Transport of celiprolol across human intestinal epithelial (Caco‐2) cells: mediation of secretion by multiple transporters including P‐glycoprotein

British Journal of Pharmacology

Volumn 110, Issue 3, 1993, Pages 1009-1016

  Karlsson, Johan ^a   Kuo, Shiu‐Ming ^b   Ziemniak, John ^b   Artursson, Per ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b SANOFI   (France)

Author keywords

Caco 2; Celiprolol; drug absorption; epithelial cell culture; epithelial transport; intestinal epithelium; intestinal secretion; intestinal transport; organic cation proton exchanger; P glycoprotein

Indexed keywords

ACEBUTOLOL; ACETAZOLAMIDE; AMILORIDE; ATENOLOL; BAMBUTEROL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CEFALEXIN; CELIPROLOL; CHLORTALIDONE; CHOLINE; CIMETIDINE; GLYCOPROTEIN P; HYDROCHLOROTHIAZIDE; INDOMETACIN; MANNITOL; METOPROLOL; N METHYLNICOTINAMIDE; NIFEDIPINE; OUABAIN; PAFENOLOL; PROPRANOLOL; RADIOISOTOPE; TERBUTALINE; TETRYLAMMONIUM; VERAPAMIL; VINBLASTINE;

ARTICLE; CELL CULTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; HUMAN; HUMAN CELL; INTESTINE ABSORPTION; INTESTINE EPITHELIUM CELL; ION EXCHANGE; PH; PRIORITY JOURNAL;

ADRENERGIC BETA-AGONISTS; ADRENERGIC BETA-ANTAGONISTS; BIOLOGICAL AVAILABILITY; BIOLOGICAL TRANSPORT; BUFFERS; CARRIER PROTEINS; CELIPROLOL; CELL LINE; CHOLINE; DOSE-RESPONSE RELATIONSHIP, DRUG; EPITHELIAL CELLS; EPITHELIUM; HUMAN; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; INTESTINES; KINETICS; MEMBRANE GLYCOPROTEINS; P-GLYCOPROTEIN; SUPPORT, NON-U.S. GOV'T; TRITIUM; VINBLASTINE;

EID: 0027146389     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1993.tb13914.x     Document Type: Article

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