The T‐cell response to myelin basic protein in familial multiple sclerosis: Diversity of fine specificity, restricting elements, and T‐cell receptor usage

Annals of Neurology

Volumn 34, Issue 3, 1993, Pages 385-393

  Joshi, Narendra ^a   Usuku, Koichiro ^a   Hauser, Stephen L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA ANTIGEN CLASS 2; HLA DP ANTIGEN; HLA DQ ANTIGEN; HLA DR ANTIGEN; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

ALLERGIC ENCEPHALITIS; ANTIGEN RECOGNITION; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; FAMILIAL DISEASE; FAMILY STUDY; GENETIC PREDISPOSITION; HUMAN; HUMAN CELL; MULTIPLE SCLEROSIS; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL;

ALLELES; CASE REPORT; CELL LINE; CELLS, CULTURED; FEMALE; HAPLOTYPES; HLA-D ANTIGENS; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; PEDIGREE; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES;

EID: 0027170966     PISSN: 03645134     EISSN: 15318249     Source Type: Journal    
DOI: 10.1002/ana.410340313     Document Type: Article

References (59)

1. T cell recognition of myelin basic protein
2. Immunological aspects of demyelinating diseases
3. The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis
4. Adoptive transfer of myelin basic protein‐sensitized T cells produces chronic relapsing demyelinating disease in mice
5. Encephalitogenic T cell clones specific for myelin basic protein. An unusual bias in antigen recognition
6. MHC‐linked control of murine immune response to myelin basic protein
7. The T lymphocyte in experimental allergic encephalomyelitis
8. Predominant expression of a T cell receptor Vβ gene subfamily in autoimmune encephalomyelitis
9. T cell receptor β chain usage in myelin basic protein‐specific rat T lymphocytes
10. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention
11. Immunization with a synthetic T cell receptor V‐region peptide protects against experimental autoimmune encephalomyelitis
12. Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar Vα and Vβ chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different
13. Shared T‐cell receptor gene usage in experimental allergic neuritis and encephalomyelitis
14. T cell recognition as the target of immune intervention in autoimmune disease
15. Antigen recognition in autoimmune encephalomyelitis and the potential for peptidemediated immunotherapy
16. T‐cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis
17. Fine specificity and HLA restriction of myelin basic protein‐specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals
18. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA‐DR2 products by T lymphocytes of multiple sclerosis patients and healthy donors
19. Response of human T lymphocyte lines to myelin basic prote In: association of dominant epitopes with HLA class II restriction molecules
20. T cell response to myelin basic protein epitopes in multiple sclerosis patients and healthy subjects
21. Shared human T cell receptor Vβ usage to immunodominant regions of myelin basic protein
22. Preferential T‐cell receptor β‐chain variable gene use in myelin basic protein‐reactive T‐cell clones from patients with multiple sclerosis
23. Restricted T cell receptor Vβ gene usage by myelin basic protein‐specific T cell clones in multiple sclerosis: predominant genes vary in individuals
24. Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes
25. + cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87–106
26. Diagnostic criteria for multiple sclerosis research involving multiply affected families
27. Large scale preparation of myelin basic protein from central nervous system tissues of several mammalian species
28. The human T‐cell receptor β‐chain repertoire: longitudinal fluctuations and assessment in MHC matched populations
29. Multiple sclerosis sibling pairs: clustered onset and familial predisposition
30. Extended major histocompatibility complex haplotypes in patients with multiple sclerosis
31. A susceptibility locus for multiple sclerosis is linked to the T cell receptor β chain complex
32. The germline repertoire of T cell receptor β‐chain genes in patients with chronic progressive multiple sclerosis
33. DNA length polymorphism 5′ to the myelin basic protein gene is associated with multiple sclerosis
34. Autoreactive T lymphocytes in multiple sclerosis determined by antigen‐induced secretion of interferon‐γ
35. Frequency of T‐cells specific for myelin basic protein and myelin proteolipid protein in blood and cerebrospinal fluid in multiple sclerosis
36. Myelin basic protein‐specific T lymphocytes from MS patients and healthy individuals
37. Myelin basic protein‐specific T lymphocytes in multiple sclerosis and controls: precursor frequency, fine specificity and cytotoxicity
38. A functional basis for the association of HLA class II genes and susceptibility to multiple sclerosis: cellular immune responses to myelin basic protein in a multiplex family
39. Myelin antigen reactive T cells in cerebrovascular diseases
40. A myelin basic protein is recognized by cytotoxic T cells in the context of four HLA‐DR types associated with multiple sclerosis
41. Universally immunogenic T cell epitopes: promiscuous binding to human class II and promiscuous recognition by T cells
42. Failure to detect MHC class II associations of the human immune response induced by repeated malaria infections to the Plasmodium falciparum antigen Pf155/RESA
43. T cell epitope selection: dominance may be determined by both affinity for major histocompatibility complex and stoichiometry of epitope
44. The choice of T‐cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site
45. Constraints in antigen processing result in unresponsiveness to a T cell epitope of hen egg lysozyme in C57BL/6 mice
46. Analysis of TCR Vβ gene usage and encephalitogenicity of myelin basic protein peptide p91–103 reactive T cell clones in SJL mice: lack of evidence for V gene hypothesis
47. Molecular components of T‐cell recognition
48. Limited T‐cell receptor β‐chain heterogeneity among interleukin 2 receptor‐positive synovial T cells suggests a role for superantigen in rheumatoid arthritis
49. In a small multideterminant peptide, each determinant is recognized by a different Vβ gene segment
50. Determinant selection and macrophage function in genetic control of the immune response
51. The T cell receptor
52. Selective decreases in T cell receptor Vβ families is associated with expression of multiple MHC and non‐MHC gene products
53. Effect of polymorphism of an MHC‐linked transporter on the peptides assembled in a class I molecule
54. Allelic variants of the human putative peptide transporter involved in antigen processing
55. Profound alteration in an αβ T‐cell antigen receptor repertoire due to polymorphism in the first complementarity‐determining region of the β chain
56. Nearly identical T‐cell receptor V‐gene usage at birth in two cohorts of distinctly different ethinic origin: influence of environment in the final maturation in the adult
57. Alterations in T cell antigen specificity and class II restriction during the course of chronic relapsing experimental allergic encephalomyelitis
58. Selection for T‐cell receptor Vβ‐Dβ‐Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis