Expression of the multidrug transporter, P‐glycoprotein, in renal and transitional cell carcinomas

Cancer

Volumn 71, Issue 11, 1993, Pages 3611-3619

  Nishiyama, Kenryu ^a   Shirahama, Tsutomu ^a   Yoshimura, Akihiko ^a   Sumizawa, Tomoyuki ^a   Furukawa, Tatsuhiko ^a   Ichikawa‐Haraguchi, Misako ^a   Akiyama, Shin‐Ichi ^a   Ohi, Yoshitada ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

N linked glycosylation; P glycoprotein; renal cell carcinoma; transitional cell carcinoma

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; AZIDOPINE; GLYCOPROTEIN P; MONOCLONAL ANTIBODY; VINCA ALKALOID;

ARTICLE; DRUG BINDING SITE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; KIDNEY CARCINOMA; MOLECULAR WEIGHT; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; PROTEIN GLYCOSYLATION; PROTEIN LOCALIZATION; TRANSITIONAL CELL CARCINOMA;

AFFINITY LABELS; AZIDES; CARCINOMA, RENAL CELL; CARCINOMA, TRANSITIONAL CELL; CARRIER PROTEINS; DIHYDROPYRIDINES; DRUG RESISTANCE; HUMAN; IMMUNOBLOTTING; KIDNEY; KIDNEY NEOPLASMS; MEMBRANE GLYCOPROTEINS; NEOPLASM PROTEINS; P-GLYCOPROTEIN;

EID: 0027164189     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19930601)71:11<3611::AID-CNCR2820711124>3.0.CO;2-T     Document Type: Article

References (36)

1. Active outward transport of daunomycin in resistant Ehrlich ascites tumor cells
2. Reduced permeability in Chinese hamster ovary cells as a mechanism of resistance to colchicine
3. Decreased retention of Adriamycin and daunomycin by sensitive and anthracycline‐resistant sublines of P388 leukemia
4. Reduced drug accumulation in multiply drug‐resistant human KB carcinoma cell lines
5. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
6. Altered surface membrane glycoproteins in Vinca alkaloid resistant human leukemic lymphoblasts
7. Multiple drug‐resistance to colchicine, Adriamycin or vinblastine show changes in expression of specific protein
8. Characteristics of resistance to Adriamycin in human myelogenous leukemia K562 resistant to Adriamycin and in isolated clones
9. The multidrug transporter, a doubleedged sword
10. Mechanism of multidrug resistance
11. Mechanisms of multidrug resistance and implications for therapy
12. Detection of P‐glycoprotein in ovarian cancer: a molecular marker associated with multidrug resistance
13. Detection of multidrug resistance markers, P‐glycoprotein and mdr1 mRNA, in human leukemia cells
14. P‐glycoprotein in human sarcoma: evidence for multidrug resistance
15. Expression of a multidrug‐resistance gene in human tumors and tissues
16. Expression of a multidrug‐resistance gene in human cancers
17. Multidrug resistance in haemopoietic cell lines, myelodysplastic syndromes and acute myeloblastic leukemia
18. Drug‐resistance in multiple myeloma and non‐Hodgkin's lymphoma: detection of P‐glycoprotein and potential circumvention by addition of verapamil to chemotherapy
19. Expression of the multidrug transporter, P‐glycoprotein, in acute leukemia cells and correlation to clinical drug resistance
20. Expression of the multidrug transporter, P‐glycoprotein, in chronic myelogenous leukaemia cells in blast crisis
21. Expression of P‐glycoprotein in adult T‐cell leukemia cells
22. Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug‐resistance gene
23. Measurement of multidrug‐resistance messenger RNA in urogenital cancers: elevated expression in renal cell carcinoma is associated with intrinsic drug resistance
24. MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants
25. Isolation and genetic characterization of human KB cell lines resistant to multiple drugs
26. Detection of P‐glycoprotein in multidrug‐resistant cell lines by monoclonal antibodies
27. Functional role for the 170‐to 180‐kDa glycoprotein specific to drug‐resistant tumor cells as revealed by monoclonal antibodies
28. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein dye binding
29. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
30. Cytoplasmic orientation and two‐domain structure of the multidrug transporter, P‐glycoprotein demonstrated with sequence‐specific antibodies
31. Identification of a membrane glycoprotein overexpression in murine lymphoma sublines resistant to cis‐diamminedichloroplatinum (II)
32. 3H]azidopine photolabeling of P‐glycoprotein by newly synthesized dihydropyridine analogues in a human cell line
33. Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein, P170: evidence for localization in brain capilaries and cross‐reactivity of one antibody with a muscle protein
34. Expression of the mdr1 gene in human gastric and colorectal carcinomas
35. Interaction of organic chemicals with P‐glycoprotein in the adrenal gland, kidney, and a multidrug‐resistant KB cell
36. Glycosylation of P‐glycoprotein in a multidrug‐resistant KB cell line, and in the human tissues