Protein kinase inhibitor, staurosporine, induces a mature neuronal phenotype in SH‐SY5Y human neuroblastoma cells through an α‐, β‐, and ζ‐protein kinase C‐independent pathway

Journal of Cellular Physiology

Volumn 155, Issue 2, 1993, Pages 301-312

  Jalava, Annika ^a   Åkerman, Karl ^a   Heikkilä, Jari ^a  

^a ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

BRYOSTATIN 1; CALCIUM CHANNEL; NEUROMODULIN; NEUROPEPTIDE Y; NORADRENALIN; PROTEIN KINASE C; STAUROSPORINE; TYROSINE 3 MONOOXYGENASE;

ARTICLE; CELL DIFFERENTIATION; GENE EXPRESSION; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NORADRENERGIC SYSTEM; PRIORITY JOURNAL;

ALKALOIDS; CELL AGING; CELL DIFFERENTIATION; GENE EXPRESSION; GENES, FOS; HUMAN; LACTONES; NEUROBLASTOMA; NEURONS; PHENOTYPE; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN KINASES; STAUROSPORINE; SUBCELLULAR FRACTIONS; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; TETRADECANOYLPHORBOL ACETATE; TUMOR CELLS, CULTURED;

EID: 0027193145     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.1041550211     Document Type: Article

References (71)

1. Functional differentiation of a human ganglion‐cell derived neuroblastoma cell line SH‐SY5Y induced by a phorbol ester (TPA)
2. A study of the factors affecting the auminium oxidetrihydroxyindole procedure for the analysis of catecholamines
3. Bryostatin, a non‐phorbol macrocyclic lactone, activates intact human polymorphonuclear leukocytes and binds to the phorbol ester receptor
4. Inositol triphosphate and diacylglycerol: two interacting second messengers
5. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture
6. Multiple neurotransmitter synthesis by human neuroblastoma cell lines and clones
7. The regulation and celllular functions of phosphatidylcholine hydrolysis
8. src kinase activity during neuronal differentiation of cultured human neuroblastoma cells
9. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding
10. Direct activation of calcium‐activated, phospholipid‐dependent protein kinase by tumour‐promoting phorbol esters
11. FBJ murine osteosarcoma virus: Identification and molecular cloning of biologically active proviral DNA
12. Comparison of effects of bryostatin 1 and 2 and 12‐O‐tetradecanoylphorbol‐13‐acetate on protein kinase C activity in A549 human lung carcinoma cells
13. Staurosporine induces protein kinase C agonist effects and maturation of normal and neoplastic mouse keratinocytes in vitro
14. Interleukin‐2 stimulates association of protein kinase C with plasma membrane
15. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
16. Various rat adult tissues express only one major mRNA species from the glyceraldehyde‐3‐phosphate‐dehydrogenase multigenic family
17. Identification and characterization of voltage‐sensitive calcium channels in neuronal clonal cell lines
18. cdc2‐like kinases
19. Development of neuronal polarity: GAP‐43 distringuishes axonal from dendritic growth cones
20. Cholinergic receptors, ion channels, neurotransmitter synthesis, and neurite outgrowth are independently regulated during in vitro differentiation of a human neuroblastoma cell line
21. 2+ indicators with greatly improved fluorescence properties
22. 2+ oscillations in clusters of pancreatic β‐cells exposed to glucose
23. Different regulation of N‐ and c‐myc expression during phorbol ester‐induced maturation of human SH‐SY5Y neuroblastoma cells
24. Staurosporine induces dissolution of microfilament bundles by a protein kinase C‐independent pathway
25. Protein kinase C activation and down‐regulation in relation to phorbol esterinduced differentiation of SH‐SY5Y human neuroblastoma cells
26. 2+ mobilization and cycle AMP in SH‐SY5Y and IMR 32 neuroblastoma cells
27. Isoquinolinesulfonamides, novel and potent inhibitors cyclic nucleotide dependent protein kinase and protein kinase C
28. Hormoneinduced redistribution of calcium‐activated phospholipid‐dependent protein kinase in pituitary gonadotrophs
29. Purification and characterization of three types of protein kinase C from rabbit brain cytosol
30. Decline in c‐myc mRNA expression but not the induction of c‐fos mRNA expression is associated with differentiation of SH‐SY5Y human neuroblastoma cells
31. Effects of bryostatins 1 and 2 on morphological and functional differentiation of SH‐SY5Y human neuroblastoma cells
32. Staurosporine induces a neuronal phenotype in SH‐SY5Y human neuroblastoma cells that resembles that induced by the phorbol ester 12‐O‐tetradecanoyl phorbol‐13 acetate (TPA)
33. Calcium regulation of the neuronal growth cone
34. Protein kinase C as a possible receptor protein of tumorpromoting phorbol esters
35. Proteolytic activation of calcium‐activated, phospholipid‐dependent protein kinase by calcium‐dependent neutral protease
36. Expression of four types of human tyrosine hydroxylase in COS cells
37. Staurosporine both activates and inhibits serine/threonine kinases in human platelets
38. 2+, phospholipid‐dependent protein kinase associated plasma membrane
39. Bryostatin, an activator of the calcium phospholipid‐dependent protein kinase, blocks phorbol ester‐induced differentiation of human promyelocytic leukemia cells HL‐60
40. Intracellular delivery of protein kinase C‐α or ‐ε isoform‐specific antibodies promotes acquisition of a morphologically differentiated phenotype in neuroblastoma cells
41. Elucidation of the rate‐limiting step in norepinephrine biosynthesis in the perfused guinea pig heart
42. Effects of stimulation of muscarinic and of β‐catecholamine receptors on the intracellular distribution of protein kinase C in guinea pig exocrine glands
43. Inhibition of phorbol ester‐induced phenotypic differentiation of HL‐60 cells by 1‐(5‐isoquinolinylsulfonyl)‐2‐methylpiperazine, a protein kinase inhibitor
44. Calcium regulation of neurite elongation and growth cone motility
45. Simultaneous determination of catecholamines and unconjugated 3,4‐dihydroxyphenylacetic acid in brain tissue by ion‐pairing reverse‐phase high‐performance liquid chromatography with electrochemical detection
46. Cloning, characterization and DNA sequence of a human cDNA encoding neuropeptide tyrosine
47. Staurosporine inhibits tyrosine‐specific protein kinas activity of Rous sarcoma virus transforming protein p60
48. Voltagesensitive calcium channels in differentiated neuroblastoma x glioma hybrid (HG108–15) cells: characterization by quin‐2 fluorescence
49. Thee structure, expression, and properties of additional members of the protein kinase C family
50. Protein kinase C ζ subspecies from rat brain: Its structure, expression, and properties
51. Phenotypic changes of human neuroblastoma cells in culture induced by 12‐O‐tetradecanoyl‐phorbol‐13‐acetate
52. Human neuroblastoma cells in culture: A model for neuronal cell differentiation and function
53. Isolation and structure of bryostatin 1
54. Differentiation of neuroblastoma cells in culture
55. 4 pituitary cells
56. 2+ sensitive, phospholipid‐dependent protein kinsase activity in phorbol ester‐treated 3T3 cells
57. Characeristics of a new human neuroblastoma cell line which differentiates in response to cyclic adenosine 3′: 5′‐monophosphate
58. Unique substrate specificity and regulatory properties of PKC‐ϵ: a rationale for diversity
59. Development of a neural phenotypa in differentiating ganglion cell‐derived human neuroblastoma cells
60. Staurosporine‐induced morphological differentiation of human neuroblastoma cells
61. Enzymatic activities during differentiation of the human neuroblastoma cells, LA‐N‐1 and LA‐N‐2
62. Bryostatins: potent, new mitogens that mimic phorbol ester tumor promoters
63. The antiproliferative effects of staurosporine are not exclusively mediated by inhibition of protein kinase C
64. 2+ dependent protein kinase
65. A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression
66. sn‐1,2‐diacylglycerols and phorbol diesters: Uptake, metabolis, and subsequent assimilation of the diacylglycerol metabolites into complex lipids of cultured cells
67. Rapid down‐regulation of protein kinase C and membrane associatition in phorbol ester‐treated leukemia cells
68. Effect of aging on tyrosine hydroxylase protein content and relative number of dopamine nerve terminals in human caudate
69. Synergistic funtions of phorbol ester and calcium in serotonin release from human platelets
70. 2+/calmodulin‐dependent protein kinase II
71. Down‐regulation of protein kinase C is due to an increased rate of degradation