Treatment of Colonic and Rectal Adenomas with Sulindac in Familial Adenomatous Polyposis

New England Journal of Medicine

Volumn 328, Issue 18, 1993, Pages 1313-1316

  Giardiello, Francis M ^a   Hamilton, Stanley R ^a   Krush, Anne J ^a   Piantadosi, Steven ^a   Hylind, Linda M ^a   Celano, Paul ^a   Booker, Susan V ^a   Robinson, C Rahj ^a   Offerhaus, G Johan A ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SULINDAC;

ADENOMATOUS POLYP; ADULT; ARTICLE; CLINICAL ARTICLE; COLON ADENOMA; COLON RESECTION; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; MALE; ORAL DRUG ADMINISTRATION; PATIENT COMPLIANCE; PRIORITY JOURNAL; RECTUM ADENOMA; TUMOR REGRESSION; TUMOR VOLUME;

ADENOMATOUS POLYPOSIS COLI; ADULT; DOUBLE-BLIND METHOD; FEMALE; HUMAN; INTESTINAL POLYPS; MALE; RECTAL NEOPLASMS; SULINDAC; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027197062     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199305063281805     Document Type: Article

References (25)

1. Bussey HJR. Familial polyposis coli: family studies, histopathology, differential diagnosis, and results of treatment. Baltimore: Johns Hopkins University Press, 1975.
2. Boland CR, Itzkowitz SH, Kim YS. Colonic polyps and the gastrointestinal polyposis syndromes. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal disease: pathophysiology, diagnosis, management. 4th ed. Philadelphia: W.B. Saunders, 1989:1483-518.
3. Nishisho I, Nakamura Y, Miyoshi Y, Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science 1991; 253:665-669
4. Kinzler KW, Nilbert MC, Su L-K, Identification of FAP locus genes from chromosome 5q21. Science 1991; 253:661-665
5. Groden J, Thliveris A, Samowitz W, Identification and characterization of the familial adenomatous polyposis coli gene. Cell 1991; 66:589-600
6. Joslyn G, Carlson M, Thliveris A, Identification of deletion mutations and three new genes at the familial polyposis locus. Cell 1991; 66:601-613
7. Waddell WR, Loughry RW Sulindac for polyposis of the colon. J Surg Oncol 1983; 24:83-87
8. Waddell WR, Ganser GF, Cerise EJ, Loughry RW Sulindac for polyposis of the colon. Am J Surg 1989; 157:175-179
9. Labayle D, Fischer D, Vielh P, Sulindac causes regression of rectal polyps in familial adenomatous polyposis. Gastroenterology 1991; 101:635-639
10. Rigau J, Pique JM, Rubio E, Planas R, Tarrech JM, Bordas JM Effects of long-term sulindac therapy on colonic polyposis. Ann Intern Med 1991; 115:952-954
11. DeCosse JJ, Miller HH, Lesser ML Effect of wheat fiber and vitamins C and E on rectal polyps in patients with familial adenomatous polyposis. J Natl Cancer Inst 1989; 81:2190-2197
12. O'Brien PC, Fleming TR A multiple testing procedure for clinical trials. Biometrics 1979; 35:549-556
13. Moorghen M, Ince P, Finney KJ, Sunter JP, Appleton DR, Watson AJ A protective effect of sulindac against chemically-induced primary colonic tumors in mice. J Pathol 1988; 156:341-347
14. Pollard M, Luckert PH Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors. Cancer Treat Rep 1980; 64:1323-1327
15. Pollard M, Luckert PH Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine. Science 1981; 214:558-559
16. Pollard M, Luckert PH, Schmidt MA The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat. Cancer Lett 1983; 21:57-61
17. Narisawa T, Sato M, Sano M, Takahashi T Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin. Gann 1982; 73:377-381
18. Narisawa T, Sato M, Tani M, Kudo T, Takahashi T, Goto A Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment. Cancer Res 1981; 41:1954-1957
19. Ross DS, Bitzer D, Roy T, Murphy JE Piroxicam inhibits the growth of an adenocarcinoma isograft in Fischer rats. J Surg Res 1988; 45:249-253
20. Brooks PM, Day RO Nonsteroidal antiinflammatory drugs – differences and similarities. N Engl J Med 1991; 324:1716-1725
21. Hial V, De Mello MC, Horakova Z, Beaven MA Antiproliferative activity of anti-inflammatory drugs in two mammalian cell culture lines. J Pharmacol Exp Ther 1977; 202:446-454
22. Hial V, Horakova Z, Shaff FE, Beaven MA Alteration of tumor growth by aspirin and indomethacin: studies with two transplantable tumors in mouse. Eur J Pharmacol 1976; 37:367-376
23. Bayer BM, Beaven MA Evidence that indomethacin reversibly inhibits cell growth in the G1 phase of the cell cycle. Biochem Pharmacol 1979; 28:441-443
24. Bayer BM, Kruth HS, Vaughan M, Beaven MA Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin. J Pharmacol Exp Ther 1979; 210:106-111
25. Verma AK, Ashendel CL, Boutwell RK Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-0-tetradecanoylphorbol-13-acetate. Cancer Res 1980; 40:308-315