Detection of mutations in the p53 gene in human head and neck carinomas by single strand conformation polymorphism analysis

Cancer Letters

Volumn 67, Issue 2-3, 1992, Pages 167-174

  Chang, Yu Sun ^a   Lin, Yu Jung ^a   Tsai, Chi Neu ^a   Shu, Chih Hung ^b   Tsai, Min Shiu ^c   Choo, Kong Bung ^b   Liu, Shih Tung ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Epstein Barr virus; head and neck tumors; human papillomavirus; nasopharyngeal carcinoma; p53 gene mutations

Indexed keywords

PROTEIN P53;

ARTICLE; CONTROLLED STUDY; DELETION MUTANT; EPSTEIN BARR VIRUS; EXON; GENE MUTATION; HEAD TUMOR; HUMAN; HUMAN TISSUE; NASOPHARYNX CARCINOMA; NECK TUMOR; POINT MUTATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SINGLE STRAND CONFORMATION POLYMORPHISM; TUMOR BIOPSY; WART VIRUS;

BASE SEQUENCE; CARCINOMA; DNA, NEOPLASM; GENES, P53; HEAD AND NECK NEOPLASMS; HERPESVIRUS 4, HUMAN; HUMAN; MOLECULAR SEQUENCE DATA; MUTATION; NASOPHARYNGEAL NEOPLASMS; PAPILLOMAVIRUS; POLYMERASE CHAIN REACTION; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED; TUMOR VIRUS INFECTIONS;

HUMAN HERPESVIRUS 4; HUMAN PAPILLOMAVIRUS; HUMAN PAPILLOMAVIRUS TYPES;

EID: 0027099684     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(92)90140-Q     Document Type: Article

References (30)

1. Aberrant expression of the p53 oncoprotein is a common feature of a wild spectrum of human malignancies
2. Archival analysis of p53 genetic and protein alterations in Chinese esopharyngeal cancer
3. Detection of Epstein-Barr virus DNA sequences in nasopharyngeal carcinoma cells by enzymatic DNA amplification
4. Characterization of two newly established EBV-containing lymphoblastoid cell lines from patients with myeloid leukemias
5. Participation of p53 cellular tumor antigen in transformation of normal embronic cells
6. p53 is frequently mutated in Burkitt's lymphoma cell lines
7. Elevated p53 expression correlates with a history of heavy smoking in squamous cell carcinoma of the head and neck
8. The p53 protooncogene can act as a suppressor of transformation
9. p53 mutations in human lymphoid malignancies: association with Burkitt's lymphoma and chronic lymphocytic leukemia
10. Chemical and physical carcinogenesis advances and perspectives for the 1990s
11. Use of the single strand conformation polymorphism technique and PCR to detect p53 gene mutations in small cell lung cancer
12. Loss of heterozygosity on the short arm of chromosome 3 in nasopharyngeal carcinoma
13. Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53
14. T-antigen is bound to a host protein in SV40 transformed cells
15. The p53 tumor suppressor gene
16. Characterization of a 54K dalton cellular SV40 tumor antigen present in SV40 transfonned cells and uninfected embryonal carcinoma
17. 6-methylguanine built into a unique site in a viral genome
18. Detection of p53 gene mutations in human brain tumors by single-strand conformation polymorphism analysis of polymerase chain reaction products
19. Mutations in the p53 gene occur in diverse human tumor types
20. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction
21. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene
22. p53 mutations in colorectal cancer
23. DNA sequencing with chain terminating inhibitors
24. Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells
25. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
26. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines
27. Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene
28. Identification of intronic point mutations as an alternative mechanism for p53 inactivation in lung cancer
29. Association of human papillomavirus types 16 and 18 E6 proteins with p53
30. Direct mutagenesis of Ha-ras-1 oncogenes by N-nitroso-N-methylurea during initiation of mammary carcinogenesis in rats