p53 codon 249ser mutations in hepatocellular carcinoma patients with low aflatoxin exposure

The Lancet

Volumn 339, Issue 8797, 1992, Pages 881-

  Patel, Pragna ^a   Stephenson, Janet ^a   Scheuer, PeterJ ^a   Francis, GillianE ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN;

ADULT; CONTROLLED STUDY; ENVIRONMENTAL FACTOR; FEMALE; HUMAN; LETTER; LIVER CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; MUTATION; PRIORITY JOURNAL; CODON; ENVIRONMENTAL EXPOSURE; GENETICS; LIVER TUMOR; TUMOR SUPPRESSOR GENE;

AFLATOXINS; CARCINOMA, HEPATOCELLULAR; CODON; ENVIRONMENTAL EXPOSURE; GENES, P53; HUMAN; LIVER NEOPLASMS; MUTATION;

EID: 0027111365     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(92)90332-W     Document Type: Letter

References (8)

1. p53 mutation in hepatocellular carcinoma after aflatoxin exposure
2. Hepatocellular carcinoma mutation
3. Mutational hotspot in the p53 gene in human hepatocellular carcinomas
4. Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa
5. Carcinogens leave fingerprints
6. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G-T and A-C substitutions
7. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus-positive hepatocellular carcinomas
8. Tissue extraction of DNA and RNA and analysis by the polymerase chain reaction