The antiinflammatory mechanism of methotrexate: Increased adenosine release at inflamed sites diminishes leukocyte accumulation in an in vivo model of inflammation

Journal of Clinical Investigation

Volumn 92, Issue 6, 1993, Pages 2675-2682

  Cronstein, Bruce N ^a   Naime, Dwight ^a   Ostad, Edward ^a  

^a NEW YORK UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Adenosine; Inflammation; Leukocyte; Methotrexate; Purine

Indexed keywords

3,7 DIMETHYL 1 PROPARGYLXANTHINE; 5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ADENOSINE; ADENOSINE DEAMINASE; DEXAMETHASONE; METHOTREXATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; INFLAMMATION; INTRAPERITONEAL DRUG ADMINISTRATION; LEUKOCYTE FUNCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ADENOSINE DEAMINASE; AMINOIMIDAZOLE CARBOXAMIDE; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CARRAGEENAN; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMATION; KINETICS; LEUKOCYTES; METHOTREXATE; MICE; MICE, INBRED BALB C; RECEPTORS, PURINERGIC P1; RIBONUCLEOTIDES; SPLEEN; SUPPORT, U.S. GOV'T, P.H.S.; THEOBROMINE; TIME FACTORS;

EID: 0027139914     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116884     Document Type: Article

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