Clin. Invest. 62:487-491.
16. Shulman, G. I., W. W. Lacy, J. E. Lijenquist, U. Keller, P. E. Williams, and A. D. Cherrington. 1980. Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog. J. Clin. Invest. 65:496-505.
17. 14C]-glucose. Diabetes. 35:642-648.
18. Ader, M., G. Pacini, Y. J. Ysug, and R. N. Bergman. 1985. Importance of glucose per se to intravenous glucose tolerance: comparison of the minimal model prediction with direct measurements. Diabetes. 34:1092-1103.
19. Karlander, S., A. Roovete, M. Vranic, and S. Efendic. 1986. Glucose and fructose-6-phosphate cycle in humans. Am. J. Physiol. 251:E530-E536.
20. Efendic, S., S. Karlander, and M. Vranic. 1988. Mild type II diabetes markedly increases glucose cycling in the post-absorptive state and during glucose infusion irrespective of obesity. J. Clin. Invest. 81:1953-61.
21. Miyoshi, H., G. I. Shulman, E. J. Peters, M. H. Wolfe, D. Elahi, and R. R. Wolfe. 1988. Hormonal control of substrate cycling in humans. J. Clin. Invest. 81:1545-55.
22. Wajngot, A., A. Kahn, A. Giacca, M. Vranic, and S. Efendic. 1990. Dexamethasone increases glucose cycling, but not glucose production, in healthy subjects. Am. J. Physiol. 259:E626-E632.
23. Giaccari, A., and L. Rossetti. 1992. Predominant role of gluconeogenesis in the hepatic glycogen repletion of diabetic rats. J. Clin. Invest. 89:36-45.
24. Granner, D. K., and T. L. Andreone. 1985. Insulin modulation of gene expression. Diabetes Metab. Rev. 1:139-170.
25. Foglia, V. G. 1944. Caracterhsticas de la diabetes en la rata. Rev. Soc. Argent. Biol. 20:21-37.
26. Bonner-Weir, S., D. F. Trent, and G. C. Weir. 1983. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. J. Clin. Invest. 71:1544-1553.
27. Rossetti, L., and A. Giaccari. 1990. Relative contribution of glycogen synthesis and glycolysis to insulin-mediated glucose uptake: a dose-response euglycemic clamp study in normal and diabetic rats. J. Clin. Invest. 85:1785-1792.
28. Rossetti, L., D. Smith, G. I. Shulman, D. Papachristou, and R. A. DeFronzo. 1987. Correction of hyperglycemia with phlorizin normalizes tissue sensitivity to insulin in diabetic rats. J. Clin. Invest. 79:1510-1515.
29. Rossetti, L., and M. R. Laughlin. 1989. Correction of chronic hyperglycemia with vanadate, but not phlorizin, normalizes in vivo glycogen repletion and in vitro glycogen synthase activity in diabetic skeletal muscle. J. Clin. Invest. 84:892-899.
30. Farrace, S., and L. Rossetti. 1992. Hyperglycemia markedly enhances skeletal muscle glycogen synthase activity in diabetic, but not in normal conscious rats. Diabetes. 41:1453-1463.
31. 14C]glucose. Anal. Biochem. 25:486-499.
32. Rossetti, L., S. Farrace, S. B. Choi, A. Giaccari, L. Sloan, S. Frontoni, and M. S. Katz. 1993. Multiple metabolic effects of calcitonin gene-related peptide (CGRP) in conscious rats: relationship to its regulation of glycogen synthase and adenylate cyclase. Am. J. Physiol. 264:E1-E10.
33. Davidson, A. L., and W. J. Arion. 1987. Factors underlying significant underestimations of glucokinase activity in crude liver extracts: physiological implications of higher cellular activity. Arch. Biochem. Biophys. 253:156-167.
34. Burchell, A., R. Hume, and B. Burchell. 1988. A new microtechnique for the analysis of the human hepatic microsomal glucose-6-phosphatase system. Clin. Chim. Acta. 173:183-192.
35. Michal, G. 1985. Methods of Enzymatic Analysis. Volume VI. N.U. Bergmeyer, editor. VCH Verlagsgesellschaft mbH, Weinheim, FRG. 191-198.
36. Giaccari, A., and L. Rossetti. 1989. Isocratic high-performance liquid chromatographic determination of the concentration and specific radioactivity of phosphoenolpyruvate and uridine diphosphate glucose in tissue extracts. J. Chromatogr. 497:69-78.