Solubilization and Stabilization of an Anti-HIV Thiocarbamate, NSC 629243, for Parenteral Delivery, Using Extemporaneous Emulsions

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 10, Issue 7, 1993, Pages 1076-1082

  Strickley, Robert G ^a   Anderson, Bradley D ^a  

^a UNIVERSITY OF UTAH   (United States)

Author keywords

AIDS chemotherapy; anti HIV drugs; disulfide exchange; emulsion; oxidation; parenteral formulation; solubilization; stabilization; thiocarbamate; Uniroyal Jr

Indexed keywords

ANTIOXIDANT; ANTIVIRUS AGENT; NSC 629243; UNCLASSIFIED DRUG;

ARTICLE; DISSOLUTION; DRUG DECOMPOSITION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; EMULSION; OXIDATION; SOLUBILIZATION;

ANTIOXIDANTS; ANTIVIRAL AGENTS; BENZOATES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; DRUG STORAGE; EMULSIONS; HIV; INFUSIONS, INTRAVENOUS; LIPIDS; OILS; SOLUBILITY; SOLVENTS; SUPPORT, U.S. GOV'T, P.H.S.; THIOCARBAMATES;

EID: 0027185429     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018935311304     Document Type: Article

References (8)

1. Solubilization and stabilization of an investigational antineoplastic drug (NSC no. 278214) in an intravenous formulation using an emulsion vehicle
2. Stability and solubilization of oxathiin carboxanilide, a novel anti-HIV agent
3. Spectrophotometric method for quantitation of peroxides in sorbitan monooleate and monostearate
4. Solubilization of drugs by cosolvents
5. An intravenous toxicity study of 2-hydroxypropyl-β-cyclodextrin, a useful drug solubilizer, in rats and monkeys
6. Rate of solute transport out of emulsion droplets in micron size range