Treatment of pain with pancreatic extracts in chronic pancreatitis: Results of a prospective placebo-controlled multicenter trial

Digestion

Volumn 53, Issue 1, 1992, Pages 54-66

  Müssner, Joachim ^a   Secknus, Roger ^a   Meyer, Jürgen ^b   Niederau, Claus ^c   Adlerd, Guido ^d  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF ULM   (Germany)

Author keywords

Chronic pancreatitis; Pain; Pancreatic extracts

Indexed keywords

FECES LIPID; PANCREAS ENZYME; PANCREAS EXTRACT; PANZYTRAT; PROTEINASE; SCOPOLAMINE BUTYL BROMIDE; TRAMADOL;

ARTICLE; BLOOD CHEMISTRY; CHRONIC PANCREATITIS; CLINICAL ARTICLE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; ECHOGRAPHY; ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY; ENZYME REGULATION; ENZYME RELEASE; FECES ANALYSIS; FEMALE; HUMAN; MALE; NEGATIVE FEEDBACK; ORAL DRUG ADMINISTRATION; PAIN ASSESSMENT; PANCREAS DUCT; PHYSICAL EXAMINATION; PRESSURE; PRIORITY JOURNAL; VISCERAL PAIN;

ADULT; ANALGESICS; CHRONIC DISEASE; DOUBLE-BLIND METHOD; FEEDBACK; FEMALE; HUMAN; MALE; MIDDLE AGE; PAIN; PAIN MEASUREMENT; PANCREAS; PANCREATIN; PANCREATITIS; PROSPECTIVE STUDIES; SUPPORT, NON-U.S. GOV'T;

EID: 0027081685     PISSN: 00122823     EISSN: 14219867     Source Type: Journal    
DOI: 10.1159/000200971     Document Type: Article

References (48)

1. Green G.M., Lyman R.L.: Feedback regulation of pancreatic enzyme secretion as a mechanism for trypsin inhibitor-induced hypersecretion in rats. Proc. Soc. exp. Biol. Med. 140.6-12 (1972).
2. Ihse I., Lilja P., Lundquist I.: Trypsin as a regulator of pancreatic secretion in the rat. Scand. J. Gas-troenl. 13:873-880 (1979).
3. Louic D.S., May D., Miller P., Owyang C: Cholecystokinin mediates feedback regulation of pancreatic enzyme secretion in rats. Am. J. Physiol. 250: G252-G259 (1986).
4. Rausch U., Adler G., Weidcnbach H., Weidenbach F., Rudolff D., Koop I., Kern H.F.: Stimulation of pancreatic secretory process in the ralbv low-molecular weight proteinase inhibitor. 1. Dose-response study on enzyme content and secretion. cholecystokinin release and pancreatic fine structure. Cell Tiss. Res. 247. 187-193 (1987).
5. Shiratori K., Chen Y.F., Chey W.Y., Lee K.Y., Chang T.M.: Mechanism of increased exocrine pancreatic secretion in pancreatic juice-diverted rats. Gastroenterology 91:1171-1178 (1986)
6. Chernick S.S., Lepkovsky S., Chaikoff I.L.: A dietary factor regulating the enzyme content of the pancreas: changes induced in size and proteolytic activity of the chick pancreas by ingestion of raw soybean meal. Am. J. Physiol. 155: 33-41 (1948).
7. Corring T.: Mechanisme dc la sd-cretion pancrcaliquc exocrine chez le pore: regulation par retroinhibi-tion. Annls Biol. anim. Biochim. Biophys. 13:755-756 (1973).
8. Lee P.C., Newman B.M., Praiss-man M., Cooncy D.R., Lcbenthal E., Cholecystokinin.: a factor responsible for the enteral feedback control of pancreatic hypertrophy. Pancreas 335-340 (1986).
9. Folsch U.R., Cantor P., Wilms H.M., Schafmayer A., Becker H.D., Crcutzfeldt W.: Role of cholecystokinin in the negative feedback control of pancreatic enzyme secretion in conscious rats. Gastroenterology 92:499-506 (1987).
10. Fukuoka S.-L., Kawajiri H., Fushi-ki T., Takahashi K., Iwai K., Lo-calizalion of pancreatic enzyme se-crelion-slimulaling activity and trypsin inhibitory activity in zymogen granule of the rat pancreas. Biochim. biophys. Acta 84: 18-24 (1986).
11. Lu L., Louie D., Owyang C.: A cholecystokinin releasing peptide mediates feedback regulation of pancreatic secretion. Am. J. Physiol. 256. G430-G435 (1989).
12. Herzig K.H., Tatemoto K., Louie D.S., Owyang C.: Isolation and characterization of a novel peptide from the duodenum that stimulates pancreatic secretion. Digestion 46: suppl. l.p.43 (1990).
13. Ihsc I., Lilja P., Lundquist I.: Feedback regulation of pancreatic enzyme secretion by intestinal trypsin in man. Digestion 18: 303-308 (1977).
14. Liencr I.E., Goodale R.L., Desh-mukh A., Satterberg T.L., Ward G., DiPictro CM., Bankey P.E., Borner J.W., Effect of a trypsin inhibitor from soybeans (Bowman-Birk) on the secretory activity of the human pancreas. Gastroenterology 94:419-427 (1984).
15. Slaff J., Jacobson D., Tillman C.R., Curingion, C., Toskes, P.: Pro-tcase-specific suppression of pancreatic exocrine secretion. Gastroenterology 87:44-52 (1984).
16. Dlugosz, J., Folsch, U.R., Czajkowski, A., Gabryelewicz, A.; Feedback regulation of stimulated pancreatic enzyme secretion during inlraduo-denal perfusion or trypsin in man. Eur. J. din. Invest. 18: 267-272 (1988)
17. Owyang Ci Louie D.S., Tatum D.: Feedback regulation of pancreatic-enzyme secretion. Suppression of cholecystokinin release by trypsin. J. din. Invest. 77:2042-2047 (1986)
18. Owyang C., May D., Louie D.S., Trypsin suppression of pancreatic enzyme secretion. Differential effect of cholecystokinin release and the enteropancrcatic reflex. Gastroenterology 91:637-643 (1986).
19. Adler G., Mullcnhoft, A., Koop, LJ., Bozkurt, T., Goke, B., Beglinger, C, Arnold, R., Stimulation of pancreatic secretion in man by a protease inhibitor. Eur. J. clin. Invest. 18: 98-104 (1988).
20. Adler G., Rcinshagen M., Koop I., Goke B., Schafmaycr A., Rovati L.C., Arnold R.: Differential effects ofatropineandacholecystokinin receptor antagonist on pancreatic secretion. Gastroenterology 96: 1158-1164 (1989).
21. Layer P., Jansen J.B.M.J., Cherian L., Lamers C.B.H.W., Gocbell H.: Feedback regulation of human pancreatic secretion. Effects of protease inhibition on duodenal delivery and small intestinal transit of pancreatic enzymes. Gastroenterology 98: 1311-1319 (1990).
22. Krawisz B.R., Miller L.J., DiMa-gno E.P., Go V.L.W.: In the absence of nutrients, pancreatic-biliary secretions in the jejunum do not exert feedback control of human pancreatic or gastric function. J. Lab. clin. Med. 95: 13-18 (1980).
23. Hotz J., Ho S.B., Go, V.L.W., Di-Magno, E.P.: Short-term inhibition of duodenal tryptic activity docs not affect human pancreatic, biliary, or gastric function. J. Lab. clin. Med. 101.488-495 (1983).
24. Dlugosz J., Folsch U.R., Creutzfeldt W.: Inhibition of intraduodc-nal trypsin does not stimulate exocrine pancreatic secretion in man. Digestion 26: 197-204 (1983).
25. Funakoshi A., Nakano L., Shinozaki H., Tateishi K., Hamaoka T., Ibayashi H.: High plasma cholccys-tokinin levels in patients with chronic pancreatitis having abdominal pain. Am. J. Gastroent. 81: 1174-1178 (1986).
26. Schafmaycr A., Becker, H.D., Werner, M., Folsch, U.R., Creutzfcldt, W.; Plasma cholecystokinin levels in patients with chronic pancreatitis. Digestion 32:136-139 (1985)
27. Bozkurt T., Adler G., Koop, L., Koop, H., Tiirmcr, W., Arnold, R.; Plasma CCK levels in patients with pancreatic insufficiency. Dig. Dis. Sci. ii: 276-281 (1988).
28. Cantor P., Peironijevic L., Wor-ning H.: Plasma cholccyslokinin Concentrations in palicnls with advanced chronic pancreatitis. Pancreas 1: 488-493 (1986).
29. Mossner J., Back T., Rcgner U., Fischbach W.: Plasma cholccysto-kinin in chronic pancreatitis, Ger. J. Gastroenterol. 27:401-405 (1989).
30. Olsen O., Schaffalitzky de Muckadell, O.B., Cantor, P., Erlanson-Al-bertsson, C., PalnaesHansen, C., Worning, H.; Effect of trypsin on the hormonal regulation of lhc fat-Stimulated human exocrine pancreas. Scand. J. Gastrocnt. 23: 875-881 (1988).
31. Gomez Cerezo J., Codoceo R., Fernandez Calle P., Molina F., Tenias J.M., Vazquez J.J.: Basal and post-prandial cholecystokinin values in chronic pancreatitis with and without abdominal pain. Digestion 48: 134-140 (1991).
32. Campbell D., Jadunandan I., Cu-ringion C., Liddlc R., Solomon T., Toskes P.: Alcoholic and idiopathic patients with painful chronic pancreatitis do not experience suppression of CCK levels or pain relief following treatment with entcric-coated pancreatin. Gastroenterology 102: A259 (1992).
33. Isaksson G., Ihse I.: Pain reduction by an oral pancreatic enzyme preparation in chronic pancreatitis. Dig. Dis. Sci. 2. 97-102 (1983).
34. Halgreen H., Pcdcrscn T.N., Worning H.: Symptomatic effect of pancreatic enzyme therapy in patients with chronic pancreatitis. Scand. J. Gastroent. 21: 104-108 (1986).
35. Mossner J., Wresky H.-P., Kestel W., Zcch J., Regner U., Fischbach W.: Influence of treatment with pancreatic enzymes on pancreatic enzyme secretion.. Gut 30: 1143-1149 (1989).
36. Janscn J.B., Jebbink M.C., Mulders H.J., Lamers C.B.: Effect of pancreatic enzyme supplementation on postprandial plasma cholccysto-kinin secretion in patients with pancreatic insufficiency. Regul. Pept. 25: 333-342 (1989).
37. Van de Kamer J.H., ten Bokkel Huinink H., Weyers H.A.: Rapid method for the determination of fat in faeces. J. biol. Chem. 177: 347-355 (1949).
38. Lankisch P.G., Lembckc B., Kirch-hoff S., Hilgers R., Creulzfeldt W.: Treatment of pancrcatogenic steatorrhea: a comparison of two-acid-protected enzyme preparations. Dt. med. Wschr. 113:15-17 (1988).
39. Lankisch, P.G.; Conservative treatment of chronic pancreatitis. Digestion J7:suppl. I. pp. 47-55 (1987).
40. Ebbehoj, N., Borly, L., Buelow, J., Rasmusscn, S.G., Madsen, P.; Evaluation of pancreatic tissue fluid pressure and pain in chronic pancreatitis. A longitudinal study. Scand. J. Gastroent. 25:462-466 (1990).
41. Ebbehoj N., Borly L., Buelow J., Rasmussen S.G., Madsen P., Mat-zen P., Owre A.: Pancreatic tissue fluid pressure in chronic pancreatitis. Relation to pain, morphology. and function. Scand. J. Gastroent. 25:1046-1051 (1990).
42. Saucrbruch T., Holl J., Sackmann M., Paumgartncr G.: Extracorporeal shock wave lithotripsy of pancreatic stones. Gut 30: 1406-1411 (1989).
43. Wolfson P.: Surgical management of inflammatory disorders of the pancreas. Surgery Gynec. Obstet. 151:689-698 (1980).
44. Beger H.G., Büchler M., Bittner R.R., Oettinger W., Roscher R.: Duodenum-preserving resection of the head of the pancreas in severe chronic pancreatitis. Ann. Surg. 209:273-278 (1989).
45. Bockman D.E., Biichler M., Malferthcincr P., Beger H.G.: Analysis of nerves in chronic pancreatitis. Gastroenterology 94: 1459-1469 (1988).
46. Ammann, R.W., Akovbiantz, A., Largiader, F., Schiiler, G.; Course and outcome of chronic pancreatitis. Longitudinal study of a mixed medical-surgical series of 245 patients. Gastroenterology Sfi: 820-828 (1984).
47. Otte M., Ridder P., Dagefiirde J.: In-vitro tests of pancreatic enzyme preparations, Dt. mcd. Wschr. 112: 1498-1502 (1987).
48. Mössner, J.; Stange, J.; Ewald, M.; Kcstel, W.; Fischbach, W.; Inllucnce of exogenous application of pancreatic extracts on endogenous pancreatic enzyme secretion. Pancreas 6:637-644 (1991).