Effect of urosodeoxycholic acid therapy on lymphocyte function of patients with primary biliary cirrhosis

Kanzo

Volumn 34, Issue 4, 1993, Pages 306-312

  Ogino, Hedero ^a   Unoura, Masashi ^a   Kawai, Hiroshi ^a   Terasaki, Shuichi ^a   Yanagi, Masayuki ^a   Matsushita, Eiki ^a   Urabe, Takeshi ^a   Kaneko, Shuichi ^a   Kobayashi, Kenichi ^a   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CHENODEOXYCHOLIC ACID; INTERLEUKIN 2; URSODEOXYCHOLIC ACID;

ADULT; AGED; ARTICLE; AUTOIMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LYMPHOCYTE FUNCTION; MALE; ORAL DRUG ADMINISTRATION; PRIMARY BILIARY CIRRHOSIS;

EID: 0027162937     PISSN: 04514203     EISSN: 18813593     Source Type: Journal    
DOI: 10.2957/kanzo.34.306     Document Type: Article

References (18)

1. Dickson ER, Fleming CR, Ludwig J: Primary biliary cirrhosis. In: Popper H, Schaffner F, eds. Progress in Liver Diseases. vol VI. Grune & Stratton. New York, 1977, p 487-502.
2. Medical Immunology 17 :683-686, 1989.
3. Poupon R, Chretien Y, Poupon RE: Isursodeoxycholic acid an effective treatment for primary biliary cirrhosis Lancet 1 :834-836, 1987.
4. Leuschner U, Fischner H, Kurtz W et al.: Ursodeoxycholic acid in primary biliary cirrhosis: Results of a controlled double-blind trial. Gastroenterology 97:1268-1274, 1989.
5. Matsuzaki Y, Tanaka N, Ousuga T: Improvement of biliary enzyme levels and itching as a result of long-term administration of ursodeoxycholic acid in primary biliary cirrhosis. Am J Gastroenterol 85:15-23, 1990.
6. Winchurch RA, Cimino E: Analysis of variability of in vitro lymphocyte responses as measured by laser cytometory and thymidine incorporation. J Immunol Methods 23 :269-274, 1978.
7. Calmus Y, Gane P, Rouger P et al : Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid. Hepatology 11 :12-15, 1990.
8. Terasaki S, Nakanuma Y, Ogino H et al : Hepatocellular and biliary expression of HLA antigens in primary biliary cirrhosis before and after ursodeoxycholic acid therapy. Am J Gastroenterol 86 :1194-1199, 1991.
9. Sherlock S: Primary Biliary cirrhosis. In: Diseases of the Liver and Biliary System, Edited by Sherlock S, Blackwell Scientific Publications, Oxford, 1989, p 273-288.
10. Tokyo Tanabe Quarterly 1989 : 39-46, 1989.
11. James SP, Jones EA: Abnormal natural killer cytotoxicity in primary biliary cirrhosis: Evidence for a functional deficiency of cytolytic effector cells. Gastroenterology 89 :165-171, 1985.
12. Newberry WM, Shorey JW, Sanford JP et al : Depression of lymphocyte reactivity to phytohemaggulutinin by serum from patients with liver disease. Cell Immunol 6 : 87-97, 1973.
13. Gianni L, Di Padova F, Zuin M et al : Bile acid-induced inhibition of the lymphoproliferative response to phytohemagglutinin and pokeweed mitogen: An in vitro study. Gastroenterology 78 : 231-235, 1980.
14. Hamprecht B, Roscher R, Waltinger G et al : Influence of bile acids on the activity of rat liver3-hydroxy-3-methyl glutaryl coenzyme A reductase. 2. Effect of cholic acid in lymph fistula rats. Eur J Biochem 18 : 15-19, 1971.
15. Calandra S, Tarugi P, Battistini N et al : Cholesterol synthesis in isolated rat hepatocytes. in vitro effect of sterols and bile acids. Exp Mol Pathol 30 :434-448, 1979.
16. Yoshikawa M, Tsujii T, Matsumura K et al : Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 16 :358-364, 1992.
17. Heuman DM, Pandak WM, Hylemon PB et al : Conjugates of ursodeoxycholate protect against cytotoxicity of more hydrophobic bile salts: In vitro studies in rat hepatocytes and human erythrocytes. Hepatology 14 : 920-926, 1991.
18. Crosignani A, Podda M, Battezzati PM et al : Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration. Hepatology 14 : 1000-1007, 1991.