Inhibitors of Cholesterol Biosynthesis. 1. 3,5-Dihydroxy-7-(N-imidazolyl)-6-heptenoates and -heptanoates, a Novel Series of HMG-CoA Reductase Inhibitors

Journal of Medicinal Chemistry

Volumn 36, Issue 23, 1993, Pages 3646-3657

  Chan, Chuen ^a,b   Bailey, Esme J ^a,b   Hartley, C David ^a,b   Hayman, David F ^a,b   Hutson, Julie L ^a,b   Inglis, Graham G A ^a,b   Jones, Paul S ^a,b   Keeling, Suzanne E ^a,b   Kirk, Barrie E ^a,b   Lamont, R Brian ^a,c   Lester, Michael G ^a,b   Pritchard, John M ^a,b   Ross, Barry C ^a,b   Scicinski, Jan J ^a,b   Spooner, Stephen J ^a,b   Smith, Geoffrey ^a,b   Steeples, Ian P ^a,b   Watson, Nigel S ^a,b  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Department of Medicinal Chemistry ^*  (United Kingdom)

^c Hexagon House   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3,5 DIHYDROXY 7 (1 IMIDAZOLYL) 6 HEPTENOIC ACID; 3,5 DIHYDROXY 7 (1 IMIDAZOLYL)HEPTANOIC ACID; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; SIMVASTATIN; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CHEMICAL BOND; CHOLESTEROL SYNTHESIS; DRUG SYNTHESIS; ENANTIOMER; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIPOPHILICITY; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMAL; CHOLESTEROL; COMPARATIVE STUDY; CRYSTALLOGRAPHY, X-RAY; HEPTANOATES; HYDROXY ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMIDAZOLES; LOVASTATIN; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PRAVASTATIN; RATS;

EID: 0027145575     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00075a020     Document Type: Article

References (43)

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