Tissue disposition, excretion and metabolism of vinblastine in mice as determined by high-performance liquid chromatography

Cancer Chemotherapy and Pharmacology

Volumn 32, Issue 4, 1993, Pages 286-292

  van Tellingen, Olaf ^a   Beijnen, Jos H ^b   Nooijen, Willem J ^a   Bult, Auke ^c  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b SLOTERVAART HOSPITAL   (Netherlands)

^c UTRECHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DEACETYLVINBLASTINE; DRUG METABOLITE; RADIOISOTOPE; VINBLASTINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DISPOSITION; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG FECES LEVEL; DRUG METABOLISM; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FLUORESCENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; CALIBRATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FECES; GASTROINTESTINAL SYSTEM; KIDNEY; LIVER; MALE; MICE; TISSUE DISTRIBUTION; VINBLASTINE;

EID: 0027178308     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/BF00686174     Document Type: Article

References (13)

1. Investigations of the metabolic fate of tritiated vincristine in the rat by high-pressure liquid chromatography
2. Distribution and excretion of [3H]vincristine in the rat and the dog
3. Disposition and tissue levels of [3H]vindesine in rats
4. Distribution and metabolism of vincristine in mice, rats, dogs and monkeys
5. Determinants of intrinsic sensitivity to vinca alkaloids in xenografts of pediatric rhabdomyosarcomas
6. The distribution of [3H]vinblastine in tumor and host tissues of Nb rats bearing a transplantable lymphoma which is highly sensitive to the alkaloid
7. Pharmacokinetics and metabolism of vinblastine in humans
8. In vivo and in vitro pharmacokinetics and metabolism of vinca alkaloids in rat: I. Vindesine (4-deacetyl-vinblastine-3-carboxyamide)
9. High performance liquid chromatography analysis of vinblastine, 4- O-deacetylvinblastine and the potential metabolite 4- O-deacetylvinblastine-3-oic acid in biological fluids
10. Analytical methods for the determination of vinca alkaloids in biological specimens: a survey of the literature
11. Pharmacology, bioanalysis and pharmacokinetics of the vinca alkaloids and semisynthetic derivatives (review)
12. In vivo and in vitro pharmacokinetics and metabolism of vinca alkaloids in rat: II. Vinblastine and vincristine