A Correlation Between the Permeability Characteristics of a Series of Peptides Using an in Vitro Cell Culture Model (Caco-2) and Those Using an in Situ Perfused Rat Ileum Model of the Intestinal Mucosa

Pharmaceutical Research: An Official Journal of the American Association of Pharmaceutical Scientists

Volumn 10, Issue 12, 1993, Pages 1710-1714

  Kirn, Dong Chool ^a   Burton, Philip S ^b   Borchardt, Ronald T ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b PFIZER INC   (United States)

Author keywords

Caco 2; in situ perfusion; in vitro cell culture; intestinal mucosa; peptides; permeability; rat ileum

Indexed keywords

PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; ILEUM; INTESTINE MUCOSA; LIPOPHILICITY; NONHUMAN; PARTITION COEFFICIENT; PERMEABILITY; PRIORITY JOURNAL; RAT;

AMINO ACID SEQUENCE; ANIMAL; CELLS, CULTURED; CHEMISTRY, PHYSICAL; ILEUM; IN VITRO; INTESTINAL ABSORPTION; INTESTINAL MUCOSA; MALE; MESENTERIC VEINS; MOLECULAR SEQUENCE DATA; PEPTIDES; PERMEABILITY; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, NON-U.S. GOV'T;

EID: 0027141263     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1023/A:1018961828510     Document Type: Article

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