Camptothecin inhibits both the cleavage and religation reactions of eukaryotic DNA topoisomerase I

Journal of Molecular Biology

Volumn 228, Issue 4, 1992, Pages 1025-1030

  Kjeldsen, Eigil ^a   Svejstrup, Jesper Q ^a   Gromova, Irina I ^a   Alsner, Jan ^a   Westergaard, Ole ^a  

^a AARHUS UNIVERSITY   (Denmark)

Author keywords

camptothecin; cleavage; religation; suicide DNA; topoisomerase I

Indexed keywords

CAMPTOTHECIN; DNA TOPOISOMERASE; DOUBLE STRANDED DNA;

ARTICLE; DRUG ACTIVITY; ENZYME INHIBITION; EUKARYOTE; PRIORITY JOURNAL;

BASE SEQUENCE; CAMPTOTHECIN; COMPARATIVE STUDY; DNA; DNA TOPOISOMERASES, TYPE I; EUKARYOTIC CELLS; HUMAN; MACROMOLECULAR SYSTEMS; MOLECULAR SEQUENCE DATA; SUPPORT, NON-U.S. GOV'T;

EUKARYOTA;

EID: 0027092752     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/0022-2836(92)90310-G     Document Type: Article

References (23)

1. Strand specificity of the topoisomerase II mediated double-stranded DNA cleavage reaction
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3. A high affinity topoisomerase I binding sequence is clustered at DNAase I hypersensitive sites in tetrahymena r-chromatin
4. Preferential relaxation of supercoiled DNA containing a hexadecameric recognition sequence for topoisomerase I
5. The effects of camptothecin on the reaction and the specificity of the wheat germ type I topoisomerase
6. Mapping of sequence-specific chromatin proteins by a novel method: topoisomerase I on tetrahymena ribosomal chromatin
7. Protein-linked DNA strand breaks induced in mammalian cells by camptothecin, an inhibitor of topoisomerase I
8. Induction of chromosomal aberrations and SCE by camptothecin, an inhibitor of mammalian topoisomerase I
9. DNA topoisomerase I-targeted chemotherapy of human colon cancer in xenografts
10. Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of calf thymus type I topoisomerase
11. On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex
12. Irreversible trapping of the DNA-topoisomerase I covalent complex
13. Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I
14. Effect of local DNA sequence on topoisomerase I cleavage in the presence or absence of camptothecin
15. Camptothecin effects on DNA synthesis in murine leukemia cells
16. Sequence-dependent effect of camptothecin on human topoisomerase I DNA cleavage
17. Characterization of a camptothecin-resistant human DNA topoisomerase I
18. Eukaryotic topoisomerase I-DNA interaction is stabilized by helix curvature
19. DNA topoisomerase-targeting antitumor drugs can be studied in yeast
20. Specificity and flexibility of the recognition of DNA helical structure by eukaryotic topoisomerase I
21. Minimal DNA duplex requirements for topoisomerase I-mediated cleavage in vitro
22. New technique for uncoupling the cleavage and religation reactions of eukaryotic topoisomerase I. The mode of action of camptothecin at a specific recognition site
23. Sequence specificity of DNA topoisomerase I in the presence and absence of camptothecin