Another view of the selective model of thymocyte selection

Cell

Volumn 73, Issue 2, 1993, Pages 225-236

  Chan, Susan H ^a,b   Cosgrove, Dominic ^a,b   Waltzinger, Caroline ^a,b   Benoist, Christophe ^a,b   Mathis, Diane ^a,b  

^a CNRS   (France)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CALCIUM IONOPHORE; CD4 ANTIGEN; CD69 ANTIGEN; CD8 ANTIGEN; COMPLEMENTARY DNA; LYMPHOCYTE SURFACE MARKER; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; PHORBOL 13 ACETATE 12 MYRISTATE; T LYMPHOCYTE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ANTIGEN SPECIFICITY; ARTICLE; BIOLOGICAL MODEL; COMBINED IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOFLUOROMETRY; DOWN REGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTE SUBPOPULATION; MAJOR HISTOCOMPATIBILITY COMPLEX RESTRICTION; MOUSE; NONHUMAN; ONTOGENY; PRIORITY JOURNAL; THYMOCYTE; TRANSGENIC MOUSE;

ANIMAL; ANTIGENS, CD8; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BASE SEQUENCE; BROMODEOXYURIDINE; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL DIVISION; DNA; DNA NUCLEOTIDYLEXOTRANSFERASE; FLOW CYTOMETRY; HISTOCOMPATIBILITY ANTIGENS CLASS I; HISTOCOMPATIBILITY ANTIGENS CLASS II; IONOMYCIN; MICE; MICE, MUTANT STRAINS; MOLECULAR SEQUENCE DATA; OLIGODEOXYRIBONUCLEOTIDES; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SUPPORT, NON-U.S. GOV'T; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, HELPER-INDUCER; TETRADECANOYLPHORBOL ACETATE; THYMUS GLAND;

ANIMALIA; MUS MUSCULUS;

EID: 0027153897     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90225-F     Document Type: Article

References (52)

1. Activation events during thymic selection
2. Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand
3. Regulation of N region diversity in antigen receptors through thymocyte differentiation and thymus ontogeny
4. Development of the CD4 and CD8 lineage of T cells: instruction versus selection
5. Exclusion and inclusion of α and β T cell receptor alleles
6. Towards an integrated view of thyomopoiesis
7. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors
8. Mitogen-induced II-2 production and proliferation at defined stages of T helper differentiation
9. Mice lacking MHC class II molecules
10. − thymocytes represents an intermediate stage in intrathymic repertoire selection
11. Kinetics of mature T-cell development in the thymus
12. Molecular and cellular events of T cell development
13. Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells
14. + precursors
15. T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages
16. The antigen-specific major histocompatibility complex-restricted receptor on T cells
17. lck with CD4 inhibits the induction of growth through the αβ T cell receptor
18. + T cell subsets defined
19. + T-cell subsets
20. Kinetics and efficacy of positive selection in the thymus of normal and T cell receptor transgenic mice
21. Accessories or coreceptors?
22. + T cells in transgenic mice expressing a class II MHC-restricted antigen receptor
23. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules
24. + T cells
25. Characterization of a monoclonal antibody which detects all murine αβ T cell receptors
26. Taking the thymus to pieces
27. L3T4+ cytotoxic T lymphocytes specific for class I H-2 antigens are activated in primary mixed lymphocyte reactions
28. d class I MHC determinants directly
29. Phenotypic and functional stages in the intrathymic development of αβ T cells
30. Functional and phenotypic delineation of two subsets of CD4 single positive cells in the thymus
31. Distinct sequence of negative or positive selection implied by thymocyte T-cell receptor densities
32. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen
33. − thymocytes are functionally immature
34. Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage
35. The generation of mature T cells requires interaction of the αβ T-cell receptor with major histocompatibility antigens
36. Signal for T-cell differentiation to a CD4 cell lineage is delivered by CD4 transmembrane region and/or cytoplasmic tail
37. Selective expression of an antigen receptor on CD8-bearing T lymphocytes in transgenic mice
38. Positive and negative selection of an antigen receptor on T cells in transgenic mice
39. Disorganization and restoration of thymic medullary epithelial cells in T cell receptornegative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment
40. 2+ thymocytes as post-selection intermediates leading to mature T cells
41. bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship
42. Growth of epithelial cells in the thymic medulla is under the control of mature T cells
43. + thymocytes
44. + thymocytes
45. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells
46. Participation of CD4 coreceptor molecules in T-cell repertoire selection
47. Thymocyte expression of RAG-1 and RAG-2: termination by T cell receptor cross-linking
48. lck
49. Qa-2 expression in the adult murine thymus: a unique marker for a mature thymic subset
50. The selection of the heterodimeric T-cell receptor for antigen
51. − thymocytes lacking the heat-stable antigen
52. + cytolytic T cells