Multiple sclerosis: Remyelination in acute lesions

Journal of Neuropathology and Experimental Neurology

Volumn 52, Issue 3, 1993, Pages 199-204

  Raine, Cedric S ^a   Wu, Elizabeth ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

CNS remyelination; Multiple sclerosis; Oligodendrocytes

Indexed keywords

ADULT; ARTICLE; ASTROCYTE; ELECTRON MICROSCOPY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MACROPHAGE FUNCTION; MULTIPLE SCLEROSIS; NEUROPATHOLOGY; OLIGODENDROGLIA; PRIORITY JOURNAL; REMYELINIZATION; TISSUE DISTRIBUTION;

ACUTE DISEASE; ADOLESCENT; ADULT; ANTIGENS, CD57; ANTIGENS, DIFFERENTIATION; HUMAN; MIDDLE AGE; MULTIPLE SCLEROSIS; MYELIN SHEATH; OLIGODENDROGLIA; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027173943     PISSN: 00223069     EISSN: 15546578     Source Type: Journal    
DOI: 10.1097/00005072-199305000-00003     Document Type: Article

References (20)

1. Prineas J. The neuropathology of multiple sclerosis. In: Koetsier JC, ed. Handbook of clinical neurology. Amsterdam: Elsevier, 1985: 213-57
2. Raine CS. Demyelinating diseases. In: Davis RL, Robertson DM, eds. Textbook of neuropathology. Baltimore: Williams and Wilkins, 1990:535-620
3. Allen IV, Kirk J. Demyelinating diseases. In: Adams JH, Duchen LW, eds. Greenfield's neuropathology. New York: Oxford Univ. Press, 1992:447-520
4. Raine CS, Scheinberg LC, Waltz JM. Multiple sclerosis: Oligodendrocyte survival and proliferation in an active, established lesion. Lab Invest 1981;45:534-46
5. Wu E, Raine CS. Multiple sclerosis: Interactions between oligodendrocytes and hypertrophic astrocytes and their occurrence in other, non-demyelinating conditions. Lab Invest 1992;67:88-99
6. Prineas JW, Kwon EE, Goldenberg PZ, Ilyas AA, Quarles RH, Benjamins JA, Sprinkle TJ. Multiple sclerosis: Oligodendrocyte proliferation and differentiation in fresh lesions. Lab Invest 1989; 61:489-503
7. Prineas JW, Kwon EE, Goldenberg PZ, Cho ES, Sharer LR. Interaction of astrocytes and newly formed oligodendrocytes in resolving multiple sclerosis lesions. Lab Invest 1990;63:624-36
8. Raine CS, Johnson AB, Marcus D, Suzuki A, Bornstein MB. De-myelination in vitro: Absorption studies demonstrate that galac-tocerebroside is a major target. J Neurol Sci 1981;52:117-31
9. Ghatak NR, Leshner RT, Price AC, Felten WL. Remyelination in the human central nervous system. J Neuropathol Exp Neurol 1989; 48:507-18
10. Ghatak NR. Occurrence of oligodendrocytes within astrocytes in demyelinating lesions. J Neuropathol Exp Neurol 1992;51:40-6
11. Prineas JW, Kwon EE, Sharer LR, Cho ES. Massive early remyelination in acute multiple sclerosis. (Abstract) Neurology 1987; 37(Suppl 1):109
12. Perier O, Gregoire A. Electron microscopic features of multiple sclerosis lesions. Brain 1965;88:937-52
13. Suzuki K, Andrews JM, Waltz JM, Terry RD. Ultrastructural studies of multiple sclerosis. Lab Invest 1969;20:444-54
14. Benveniste EN, Merrill JE. Stimulation of oligodendroglial proliferation and maturation by interleukin-2. Nature 1986;321:610-13
15. Hofman FM, von Hanwehr RI, Dinarello CA, Mizel SB, Hinton D, Merrill JE. Immunoregulatory molecules and IL-2 receptors identified in multiple sclerosis brain. J Immunol 1986; 136:3239-45
16. Saneto RP, Altman A, Knobler RL, Johnson HM, DeVellis J. Interleukin-2 mediates the inhibition of oligodendrocyte progenitor cell proliferation in vitro. Proc Natl Acad Sci USA 1986;83:9221-5
17. Hofman FM, Hinton DR, Johnson K, Merrill JE. Tumor necrosis factor identified in multiple sclerosis brain. J Exp Med 1989; 170: 607-12
18. Selmaj K, Raine CS, Cannclla B, Brosnan CF. Identification of lymphotoxin and tumor necrosis factor in multiple sclerosis lesions. J Clin Invest 1991;87:949-54
19. Selmaj K, Raine CS. Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro. Ann Neurol 1988;23:339-46
20. Selmaj K, Raine CS, Farooq M, Norton WT, Brosnan CF. Cytokine cytotoxicity against oligodendrocytes: Apoptosis induced by lymphotoxin. J Immunol 1991;147:1522-9