Mechanisms of chemoprotection by oltipraz

Journal of Cellular Biochemistry

Volumn 50, Issue S16I, 1992, Pages 167-172

  Kensier, Thomas ^a   Stcyzynski, Peter ^a   Groopman, John ^a   Helzlsouer, Kathy ^a   Curphey, Thomas ^b   Maxcultenko, Yulla ^b   Roebuck, B D ^b  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

1,2 dithiole 3 thiones; antischistosomiasis; carcinogen detoxication; DNA adducts; enzyme induction; glutathione; Oltipraz; S transferases

Indexed keywords

CARCINOGEN; OLTIPRAZ; ANTINEOPLASTIC AGENT; PYRAZINE DERIVATIVE;

CANCER; CHEMOPROPHYLAXIS; CLINICAL TRIAL; CONFERENCE PAPER; HUMAN; NONHUMAN; PRIORITY JOURNAL; RODENT; ANIMAL; DISEASE MODEL; REVIEW;

ANIMAL; ANTICARCINOGENIC AGENTS; DISEASE MODELS, ANIMAL; HUMAN; PYRAZINES;

EID: 0027105175     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.240501331     Document Type: Article

References (35)

1. The chemistry of the 1,2‐dithiole ring
2. 1,2‐Dithiol‐3‐thione and dithioester analogues: Potential radioprotectors
3. Chemoprotection by oltipraz and other dithiolethiones
4. The chemotherapy of schistosomiasis
5. The antischistosomal activity of oltipraz
6. Biochemical effects of dithiolthiones
7. On the mechanism of induction of cancer protective enzymes: A unifying proposal
8. Phase I study of 4‐methyl‐5‐(2‐pyrazinyl)‐1,2‐dithiole‐3‐thiol [oltipraz: RP 35972] in male patients with previously resected colon polyps and first degree relatives of breat cancer patients
9. Chemoprotective effects of two dithilthiones and of butylhydroxyanisole against carbon tetrachloride and acetaminophen toxicity
10. Role of glutathione in oltipraz‐induced protection in acetaminophen or allyl alcohol hepatotoxicity in the male hamster
11. Oltipraz induced amelioration of acetaminophen hepatotoxicity in hamsters
12. 1 in the rat
13. Inhibitory effects of 5‐(2‐pyrazinyl)‐4‐methyl‐1,2‐ dithiol‐3‐thione (oltipraz) on carcinogenesis inducec by benze[α]pyrene, diethylnitrosamine an duracil mustard
14. Identification of candidate cancer chemopreventive agents and their evaluation in animal models and human clinicla trials: A review
15. Efficacy of cancer chemopreventive agents in different animal of cancer chemopreventive agents in different animal organ systems
16. Ihibition by dietary oltipraz of experimental intestinal carcinogenesis induced by azoxymethane in male F344 rats
17. 1‐induced hepato‐carcinogenesis in F344 rats by 5‐(2‐pyrazinyl)‐4‐methyl‐1,2‐dithoiole‐3‐thione (oltipraz): Predictive role for short‐term molecular dosimetry
18. Chemoprevention of mouse skin tumorigenesis by dietary oltipraz
19. Mechanism of protection against aflatoxin tumorigenicity in rats fed 5‐(2‐pyraziny1)‐4‐methy1‐1,2‐dithiol‐3‐thione (oltipraz) and related 1,2‐dithiol‐3‐thione and 1,2‐dithio1‐3‐ones
20. Effects of sulindac and oltipraz on the tumorigenicity of 4‐(methylnitrosamino)1‐(3‐pyridy1)‐1‐butanone in A/J mouse lung
21. Combination chemoprevention of expreimental bladder cancer
22. Retinoid chmoprevention of lung cancer
23. 1 binding to DNA in vivo in rats fed phenolic antioxidants, ethoxyquin and a dithiolthione
24. Chemoprotection against aflatoxin‐induced hepatocarcinogenesis by dithiolethiones
25. 1 by glutathione and glutathione transferases in vitro
26. Transcriptional control of glutathione S‐transferase gene expression by the chemoprotective agent 5‐(2‐pyrazing1)‐4‐methy1‐1,2‐dithiole‐3‐thione (oltipraz) in rat liver
27. Regulation of glutathione S‐transferase Ya subunit gene expression: Identification of a unique xenobiotic‐responsive element controlling inducible expression by planar aromatic compounds
28. 1 metabolism
29. 7‐guanine formation, and hepatic tumorigenesis in rats fed ethoxyquin: Role of induction of glutathione S‐transferases
30. Cell proliferation in carcinogenesis
31. Epidemiology of bladder cancer
32. The causes of cancer
33. Changing cigarette habits and bladder cancer risk: A case control study
34. Cancer of the bladder
35. Chemoprevention of bladder cancer