Molecular analysis in chronic granulocytic leukaemia: location of breakpoints within M‐BCR and relationship with presentation platelet counts

Clinical & Laboratory Haematology

Volumn 15, Issue 4, 1993, Pages 253-258

  ARDERN, J C ^a   SPEAK, J ^a   HYDE, K ^a   HUNT, L P ^b   LAWSON, R ^c   GORST, D W ^d   GEARY, C G ^a   LUCAS, G S ^a  

^a University Department of Clinical and Laboratory Haematology ^*

^b MANCHESTER ROYAL INFIRMARY   (United Kingdom)

^c UNIVERSITY OF SALFORD   (United Kingdom)

^d ROYAL LANCASTER INFIRMARY   (United Kingdom)

Author keywords

CGL; major breakpoint cluster region (M BCR); Southern blot analysis

Indexed keywords

ADULT; AGED; ARTICLE; CHROMOSOME BREAKAGE; CHRONIC GRANULOCYTIC LEUKEMIA; FEMALE; GENE REARRANGEMENT; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; SOUTHERN BLOTTING;

EID: 0027138112     PISSN: 01419854     EISSN: 13652257     Source Type: Journal    
DOI: 10.1111/j.1365-2257.1993.tb00146.x     Document Type: Article

References (17)

1. Does the site of the breakpoint on chromosome 22 influence the duration of the chronic phase in chronic myeloid leukemia
2. Chronic myelogenous leukaemia‐the unfolding saga
3. Fine mapping of chromosome 22 breakpoints with the breakpoint cluster region (ber) implies a role for ber exon 3 in determining disease duration in chronic myeloid leukemia
4. The relationship between the site of breakpoints within the ber gene and thrombopoiesis of philadelphia‐positive chronic myelocytic leukemia.
5. The position of the M‐BCR breakpoint does not predict the duration of chronic phase or survival in chronic myeloid leukaemia
6. The site of breakpoint within the ber is a prognostic factor in Philadelphia‐positive CML patients
7. Does the breakpoint within the major breakpoint cluster region (M‐ber) influence the duration of the chronic phase in chronic myeloid leukemia? An analytical comparison of current literature
8. Relationship of ber breakpoint to chronic phase duration, survival and blast crisis lineage in chronic myelogenous leukemia patients presenting in early chronic phase
9. A minute chromosome in human chronic granulocytic leukemia
10. 1‐positive CML patients
11. Breakpoint zone of ber in chronic myelogenous leukemia does not correlate with disease phase or prognosis
12. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and geimsa staining
13. CML patients in blast crisis have breakpoints localized to a specific region of the BCR
14. Molecular breakpoints and platelet counts in chronic myeloid leukemia
15. Analysis of breakpoints within the ber gene and their correlation with the clinical course of philadelphia‐positive chronic myelogenous leukemia.
16. Prognosis in chronic myeloid leukaemia: biology of the disease vs. treatment