Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis: Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones

Journal of Clinical Investigation

Volumn 92, Issue 6, 1993, Pages 2633-2643

  Meinl, Edgar ^a   Weber, Frank ^a   Drexler, Klaus ^a,d   Morelle, Christèle ^c   Ott, Michael ^c   Saruhan Direskeneli, Güher ^a,e   Goebels, Norbert ^a   Ertl, Birgit ^a   Jechart, Gertrud ^a   Giegerich, Gerhard ^a,f   Schönbeck, Simone ^a,b   Bannwarth, Willi ^c   Wekerle, Hartmut ^a   Hohlfeld, Reinhard ^a,b  

^a MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c F HOFFMANN LA ROCHE LTD   (Switzerland)

^d Baxter Deutschland GmbH   (Germany)

^e ISTANBUL UNIVERSITY   (Turkey)

^f UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Autoimmunity; HLA DR antigen; Immunodominant epitopes; MHC class II genes; T cell receptors

Indexed keywords

EPITOPE; MYELIN BASIC PROTEIN; T LYMPHOCYTE RECEPTOR;

AMINO ACID SEQUENCE; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; ARTICLE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LYMPHOCYTE CLONE; MALE; MULTIPLE SCLEROSIS; PATHOGENESIS; PRIORITY JOURNAL;

ADULT; AMINO ACID SEQUENCE; BASE SEQUENCE; BRAIN CHEMISTRY; DNA; DNA PRIMERS; EPITOPES; FEMALE; HLA ANTIGENS; HLA-D ANTIGENS; HUMAN; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGE; MOLECULAR SEQUENCE DATA; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEINS; POLYMERASE CHAIN REACTION; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; REFERENCE VALUES; T-LYMPHOCYTES; THYMIDINE;

EID: 0027138878     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116879     Document Type: Article

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