Prevention and Treatment of Traveler's Diarrhea

New England Journal of Medicine

Volumn 328, Issue 25, 1993, Pages 1821-1827

  Wood, Alastair J J ^a   Dupont, Herbert L ^b   Ericsson, Charles D ^b  

^a University of Texas Medical School and School of Public Health ^*

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; ANTIDIARRHEAL AGENT; ORAL REHYDRATION SOLUTION; ANTIINFECTIVE AGENT; BISMUTH SALICYLATE; COTRIMOXAZOLE; DOXYCYCLINE; LOPERAMIDE; MECILLINAM; QUINOLINE DERIVED ANTIINFECTIVE AGENT; SULFAMETHOXAZOLE; TRIMETHOPRIM;

CHILD; COUNSELING; DIARRHEA; FEEDING BEHAVIOR; FEMALE; HUMAN; INFANT; PREGNANCY; PREGNANCY COMPLICATION; REVIEW; TRAVEL; FOOD INTAKE; GASTROINTESTINAL SYMPTOM; INFECTION PREVENTION; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RISK FACTOR; TRAVELLER DIARRHEA;

ANTIBIOTICS; ANTIDIARRHEALS; CHILD; COUNSELING; DIARRHEA; FEMALE; FOOD HABITS; HUMAN; INFANT; PREGNANCY; PREGNANCY COMPLICATIONS; REHYDRATION SOLUTIONS; TRAVEL;

EID: 0027192148     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199306243282507     Document Type: Review

References (72)

1. Gorbach SL, Edelman R, edsTravelers' diarrhea: National Institutes of Health Consensus Development Conference. Rev Infect Dis 1986; 8: Suppl 2: S109-S233
2. Steffen R, Rickenbach M, Wilhelm U, Helminger A, Schar M Health problems after travel to developing countries. J Infect Dis 1987; 156:84-91
3. Steffen R Epidemiologic studies of travelers' diarrhea, severe gastrointestinal infections, and cholera. Rev Infect Dis 1986; 8: Suppl 2: S122-S130
4. Gorbach SL, Kean BH, Evans DG, Evans DJ Jr, Bessudo D Travelers' diarrhea and toxigenic Escherichia coli. N Engl J Med 1975; 292:933-936
5. DuPont HL, Ericsson CD, DuPont MW Emporiatric enteritis: lessons learned from U.S. students in Mexico. Trans Am Clin Climatol Assoc 1985; 97:32-42
6. Mattila L, Siitonen A, Kyronseppa H, Seasonal variation in etiology of travelers' diarrhea. J Infect Dis 1992; 165:385-388
7. Echeverria P, Sack RB, Blacklow NR, Bodhidatta P, Rowe B, McFarland A Prophylactic doxycycline for travelers' diarrhea in Thailand: further supportive evidence of Aeromonas hydrophila as an enteric pathogen. Am J Epidemiol 1984; 120:912-921
8. Taylor DN, Echeverria P Etiology and epidemiology of travelers' diarrhea in Asia. Rev Infect Dis 1986; 8: Suppl 2: S136-S141
9. Mathewson JJ, Johnson PC, DuPont HL, A newly recognized cause of travelers' diarrhea: enteroadherent Escherichia coli. J Infect Dis 1985; 151:471-475
10. Wanger AR, Murray BE, Echeverria P, Mathewson JJ, DuPont HL Enteroinvasive Escherichia coli in travelers with diarrhea. J Infect Dis 1988; 158:640-642
11. Bolivar R, Conklin RH, Vollet JJ, Rotavirus in travelers' diarrhea: study of an adult student population in Mexico. J Infect Dis 1978; 137:324-327
12. Ryder RW, Oquist CA, Greenberg H Traveler's diarrhea in Panamanian tourists in Mexico. J Infect Dis 1981; 144:442-448
13. Johnson PC, Hoy J, Mathewson JJ, Ericsson CD, DuPont HL Occurrence of Norwalk virus infections among adults in Mexico. J Infect Dis 1990; 162:389-393
14. Wright RA, Spencer HC, Brodsky RE, Vernon TM Giardiasis in Colorado: an epidemiologic study. Am J Epidemiol 1977; 105:330-336
15. Jokipii L, Pohjola S, Jokipii AMM Cryptosporidiosis associated with traveling and giardiasis. Gastroenterology 1985; 89:838-842
16. Frachtman RL, Ericsson CD, DuPont HL Seroconversion to Entamoeba histolytica among short-term travelers to Mexico. Arch Intern Med 1982; 142:1299-1299
17. Tjoa WS, DuPont HL, Sullivan P, Location of food consumption and travelers' diarrhea. Am J Epidemiol 1977; 106:61-66
18. Wood LV, Ferguson LE, Hogan P, Incidence of bacterial enteropathogens in foods from Mexico. Appl Environ Microbiol 1983; 46:328-332
19. Deetz TR, Smith EM, Goyal SM, Occurrence of rota- and enteroviruses in drinking and environmental water in a developing nation. Water Res 1984; 18:567-571
20. Vollet JJ, Ericsson CD, Gibson G, Human rotavirus in an adult population with travelers' diarrhea and its relationship to the location of food consumption. J Med Virol 1979; 4:81-87
21. Kean BH The diarrhea of travelers to Mexico: summary of five-year study. Ann Intern Med 1963; 59:605-614
22. DuPont HL, Haynes GA, Pickering LK, Tjoa W, Sullivan P, Olarte J Diarrhea of travelers to Mexico: relative susceptibility of United States and Latin American students attending a Mexican university. Am J Epidemiol 1977; 105:37-41
23. Sack DA, Kaminsky DC, Sack RB, Prophylactic doxycycline for travelers' diarrhea: results of a prospective double-blind study of Peace Corps volunteers in Kenya. N Engl J Med 1978; 298:758-763
24. Sack RB, Froehlich JL, Zulich AW, Prophylactic doxycycline for travelers' diarrhea: results of a prospective double-blind study of Peace Corps volunteers in Morocco. Gastroenterology 1979; 76:1368-1373
25. Sack RB, Santosham M, Froehlich JL, Medina C, Orskov F, Orskov I Doxycycline prophylaxis of travelers' diarrhea in Honduras, an area where resistance to doxycycline is common among enterotoxigenic Escherichia coli. Am J Trop Med Hyg 1984; 33:460-466
26. DuPont HL, Galindo E, Evans DG, Cabada FJ, Sullivan P, Evans DJ Jr Prevention of travelers' diarrhea with trimethoprim-sulfamethoxazole and trimethoprim alone. Gastroenterology 1983; 84:75-80
27. Bandres JC, Mathewson JJ, Ericsson CD, DuPont HL Trimethoprim/sulfamethoxazole remains active against enterotoxigenic Escherichia coli and Shigella species in Guadalajara, Mexico. Am J Med Sci 1992; 303:289-291
28. Murray BE, Alvarado T, Kim K-H, Increasing resistance to trimethoprim-sulfamethoxazole among isolates of Escherichia coli in developing countries. J Infect Dis 1985; 152:1107-1113
29. Johnson PC, Ericsson CD, Morgan DR, DuPont HL, Cabada FJ Lack of emergence of resistant fecal flora during successful prophylaxis of traveler's diarrhea with norfloxacin. Antimicrob Agents Chemother 1986; 30:671-674
30. Wistrom J, Norrby SR, Burman LG, Lundholm R, Jellheden B, Englund G Norfloxacin versus placebo for prophylaxis against travellers' diarrhoea. J Antimicrob Chemother 1987; 20:563-574
31. Rademaker CM, Hoepelman IM, Wolfhagen MJ, Beumer H, Rozenberg Arska M, Verhoef J Results of a double-blind placebo-controlled study using ciprofloxacin for prevention of travelers' diarrhea. Eur J Clin Microbiol Infect Dis 1989; 8:690-694
32. Black FT, Gaarslev K, Orskov F, Mecillinam, a new prophylactic for travellers' diarrhoea: a prospective double-blind study in tourists traveling to Egypt and the Far East. Scand J Infect Dis 1983; 15:189-193
33. Oksanen PJ, Salminen S, Saxelin M, Prevention of travellers' diarrhoea by Lactobacillus GG. Ann Med 1990; 22:53-56
34. de dios Pozo-Olano J, Warram JH Jr, Gomez RG, Cavazos MG Effect of a lactobacilli preparation on traveler's diarrhea: a randomized, double blind clinical trial. Gastroenterology 1978; 74:829-830
35. DuPont HL, Ericsson CD, Johnson PC, Bitsura JAM, DuPont MW, de la Cabada FJ Prevention of travelers' diarrhea by the tablet formulation of bismuth subsalicylate. JAMA 1987; 257:1347-1350
36. Steffen R, DuPont HL, Heusser R, Prevention of travelers' diarrhea by the tablet form of bismuth subsalicylate. Antimicrob Agents Chemother 1986; 29:625-627
37. Graham DY, Estes MK, Gentry LO Double-blind comparison of bismuth subsalicylate and placebo in the prevention and treatment of enterotoxigenic Escherichia coli-induced diarrhea in volunteers. Gastroenterology 1983; 85:1017-1022
38. Kozicki M, Steffen R, Schar M ‘Boil it, cook it, peel it or forget it': does this rule prevent travellers’ diarrhoea? Int J Epidemiol 1985; 14:169-172
39. Merson MH, Morris GK, Sack DA, Travelers' diarrhea in Mexico: a prospective study of physicians and family members attending a congress. N Engl J Med 1976; 294:1299-1305
40. Ericsson CD, Pickering LK, Sullivan P, DuPont HL The role of location of food consumption in the prevention of travelers' diarrhea in Mexico. Gastroenterology 1980; 79:812-816
41. Ericsson CD, Feldman S, Pickering LK, Cleary TG Influence of subsalicylate bismuth on absorption of doxycycline. JAMA 1982; 247:2266-2267
42. Reves RR, Johnson PC, Ericsson CD, DuPont HL A cost-effectiveness comparison of the use of antimicrobial agents for treatment or prophylaxis of travelers' diarrhea. Arch Intern Med 1988; 148:2421-2427
43. Ericsson CD, DuPont HL, Mathewson JJ, West MS, Johnson PC, Bitsura JAM Treatment of traveler's diarrhea with sulfamethoxazole and trimethoprim and loperamide. JAMA 1990; 263:257-261
44. Farthing MJG, DuPont HL, Guandalini S, Keusch GT, Steffen R Treatment and prevention of travellers' diarrhoea. Gastroenterol Int 1992; 5:162-175
45. Wingate DL Acid reduction and recurrent enteritis. Lancet 1990; 335:222-222
46. DuPont HL, Ericsson CD, Johnson PC Chemotherapy and chemoprophylaxis of travelers' diarrhea. Ann Intern Med 1985; 102:260-261
47. Mendelowitz PC, Hoffman RS, Weber S Bismuth absorption and myoclonic encephalopathy during bismuth subsalicylate therapy. Ann Intern Med 1990; 112:140-141
48. Gorbach SL Bismuth therapy in gastrointestinal diseases. Gastroenterology 1990; 99:863-875
49. DuPont HL, Olarte J, Evans DG, Pickering LK, Galindo E, Evans DJ Jr Comparative susceptibility of Latin American and United States students to enteric pathogens. N Engl J Med 1976; 295:1520-1521
50. DuPont HL, Sullivan P, Pickering LK, Haynes G, Ackerman PB Symptomatic treatment of diarrhea with bismuth subsalicylate among students attending a Mexican university. Gastroenterology 1977; 73:715-718
51. Steinhoff MC, Douglas RG Jr, Greenberg HB, Callahan DR Bismuth subsalicylate therapy of viral gastroenteritis. Gastroenterology 1980; 78:1495-1499
52. van Loon FP, Bennish ML, Speelman P, Butler C Double blind trial of loperamide for treating acute watery diarrhoea in expatriates in Bangladesh. Gut 1989; 30:492-495
53. Johnson PC, Ericsson CD, DuPont HL, Morgan DR, Bitsura JAM, Wood LV Comparison of loperamide with bismuth subsalicylate for the treatment of acute travelers' diarrhea. JAMA 1986; 255:757-760
54. DuPont HL, Hornick RB Adverse effect of lomotil therapy in shigellosis. JAMA 1973; 226:1525-1528
55. DuPont HL, Reves RR, Galindo E, Sullivan PS, Wood LV, Mendiola JG Treatment of travelers' diarrhea with trimethoprim/sulfamethoxazole and with trimethoprim alone. N Engl J Med 1982; 307:841-844
56. Ericsson CD, Johnson PC, DuPont HL, Morgan DR, Bitsura JAM, de la Cabada FJ Ciprofloxacin or trimethoprim-sulfamethoxazole as initial therapy for travelers' diarrhea: a placebo-controlled, randomized trial. Ann Intern Med 1987; 106:216-220
57. Wistrom J, Jertborn M, Hedstrom SA, Short-term self-treatment of travellers' diarrhoea with norfloxacin: a placebo-controlled study. J Antimicrob Chemother 1989; 23:905-913
58. DuPont HL, Ericsson CD, Mathewson JJ, Dupont MW Five versus three days ofloxacin therapy of traveler's diarrhea: a placebo-controlled study. Antimicrob Agents Chemother 1992; 36:87-91
59. Taylor DN, Sanchez JL, Candler W, Thornton S, McQueen C, Echeverria P Treatment of travelers' diarrhea: ciprofloxacin plus loperamide compared with ciprofloxacin alone: a placebo-controlled, randomized trial. Ann Intern Med 1991; 114:731-734
60. Petruccelli BP, Murphy GS, Sanchez JL, Treatment of traveler's diarrhea with ciprofloxacin and loperamide. J Infect Dis 1992; 165:557-560
61. Bandres JC, Mathewson JJ, DuPont HL Heat susceptibility of bacterial enteropathogens: implications for the prevention of travelers' diarrhea. Arch Intern Med 1988; 148:2261-2263
62. Dickens DL, DuPont HL, Johnson PC Survival of bacterial enteropathogens in the ice of popular drinks. JAMA 1985; 253:3141-3143
63. Steffen R, van der Linde F, Gyr K, Schar M Epidemiology of diarrhea in travelers. JAMA 1983; 249:1176-1180
64. Okhuysen PC, DuPont HL, Flores Lopez JF, Perez Castell J, Mathewson JJ A comparative study of furazolidone and placebo in addition to oral rehydration in the treatment of acute infantile diarrhea. Scand J Gastroenterol Suppl 1989; 169:39-46
65. Gough A, Barsoum NJ, Mitchell L, McGuire EJ, de la Iglesia FA Juvenile canine drug-induced arthropathy: clinicopathological studies on articular lesions caused by oxolonic and pipemidic acids. Toxicol Appl Pharmacol 1979; 51:177-187
66. DuPont HL, Ericsson CD, DuPont MW, Luna AC, Mathewson JJ A randomized, open-label comparison of nonprescription loperamide and attapulgite in the symptomatic treatment of acute diarrhea. Am J Med 1990; 88: Suppl 6A: 20S-23S
67. Tacket CO, Losonsky G, Link H, Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coli. N Engl J Med 1988; 318:1240-1243
68. Peltola H, Siitonen A, Kyronseppa H, Prevention of travellers' diarrhoea by oral B-subunit/whole-cell cholera vaccine. Lancet 1991; 338:1285-1289
69. Ericsson CD, DuPont HL, Sullivan P, Galindo E, Evans DG, Evans DJ Jr Bicozamycin, a poorly absorbable antibiotic, effectively treats travelers' diarrhea. Ann Intern Med 1983; 98:20-25
70. DuPont HL, Ericsson CD, Mathewson JJ, de la Cabada FJ, Conrad DA Oral aztreonam, a poorly absorbed yet effective therapy for bacterial diarrhea in US travelers to Mexico. JAMA 1992; 267:1932-1935
71. Ericsson CD, DuPont HL, Galindo E, Efficacy of bicozamycin in preventing traveler's diarrhea. Gastroenterology 1985; 88:473-477
72. DuPont HL, Ericsson CD, Mathewson JJ, Marani S, Knellwolf-Cousin A-L, Martinez-Sandoval FG Zaldaride maleate, an intestinal calmodulin inhibitor, in the therapy of travelers' diarrhea. Gastroenterology 1993; 104:709-715