Ability of the non‐phorbol ester‐type tumor‐promoter thapsigargin to mimic the stimulatory effects of 12‐0‐tetradecanoylphorbol‐13‐acetate on ornithine decarboxylase activity, hydroperoxide production, and macromolecule synthesis in mouse epidermis In vivo

International Journal of Cancer

Volumn 55, Issue 6, 1993, Pages 1036-1043

  Perchellet, Elisabeth M ^a   Gali, Hala U ^a   Gao, Xiao Mei ^a   Perchellet, Jean‐Pierre ^a  

^a KANSAS STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIMYCIN; CYCLOPIAZONIC ACID; ENDOGENOUS COMPOUND; HYDROPEROXIDE; ORNITHINE DECARBOXYLASE; PHORBOL ESTER; THAPSIGARGIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EPIDERMIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SKIN CARCINOGENESIS; TUMOR PROMOTION;

ANIMAL; CARCINOGENS; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; FEMALE; HYDROGEN PEROXIDE; MICE; ORNITHINE DECARBOXYLASE; PROTEIN KINASE C; SKIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TERPENES; TETRADECANOYLPHORBOL ACETATE; THAPSIGARGIN; XANTHINE OXIDASE;

EID: 0027135597     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.2910550626     Document Type: Article

References (41)

1. Effects of phorbol and four diesters of phorbol on the incorporation of tritiated precursors into DNA, RNA and protein in mouse epidermis
2. Characterization of the induction of ornithine decarboxylase activity by benzoyl peroxide in SENCAR mouse epidermis
3. Response modification creates promotability in multistage carcinogenesis
4. Inflammation and oxidative stress in carcinogenesis
5. 2+ stores and activates an influx pathway for divalent cations in HL‐60 cells
6. Suppression of tumor‐promoter‐induced chemiluminescence in mouse epidermal cells by several inhibitors of arachidonic acid metabolism
7. Phorbol ester induction of 8‐lipoxygenase in inbred SENCAR (SSIN) but not C57BL/6J mice correlated with hyperplasia, edema and oxidant generation but not ornithine decarboxylase induction
8. Events associated with mouse skin‐tumor promotion with respect to arachidonic acid metabolism: a comparison between SENCAR and NMRI mice
9. Correlation of phorbol ester promotion in the resistant C57BL/6J mouse with sustained hyperplasia but not ornithine decarboxylase or protein kinase C
10. Hydrogen peroxide formation by cells treated with a tumor promoter
11. Persistent intracellular calcium‐pool depletion by thapsigargin and its influence on cell growth
12. 2
13. Generation of the arachidonic acid metabolite 8‐HETE by extracts of mouse skin treated with phorbol ester in vivo: identification by 1H‐n. m. r. and GC‐MS spectroscopy
14. Thapsigargin, a histamine secretagogue, is a non‐12‐0‐tetradecanoylphorbol‐13‐acetate(TPA)‐type tumor promoter in 2‐stage mouse skin carcinogenesis
15. Enhanced papilloma formation in response to skin‐tumor promotion in transgenic mice over‐expressing the human ornithine decarboxylase gene
16. 2 in the activation of the NADPH oxidase
17. Stimulation of superoxide anion formation by the non‐TPA‐type tumor promoters palytoxin and thapsigargin in porcine and human neutrophils
18. Alterations in epidermal polyamine levels and DNA synthesis following topical treatment with chrysarobin in SENCAR mice
19. Stimulatory effect of thapsigargin, a non‐TPA‐type tumor promoter, on arachidonic acid metabolism in the murine keratinocyte line HEL30 and on epidermal‐cell proliferation in vivo as compared to the effects of phorbol ester TPA
20. Charge‐dependent regulation of NADPH oxidase activities in intact and subcellular systems of polymorphonuclear leukocytes
21. Presence of a functionally altered ornithine decarboxylase activity in chrysarobin‐promoted mouse epidermal papillomas
22. Stimulation of arachidonic acid metabolism in rat peritoneal macrophage by thapsigargin, a non‐12‐0‐tetradecanoylphorbol‐13‐acetate (TPA)‐type tumor promoter
23. Evidence of protein‐kinase‐C involvement in phorbol‐diester‐stimulated arachidonic acid release and prostaglandin synthesis
24. Murine epidermal xanthine oxidase activity: correlation with degree of hyperplasia induced by tumor promoters
25. Stimulation of hydroperoxide generation in mouse skins treated with tumor‐promoting or carcinogenic agents in vivo and in vitro
26. 2+ ionophores A23187 and ionomycin to mimic some of the effects of the tumor promoter 12‐0‐tetradecanoylphorbol‐13‐acetate on hydroperoxide production, ornithine decarboxylase activity and DNA synthesis in mouse epidermis in vivo
27. Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo
28. Antioxidants and multistage carcinogenesis in mouse skin
29. Biochemical markers of skin tumor promotion by thapsigargin
30. Assessment of the antioxidant/pro‐oxidant status of murine skin following topical treatment with 12‐0‐tetradecanoylphorbol‐13‐acetate and throughout the ontogeny of skin cancer. Part I: quantitation of superoxide dismutase, catalase, glutathione peroxidase and xanthine oxidase
31. Production of hydrogen peroxide by murine epidermal keratinocytes following treatment with the tumor promoter 12‐0‐tetradecanoylphorbol‐13‐acetate
32. 2+ transport ATPases by thapsigargin
33. Inhibition of protein kinase C by ether‐linked lipids is not correlated with their anti‐neoplastic activity on WEHI‐3B and R6X‐B15 cells
34. Enhanced hydroperoxide production by peripheral‐blood leukocytes following exposure of murine epidermis to 12‐0‐tetradecanoylphorbol‐13‐acetate
35. Multistage skin‐tumor promotion and specificity of inhibition
36. Prostratin, a non‐promoting phorbol ester, inhibits induction by phorbol 12‐myristate 13‐acetate of ornithine decarboxylase, edema and hyperplasia in CD‐1 mouse skin
37. 2+‐ATPase
38. The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase
39. in vivo formation of oxidized DNA bases in tumor‐promoter‐treated mouse skin
40. Induction of superoxide by 12‐0‐tetradecanoylphorbol‐13‐acetate and thapsigargin, a non‐phorbol‐ester‐type tumor promoter, in peritoneal macrophages elicited from SENCAR and B6C3F1 mice: a permissive role for the arachidonic acid cascade in signal transduction
41. Reversibility of the ionomycin‐promoted synaptosomal hydrogen peroxide production