Retinoid X receptors stimulate and 9-cis retinoic acid inhibits 1,25-dihydroxyvitamin D3-activated expression of the rat osteocalcin gene

Molecular and Cellular Biology

Volumn 13, Issue 9, 1993, Pages 5907-5917

  Macdonald, Paul N ^a   Dowd, Diane R ^b   Nakajima, Shigeo ^a   Galligan, Michael A ^a   Reeder, Mina C ^a   Haussler, Carol A ^a   Ozato, Keiko ^c   Haussler, Mark R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

^b SAINT LOUIS UNIVERSITY   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA;

CALCITRIOL; CELL NUCLEUS RECEPTOR; OSTEOCALCIN; RETINOIC ACID; RETINOID; VITAMIN RECEPTOR;

ANIMAL CELL; ARTICLE; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HELA CELL; HUMAN; IMMUNOREACTIVITY; PRIORITY JOURNAL; REGULATORY MECHANISM;

ANIMAL; CALCITRIOL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HELA CELLS; HUMAN; LIGANDS; OSTEOCALCIN; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CALCITRIOL; RECEPTORS, CELL SURFACE; RECEPTORS, STEROID; RECOMBINANT PROTEINS; RNA, MESSENGER; SUPPORT, U.S. GOV'T, P.H.S.; TRETINOIN;

EID: 0027185416     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.13.9.5907     Document Type: Article

References (48)

1. Baker, A. R., D. P. McDonnell, M. Hughes, T. M. Crisp, D. J. Mangelsdorf, M. R. Haussler, J. W. Pike, J. Shine, and B. W. O'Malley. 1988. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc. Natl. Acad. Sci. USA 85:3294-3298.
2. Bugge, T. H., J. Pohl, O. Lonnoy, and H. G. Stunnenberg. 1992. RXRα, a promiscuous partner of retinoic acid and thyroid hormone receptors. EMBO J. 11:1409-1418.
3. Carlberg, C., I. Bendik, A. Wyss, E. Meier, L. J. Sturzenbecker, J. F. Grippo, and W. Hunziker. 1993. Two nuclear signalling pathways for vitamin D. Nature (London) 361:657-660.
4. 3-response element in the 5′-flanking region of the rat calbindin D-9k gene. Proc. Natl. Acad. Sci. USA 89:603-607.
5. 3. Proc. Natl. Acad. Sci. USA 87:369-373.
6. de The, H., M. del Mar Vivanco-Ruiz, P. Tiollais, H. Stunnenberg, and A. Dejean. 1990. Identification of a retinoic acid responsive element in the retinoic acid receptor β gene. Nature (London) 343:177-180.
7. Dowd, D. R., and R. L. Miesfeld. 1992. Evidence that glucocorticoid- and cyclic AMP-induced apoptotic pathways in lymphocytes share distal events. Mol. Cell. Biol. 12:3600-3608.
8. Flink, I. L., and E. Morkin. 1990. Interaction of thyroid hormone receptors with strong and weak cis-acting elements in the human α-myosin heavy chain gene promoter. J. Biol. Chem. 265:11233-11237.
9. Glass, C. K., O. V. Devary, and M. G. Rosenfeld. 1990. Multiple cell-type specific proteins differentially regulate target sequence recognition by the α retinoic acid receptor. Cell 63:729-738.
10. Hamada, K., S. L. Gleason, B.-Z. Levi, S. Hirschfeld, E. Appella, and K. Ozato. 1989. H-2RIIBP, a member of the nuclear receptor superfamily that binds to both the regulatory element of major histocompatibility class I genes and the estrogen response element. Proc. Natl. Acad. Sci. USA 86: 8289-8293.
11. Haussler, M. R., C. M. Terpening, B. S. Komm, G. K. Whitfield, and C. A. Haussler. 1988. Vitamin D hormone receptors: structure, regulation and molecular function, p. 205-214. In A. W. Norman, K. Schaefer, H.-G. Grigoleit, and D. V. Herrath (ed.), Vitamin D: molecular, cellular and clinical endocrinology. de Gruyter, Berlin.
12. Heyman, R. A., D. J. Mangelsdorf, J. A. Dyck, R. B. Stein, G. Eichele, R. M. Evans, and C. Thaller. 1992. 9-Cis retinoic acid is a high affinity ligand for the retinoid X receptor. Cell 68:397-406.
13. Hsieh, J.-C., P. W. Jurutka, M. A. Galligan, C. M. Terpening, C. A. Haussler, D. S. Samuels, Y. Shimizu, N. Shimizu, and M. R. Haussler. 1991. Human vitamin D receptor is selectively phosphorylated by protein kinase C on serine 51, a residue crucial to its trans-activation function. Proc. Natl. Acad. Sci. USA 88:9315-9319.
14. 3. Proc. Natl. Acad. Sci. USA 86:4455-4459.
15. Klein-Hitpass, L., S. Y. Tsai, N. L. Weigel, G. F. Allan, D. Riley, R. Rodriguez, W. T. Schrader, M.-J. Tsai, and B. W. O'Malley. 1990. The progesterone receptor stimulates cell-free transcription by enhancing the formation of a stable preinitiation complex. Cell 60:247-257.
16. Kliewer, S. A., K. Umesono, R. A. Heyman, D. J. Mangelsdorf, J. A. Dyck, and R. M. Evans. 1992. Retinoid X receptor-COUP-TF interactions modulate retinoic acid signaling. Proc. Natl. Acad. Sci. USA 89:1448-1452.
17. 3 signalling. Nature (London) 355:446-449.
18. Kliewer, S. A., K. Umesono, D. J. Noonan, R. A. Heyman, and R. M. Evans. 1992. Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors. Nature (London) 358: 771-774.
19. Kumar, V., and P. Chambon. 1988. The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156.
20. Leid, M., P. Kastner, H. Nakshatri, M. Saunders, T. Zacharewski, J.-Y. Chen, A. Staub, J.-M. Garnier, S. Mader, and P. Chambon. 1992. Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently. Cell 68:377-395.
21. Levin, A. A., L. J. Sturzenbecker, S. Kazmer, T. Bosakowski, C. Huselton, G. Allenby, J. Speck, C. L. Kratzeisen, M. Rosenberger, A. Lovey, and J. F. Grippo. 1992. 9-Cis retinoic acid stereoisomer binds and activates the nuclear receptor RXRα. Nature (London) 355:359-361.
22. 3. Proc. Natl. Acad. Sci. USA 87:9751-9755.
23. MacDonald, P. N., C. A. Haussler, C. M. Terpening, M. A. Galligan, M. C. Reeder, G. K. Whitfleld, and M. R. Haussler. 1991. Baculovirus-mediated expression of the human vitamin D receptor. Functional characterization, vitamin D response element interactions and evidence for a receptor auxiliary factor. J. Biol. Chem. 266:18808-18813.
24. Mangelsdorf, D. J., J. W. Pike, and M. R. Haussler. 1987. Avian and mammalian receptors for 1,25-dihydroxyvitamin D3: in vitro translation to characterize size and hormone-dependent regulation. Proc. Natl. Acad. Sci. USA 84:354-358.
25. Mangelsdorf, D. M., U. Borgmeyer, R. A. Heyman, J. Y. Zhou, E. S. Ong, A. E. Oro, A. Kakizuka, and R. M. Evans. 1992. Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 6:329-344.
26. Manley, J. L., A. Fire, M. Samuels, and P. A. Sharp. 1983. In vitro transcription: whole-cell extract. Methods Enzymol. 101: 568-582.
27. Marks, M. S., P. L. Hallenbeck, T. Nagata, J. H. Segars, E. Appella, V. M. Nikodem, and K. Ozato. 1992. H-2RIIBP (RXRβ) heterodimerization provides a mechanism for combinatorial diversity in the regulation of retinoic acid and thyroid hormone responsive genes. EMBO J. 11:1419-1435.
28. Marks, M. S., B.-Z. Levi, J. H. Segars, P. H. Driggers, S. Hirschfeld, T. Nagata, E. Appelle, and K. Ozato. 1992. H-2R-IIBP expressed from a baculovirus vector binds to multiple hormone response elements. Mol. Endocrinol. 6:219-230.
29. McDonnell, D. P., D. J. Mangelsdorf, J. W. Pike, M. R. Haussler, and B. W. O'Malley. 1987. Molecular cloning of complementary DNA encoding the avian receptor for vitamin D. Science 235:1214-1217.
30. 3 receptor. J. Bone Miner. Res. 7:441-448.
31. Morrison, N. A., J. Shine, J.-C. Fragonas, V. Verkest, L. McMenemy, and J. A. Eisman. 1989. 1,25-Dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene. Science 246:1158-1161.
32. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. USA 87:9995-9999.
33. Ozono, K., J. Liao, S. A. Kerner, R. A. Scott, and J. W. Pike. 1990. The vitamin D-responsive element in the human osteocalcin gene. J. Biol. Chem. 265:21881-21888.
34. 3 binding in rat osteosarcoma cells. J. Biol. Chem. 259:8274-8280.
35. Rosen, E. D., A. L. O'Donnell, and R. J. Koenig. 1992. Ligand-dependent synergy of thyroid hormone and retinoid X receptors. J. Biol. Chem. 267:22010-22013.
36. 3 receptor to its response elements. Proc. Natl. Acad. Sci. USA 89:256-260.
37. Seiden, R. F., K. B. Howie, M. E. Rowe, H. M. Goodman, and D. D. Moore. 1986. Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol. Cell. Biol. 6:3173-3179.
38. Shapiro, D. J., P. A. Sharp, W. W. Wahli, and M. J. Keller. 1988. A high-efficiency HeLa cell nuclear transcription extract. DNA 7:47-55.
39. 3-modulated heterodimer. J. Biol. Chem. 266:23296-23305.
40. Sone, T., K. Ozono, and J. W. Pike. 1991. A 55-kilodalton accessory factor facilitates vitamin D receptor DNA binding. Mol. Endocrinol. 5:1578-1586.
41. Summers, M., and G. E. Smith. 1987. A manual of methods for baculovirus vector and insect cell culture procedures, p. 1-57. Texas Agriculture Experimental Station and Texas A & M University, College Station, Tex.
42. Terpening, C. M., C. A. Haussler, P. W. Jurutka, M. A. Galligan, B. S. Komm, and M. R. Haussler. 1991. The vitamin D-responsive element in the rat bone gla protein is an imperfect direct repeat that cooperates with other cis-elements in 1,25-dihydroxyvitamin D3-mediated transcriptional activation. Mol. Endocrinol. 5:373-385.
43. Tsai, S. Y., J. Carlstedt-Duke, N. L. Weigel, K. Dahlman, J.-A. Gustafsson, M.-J. Tsai, and B. W. O'Malley. 1988. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Cell 55:361-369.
44. Umesono, K., K. K. Murakami, C. C. Thompson, and R. M. Evans. 1991. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D receptors. Cell 65:1255-1266.
45. Wrange, O., P. Eriksson, and T. Perlmann. 1989. The purified activated glucocorticoid receptor is a homodimer. J. Biol. Chem. 264:5253-5259.
46. Yu, V. C., C. Delsert, B. Andersen, J. M. Holloway, O. V. Devary, A. M. Naar, S. Y. Kim, J.-M. Boutin, C. K. Glass, and M. G. Rosenfeld. 1991. RXRβ: a coregulator that enhances binding of retinoic acid, thyroid hormone, and vitamin D receptors to their cognate response elements. Cell 67:1251-1266.
47. Zhang, X.-K., B. Hoffmann, P. B.-V. Tran, G. Graupner, and M. Pfahl. 1992. Retinoid X receptor is an auxiliary protein for thyroid hormone and retinoic acid receptors. Nature (London) 355:441-446.
48. Zhang, X.-K., J. Lehmann, B. Hoffmann, M. I. Dawson, J. Cameron, G. Graupner, T. Hermann, P. Tran, and M. Pfahl. 1992. Homodimer formation of retinoid X receptor induced by 9-cis retinoic acid. Nature (London) 358:587-591.