Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 24, 1993, Pages 11825-11829

  Johansson, I ^a   Lundqvist, E ^a   Bertilsson, L ^a   Dahl, M L ^a   Sjoqvist, F ^a   Ingelman Sundberg, M ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

bufuralol; drug therapy; gene amplification; pharmacogenetics; sparteine

Indexed keywords

CYTOCHROME P450; DEBRISOQUINE;

ADULT; AMINO ACID SUBSTITUTION; ARTICLE; CHILD; DRUG METABOLISM; FEMALE; GENE AMPLIFICATION; GENE LOCUS; GENOTYPE; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INHERITANCE; MALE; OPEN READING FRAME; PHARMACOGENETICS; PRIORITY JOURNAL; PULSED FIELD GEL ELECTROPHORESIS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ALLELES; AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; CASE REPORT; CAUCASOID RACE; CYTOCHROME P-450 CYP2D6; CYTOCHROME P-450 ENZYME SYSTEM; DEBRISOQUIN; DNA PRIMERS; EXONS; FEMALE; GENE AMPLIFICATION; GENOTYPE; HOMINIDAE; HUMAN; KINETICS; MALE; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; POINT MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RESTRICTION MAPPING; SUPPORT, NON-U.S. GOV'T; VARIATION (GENETICS);

EID: 0027136288     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.24.11825     Document Type: Article

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