Enzymatic synthesis and degradation of anandamide, a cannabinoid receptor agonist

Biochemical Pharmacology

Volumn 46, Issue 5, 1993, Pages 791-796

  Deutsch, Dale G ^a   Chin, Suzette A ^a  

^a STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIDASE; AMIDE; ANANDAMIDE; ARACHIDONIC ACID; BENZYLSULFONYL FLUORIDE; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR AGONIST; ETHANOLAMINE; RADIOISOTOPE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BIOSYNTHESIS; BRAIN; CELL CULTURE; CELL FRACTIONATION; CELL LINE; CONTROLLED STUDY; DEGRADATION; DRUG UPTAKE; ENZYME ACTIVITY; FEMALE; GLIOMA CELL; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDES; ANIMAL; ARACHIDONIC ACID; BRAIN CHEMISTRY; CELL LINE; ETHANOLAMINES; FATTY ACIDS, UNSATURATED; GLIOMA; NEUROBLASTOMA; PHENYLMETHYLSULFONYL FLUORIDE; RATS; RECEPTORS, DRUG; SUBCELLULAR FRACTIONS; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0027180394     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(93)90486-G     Document Type: Article

References (17)

1. Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes
2. Structure of a cannabinoid receptor and functional expression of the cloned cDNA
3. Cannabinoid receptor localization in the brain
4. Distribution of neuronal cannabinoid receptor in the adult rat brain: A comparative receptor binding radioautography and in situ hybridization histochemistry
5. Isolation and structure of a brain constituent that binds to the cannabinoid receptor
6. Behavioral, biochemical and molecular modeling evaluations of cannabinoid analogs
7. Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent
8. Phencyclidine and analogues: Effect on brain protein synthesis
9. Fatty acid amides of ethanolamine in mammalian tissue
10. Synthesis of fatty acid amides
11. Enzymatic formation of fatty acid amides of ethanolamine by rat liver microsomes
12. Microsomal synthesis of fatty acid amides
13. Biosynthesis of N-acylethanolamine phospholipids by dog brain preparations
14. Metabolism of N-acylethanolamine phospholipids by a mammalian phosphodiesterase of the phospholipase D type
15. Properties of rat liver N-acylethanolamine amidohydrolase
16. Enzymatic formation of lipo-amino acids by rat liver preparations and the nature of the product
17. Enzymic hydrolysis and synthesis of ceramides