NMR Structural Studies of the Tight Complex between a Trifluoromethyl Ketone Inhibitor and the 85-kDa Human Phospholipase A2

Biochemistry

Volumn 32, Issue 47, 1993, Pages 12560-12565

  Trimble, Laird A ^a   Street, Ian P ^a   Perrier, Hélène ^a   Tremblay, Nathalie M ^a   Weech, Philip K ^a   Bernstein, Michael A ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONYL TRIFLUOROMETHYL KETONE; CALCIUM ION; CHYMOTRYPSIN A; PHOSPHOLIPASE A2; PHOSPHOLIPASE INHIBITOR; UNCLASSIFIED DRUG;

ACYLATION; AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; COVALENT BOND; CYTOSOL; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ENZYME STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; STOICHIOMETRY;

ARACHIDONIC ACIDS; CARBON; CHYMOTRYPSIN; COMPARATIVE STUDY; DEUTERIUM; FLUORINE; HUMAN; ISOTOPES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; PHOSPHOLIPASES A;

EID: 0027131849     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00210a002     Document Type: Article

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