Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent: Specific block of rapidly activating delayed rectifier K+ current by dofetilide

Circulation Research

Volumn 72, Issue 1, 1993, Pages 75-83

  Jurkiewicz, N K ^a   Sanguinetti, M C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

delayed rectifier K+ current; guinea pigs; UK 68,798

Indexed keywords

1 [2 (6 METHYL 2 PYRIDYL)ETHYL] 4 (4 METHYLSULFONYLAMINOBENZOYL)PIPERIDINE; CALCIUM ION; DOFETILIDE; GLIBENCLAMIDE; NISOLDIPINE;

ANIMAL CELL; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; GUINEA PIG; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART MUSCLE POTENTIAL; HEART VENTRICLE; MALE; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0027186122     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.res.72.1.75     Document Type: Article

References (0)