Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080

British Journal of Pharmacology

Volumn 110, Issue 3, 1993, Pages 1017-1022

  Brown, Colin A ^a   Chan, Susan L F ^a   Stillings, Michael R ^b   Smith, Stephen A ^c   Morgan, Noel G ^a  

^a KEELE UNIVERSITY   (United Kingdom)

^b Reckitt & Colman   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

adrenoceptor; efaroxan; glibenclamide; imidazoline receptors; insulin secretion; Islets of Langerhans; potassium channel; RX801080; sulphonylurea; 2 antagonist

Indexed keywords

2 (2,3 DIHYDRO 2 BENZOFURANYL) 2 IMIDAZOLINE; 2 (2,3 DIHYDRO 2 PENTYLBENZOFURAN 2 YL) 2 IMIDAZOLINE; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; DIAZOXIDE; EFAROXAN; GLIBENCLAMIDE; GLUCOSE; IMIDAZOLINE DERIVATIVE; IMIDAZOLINE RECEPTOR; INSULIN; MIDAGLIZOLE; PHENTOLAMINE; POTASSIUM CHANNEL; RADIOISOTOPE; SULFONYLUREA DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; INSULIN RELEASE; LIGAND BINDING; MALE; NONHUMAN; PANCREAS ISLET; PRIORITY JOURNAL; RAT;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; BENZOFURANS; BINDING, COMPETITIVE; CELL MEMBRANE; DRUG INTERACTIONS; GLYBURIDE; IMIDAZOLES; INSULIN; ISLETS OF LANGERHANS; KINETICS; MALE; RATS; RATS, WISTAR; RECEPTORS, DRUG; STIMULATION, CHEMICAL; SUPPORT, NON-U.S. GOV'T;

EID: 0027144034     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1993.tb13915.x     Document Type: Article

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