Nonpeptide Angiotensin II Antagonists Derived from 1H-Pyrazole-5-carboxylates and 4-Aryl-1H-imidazole-5-carboxylates

Journal of Medicinal Chemistry

Volumn 36, Issue 23, 1993, Pages 3595-3605

  Ashton, Wallace T ^a   Hutchins, Steven M ^a   Greenlee, William J ^a   Doss, George A ^a   Chang, Raymond S L ^b   Lotti, Victor J ^b   Faust, Kristie A ^b   Chen, Tsing Bau ^b   Zingaro, Gloria J ^b   Kivlighn, Salah D ^b   Siegl, Peter K S ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 3 BUTYL 4 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1H PYRAZOLE 5 CARBOXYLIC ACID; 2 BUTYL 4 (2 CHLOROPHENYL) 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1H IMIDAZOLE 5 CARBOXYLIC ACID; 3 BUTYL 1 (2,6 DICHLOROPHENYL) 4 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1H PYRAZOLE 5 CARBOXYLIC ACID; 3 BUTYL 4 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1 [2 (TRIFLUOROMETHYL)PHENYL] 1H PYRAZOLE 5 CARBOXYLIC ACID; 3 PROPYL 4 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1 (2,2,2 TRIFLUOROETHYL) 1H PYRAZOLE 5 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN RECEPTOR; CARBOXYLIC ACID DERIVATIVE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONGESTIVE HEART FAILURE; DRUG POTENCY; HYPERTENSION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; ORAL DRUG ADMINISTRATION; RABBIT; RAT;

ANGIOTENSIN II; ANIMAL; AORTA; BLOOD PRESSURE; CARBOXYLIC ACIDS; CHEMISTRY, PHYSICAL; IMIDAZOLES; MALE; MOLECULAR STRUCTURE; PYRAZOLES; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027131808     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00075a014     Document Type: Article

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