Decrease in epinephrine-induced attenuation of platelet adenylate cyclase activity in depressed patients: Relation with plasma electrolytes

Neuropsychobiology

Volumn 26, Issue 3, 1992, Pages 129-135

  Karege, Felicien ^a   Bovier, Philippe ^a   Widmer, Jean ^a   Gaillard, Jean Michel ^a   Tissot, René ^a  

^a Institutions Universitaires de Psychiatrie   (Switzerland)

Author keywords

Adenylate cyclase; Depression; Magnesium; Platelet 2< inf> adrenoceptor; Sodium

Indexed keywords

ADENYLATE CYCLASE; ADRENALIN; ALPHA 2 ADRENERGIC RECEPTOR; ELECTROLYTE; FORSKOLIN; MAGNESIUM; SODIUM;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DISEASE SEVERITY; ELECTROLYTE BLOOD LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; MAGNESIUM BLOOD LEVEL; MALE; PRIORITY JOURNAL; SODIUM BLOOD LEVEL; THROMBOCYTE; THROMBOCYTE MEMBRANE;

ADENYLATE CYCLASE; ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; BLOOD PLATELETS; DEPRESSIVE DISORDER; ELECTROLYTES; EPINEPHRINE; FEMALE; HUMAN; IN VITRO; MALE; MIDDLE AGE; RECEPTORS, ADRENERGIC, ALPHA; SUPPORT, NON-U.S. GOV'T;

EID: 0027073333     PISSN: 0302282X     EISSN: 14230224     Source Type: Journal    
DOI: 10.1159/000118908     Document Type: Article

References (34)

1. Schildkraul, JJ. The catecholamine hypothesis of affective disorders: A review of supporting evidence: Am J Psychiatry 1965:122:509-522
2. Tissot, R. Un concept hypothétique: I‚unité physiopathologique des psychoses monoami-nergiques. Ecephale 1975:1:289-339.
3. Starke, K. Regulation of noradrenaline release by presvnaptic receptor systems: in Adrian et al (cds): Reviws of Physiology. Biochemistry and Pharmacology. Berlin. Springer. 1977. vol 77, pp 1-124.
4. Schildkraut, JJ, Keeler, BA, Grab, EL, Kantrovich, J. MHPG excretion and clinical classification in depressive disorders. Lancet 1973: i: 1251-1252.
5. Maas, JW. Clinical and biochemical heterogeneity of depressive disorders. Ann Intern Med 1978: 88:556-563.
6. Garcia-Scvilla, JA, Zis, AP, Hollingsworth, PJ, Greden, JF, Smith, CB. Platelet α2adrenergie receptors in major depressive disorder. Arch Gen Psychiatry 1981:38:1327-1333.
7. Garcia-Scvilla, JA, Guimon, J, Garcia-Vallejo, P, Fuster, MJ. Biochemical and functional evidence of supersensitive platelet α2-adrcnoceptors in major affectivc disorder: Effect of longterm lithium carbonate treatment. Arch Gen Psychiatry 1986:43:51-57.
8. Siever, U, Kafka, MS, Targum, S, Lake, CR. Platelet alpha-adrenergic binding and biochemical responsiveness in depressed patients and controls. Psychiatrv Res 1984:11:287-302.
9. Pletscher, A, Laubscher, A, Graf, M, Saner, A. Blood platelets as models for central 5-hydroxy tryptamincrgic neurons. Ann Biol Clin 1979; 37:35-39.
10. Stahl, SM. Platelers as pharmacologic models for the receptors and biochemistry of monoaminergic neurons: In Longenecker G (ed): The Platelets: Physiology and Pharmacology. London. Academic Press. 1985 chap 13. pp 307-335.
11. Gierschik, P, Jakobs, KH. Mechanisms for inhibition of adenylate cyclase by otiadrenergic receptor: in Limbird LE (ed): The aj-Adrenergic Receptors. Clifton. Humana Press. 1988. chap 3. pp 75-113.
12. Jakobs, KH, Aktorics, K, Schultz, G. Inhibitory coupling of hormone and neurotransmitter receptors to adenylate cyclase. J Recept Res 1983:3:137-149.
13. Aktorics, K, Jakobs, KH. Epinephrine inhibits adenylate cyclase and stimulates a GTPase in human platelet membranes via a-adrenoceptors. FEBS Lett 1981:130:235-238.
14. Ruffolo, JJ, Jr, Nichols, AJ, Hieble, JP. Functions mediated by alpha-2 adrenergic receptors: in Limbird LE (ed): The Alpha-2 Adrenergic Receptors. Clifton, Humana Press. 1988, chap 5. pp 187-280.
15. Lenox, RH, Ellis, J, Van Riper, DA, Ehrlich, YH, Peyser, JM, Shipley, JE, Weaver, LA. Platelet uiadrenergic receptor activity in clinical studies of depression; in Usdin. Goldstein. Friedhoff (eds): Frontiers in Neuropsychiatric Research. New York. Macmillan. 1983. pp 351-356.
16. Kafka, MS, Paul, SM. Platelet α2-adrenergic receptors in depression. Arch Gen Psychiatry 1986:43:91-95.
17. Karege, F, Bovier, P, Gaillard, JM, Tissot, R. Regulation of platelet alphawidrcnoceptors in depression. 5th World Congr Biol Psychiatry, Florence. 1991. Biol Psychiatry 1991 (suppl): 29.
18. Scamon, K, Daly, JW. Activation of adenylate cyclase by the diterpene forskolin does not require the guanine nucleotide regulatory protein. J Biol Chem 1981:256:9799-9801.
19. Insel, PA, Stengel, D, Ferry, N, Hanoune, J. Regulation of adenylate cyclase of human platelet membranes by forskolin. J Biol Chem 1982: 257:7485-7490.
20. Widmer, J, Raffin, Y, Stella, N, Bovier, P, Hilleret, H, Tissot, R. New data on total, ultrafiltrable plasmatic and red blood cell magnesium concentration and other blood electrolytes measured in 25 depressed patients followed during three months. Magnesium Res 1991:4: 235.
21. Ramsey, TA, Frazier, A, Mendels, J. Plasma and erythrocyte cations in affective disorders: sodium and magnesium. Ncuropsychobiology 1979:5:1-10.
22. Steer, MC, Wood, A. Inhibitory effects of sodium and other monovalent cations on human platelet adenylate cyclase. J Biol Chem 1981: 256:9990-9993.
23. Schloss, J, Wellstein, A, Palm, D. Agonist binding at α2-adrenoceptors of human platelets using 3H-UK-14.304: Regulation by Gpp(NH)p and cations. Naunvn-Schmiedebergs Arch Pharmacol 1987; 336:38-59.
24. Bobon, DP. Le systemc AMDP. Manuel de documentation et de quantification de la psychopalhologie, ed 2. Bruxelles. Mardaga. 1981.
25. Carstens, ME, Engelbrecht, AH, Russel, VA, Aalbers, C, Gagiano, CA, Charlton, DO, Taljaard, JJF. Alpha-2-adrenoccptor levels on platelets of patients with major depressive disorders. Psychiatry Res 1986:18:312-331.
26. Cambridge, D. UK-14, 304. a potent and selective alpha-2-agonist for the characterization of alpha-adrenoceptor subtypes. Eur J Pharmacol 1981; 72:413-415.
27. Garcia-Sevilla, JA, Udine, C, Fuster, MJ, Alvarez, E, Casas, M. Enhanced binding of [3H] (-) adrenaline to platelets of depressed patients with melancholia: Effect of long-term clomipramine treatment. Acta Psychiatr 1987:75: 150-157.
28. Takeda, T, Harada, T, Olsuki, S. Platelet 3H-clo-nidine and 3H-imipraminc binding and plasma cortisol level in depression. Biol Psychiatry. 1989:26:52-60.
29. Karege, F, Bovier, Ph, Widmer, J, Gaillard, JM, Tissot, R. Platelet membrane Alpha-2-adrenoceptors in depression. Psychiatry Res 1992, in press.
30. Mooney, JJ, Schatzberg, A, Cole, JO, Kuzuka, PP, Schildkraut, JJ. Enhanced signal transduction by adenylate cyclase in platelet membranes of patients showing antideprcssant responses to Alprazolam: Preliminary data. J Psychiatr Res 1985:19:65-75.
31. Mooney, JJ, Schatzberg, AF, Cole, JO, Kizuka, PP, Salomon, M, Lerbinger, J, Pappalardo, KM, Gerson, B, Schildkraut, JJ. Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase. Biol Psychiatry 1988:23:543-559.
32. Jakbos, KH, Minuth, M, Aktorics, K. Sodium regulation of hormone-sensitive adenylate cyclase. J Recept Res 1984:4:443-458.
33. Mitrius, JC, U'Prichard, DC. Regulation of α2- adrenoceptors by nucleotides, ions, and agonists: comparison in cells of neural and non-neural origin: in Cooper DMF. Seamon KB (eds): Advances in Cyclic Nucleotide and Protein Phosphorylation Research. New York, Raven Press, 1985. vol 19. pp 57-73.
34. Golden, RN, Markey, SP, Risby, ED, Rudorfer, MV, Cowdry, RW, Potter, WZ. Antidepressants reducc whole-body norepinephrine turnover while enhancing 6-hydroxy-melatonin output. Arch Gen Psychiatry 1988:45:150-154.