Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop

Genes and Development

Volumn 6, Issue 12, 1992, Pages 2235-2247

  Stanton, Brian R ^a   Perkins, Archibald S ^a   Tessarollo, Lino ^a   Sassoon, David A ^a,b   Parada, Luis F ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b BOSTON UNIVERSITY   (United States)

Author keywords

Mouse embryogenesis; N myc gene; Postimplantation development

Indexed keywords

MESSENGER RNA;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CENTRAL NERVOUS SYSTEM; EMBRYO; EMBRYO CELL; EMBRYO DEVELOPMENT; EPITHELIUM; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE FUNCTION; GENE MUTATION; HETEROZYGOTE; HISTOLOGY; IN SITU HYBRIDIZATION; INTESTINE; LETHAL GENE; LUNG; MESENCHYME; MESONEPHROS; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEUROEPITHELIUM; NIDATION; NONHUMAN; ONCOGENE C MYC; ONCOGENE MYC; PERIPHERAL NERVOUS SYSTEM; PRIORITY JOURNAL; TISSUE SPECIFICITY;

ALLELES; ANIMAL; BLOTTING, SOUTHERN; EMBRYO AND FETAL DEVELOPMENT; EPITHELIUM; FETAL DEATH; GENE EXPRESSION REGULATION; GENES, MYC; GENOTYPE; HETEROZYGOTE; INTESTINES; LUNG; MICE; MULTIGENE FAMILY; MUTAGENESIS, SITE-DIRECTED; NERVOUS SYSTEM; STOMACH; SUPPORT, U.S. GOV'T, P.H.S.; TRANSCRIPTION, GENETIC; UROGENITAL SYSTEM;

EID: 0027066738     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.6.12a.2235     Document Type: Article

References (57)

1. Baumbach, W.R., E.M. Colston, and M.D. Cole. 1988. Integration of the Balb/c ecotropic provirus into the colony-stimulating factor-1 growth factor locus in a myc retrovirus-induced murine monocyte tumor. J. Virol. 62: 3151-3155.
2. Blackwood, E.M. and R.N. Eisenman. 1991. Max: A helix-loop-helix protein that activates transcription through the immunoglobulin enhancer mE3 motif. Genes & Dev. 4: 167-179.
3. Bock, G. and J. Marsh, eds. 1990. Proto-oncogenes in cell development. Ciba Foundation Symposium 150. John Wiley and Sons, Ltd. New York.
4. Brodeur G.M., R.C. Seeger, M. Schwab, H.E. Varmus, and J.M. Bishop. 1984. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224: 1121-1124.
5. Brown, N.A. 1990. Routine assessment of morphology and growth: Scoring systems and measurement of size. In Postimplantation mammalian embryos: A practical approach. (ed. A.J. Copp and D.L. Cockroft), pp. 93-1108. IRL/Oxford University Press, New York.
6. Büeler, H., M. Fischer, Y. Lang, H. Bluethmann, H.-P. Lipp, S.J. DeArmond, S.B. Prusiner, M. Aguet, and C. Weissmann. 1992. Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature 356: 577-581.
7. Capecchi, M.R. 1989. Altering the genome by homologous recombination. Science 244: 1288-1292.
8. Cohn, S.L., H. Salwen, M.W. Quansney, N. Ikegaki, J.M. Cowan, C.V. Herst, R.H. Kennett, S.T. Rosen, J.A. DiGiuseppe, and G.M. Brodeur. 1990. Prolonged N-myc half-life in a neuroblastoma cell line lacking N-myc amplification. Oncogene 5: 1821-1827.
9. Cole, M.D. 1986. The myc oncogene: Its role in transformation and differentiation. Annu. Rev. Genet. 20: 361-384.
10. DePinho, R.A., E. Legouy, L.B. Feldman, N.E. Kohl, G.D. Yancopolous, and F.W. Alt. 1986. Structure and expression of the murine N-myc gene. Proc. Natl. Acad. Sci. 83: 1827-1831.
11. Dildrop, R., K. Zimmerman, R.A. DePinho, G.D. Yancopoulos, A. Tesfaye, and F.W. Alt. 1988. Differential expression of myc-family genes during development: Normal and deregulated N-myc expression in transgenic mice. Curr. Top. Microbiol. Immunol. 141: 100-109.
12. Downs, K.M., G.R. Martin, and J.M. Bishop. 1989. Contrasting patterns of myc and N-myc expression during gastrulation of the mouse embryo. Genes & Dev. 3: 860-869.
13. Gossler, A., T. Doetschman, R. Korn, E. Serfling, and R. Kemler. 1986. Transgenesis by means of blastocyst-derived embryonic stem cell lines. Proc. Natl. Acad. Sci. 83: 9065-9069.
14. Grady, E.F., M. Schwab, and W. Rosenau. 1987. Expression of N myc and c-src during development of fetal human brain. Cancer Res. 47: 2933-2936.
15. Hogan, B., F. Constantini, and E. Lacy. 1986. Manipulating the mouse embryo: A laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New York.
16. Jakobovitz, A., M. Schwab, J.M. Bishop, and G.R. Martin. 1985. Expression of N myc in teratocarcinoma stem cells and mouse embryos. Nature 318: 188-191.
17. Jenkins, N.A., N.G. Copeland, B.A. Taylor, and B.K. Lee. 1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA in chromosomes of Mus musculus. J. Virol. 43: 26-36.
18. Kerkhoff, E., K. Bister, and K.H. Klempnauer. 1991. Sequence specific DNA binding by myc proteins. Proc. Natl. Acad. Sci. 88: 4323-4327.
19. Kohl, N.E., N. Kanda, R.R. Schrenk, G. Bruns, S.A. Latt, F. Gilbert, and F.W. Alt. 1983. Transposition and amplification of oncogene related sequences in human neuroblastomas. Cell 35: 3659-3673.
20. Kohl, N.E., C.E. Gee, and F.W. Alt. 1984. Activated expression of the N myc gene in human neuroblastomas and related tumors. Science 226: 1335-1337.
21. Kohl, N.E., E. Legouy, R. DePinho, P. Nisen, R. Smith, C. Gee, and F.W. Alt. 1986. Human N myc is closely related in organization and nucleotide sequence to c-myc. Nature 319: 73-77.
22. Kreig, P.A. and D.A. Melton. 1987. In vitro RNA synthesis with SP6 RNA polymerase. Methods Enzymol. 155: 397-415.
23. Landschulz, W., P. Johnson, and S. McKnight. 1988. The leucine zipper: A hypothetical structure common to a new class of DNA binding proteins. Science 240: 1759-1764.
24. Lee, W.H., A.L. Murphree, and W.F. Benedict. 1984. Expression and amplification of the N myc gene in primary retinoblastoma and related tumors. Nature 309: 458-460.
25. LeMouellic, H., H. Candamine, and P. Brulet. 1988. Patterns of transcription of the homeo gene Hox-3.1 in the mouse embryo. Genes & Dev. 2: 125-135.
26. Martin-Zanca, D., M. Barbacid, and L.F. Parada. 1990. Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes & Dev. 4: 683-694.
27. Moens, C.B., A.B. Auerbach, R.A. Conlon, A.L. Joyner, and J. Rossant. 1992. A targeted mutation reveals a role for N-myc in branching morphogenesis in the embryonic mouse lung. Genes & Dev. 6: 691-704.
28. Mugrauer, F., F.W. Alt, and P. Ekblom. 1988. N myc proto-oncogene expression during organogenesis in the developing mouse as revealed by in situ hybridization. J. Cell Biol. 107: 1325-1335.
29. Muller, R., D.J. Slamon, J.M. Tremblay, M.J. Cline, and I.M. Verma. 1982. Differential expression of cellular oncogenes during pre- and postnatal development of the mouse. Nature 299: 640-649.
30. Murré, C., P. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, myoD and myc proteins. Cell 56: 777-783.
31. Nau, M.M., B.J. Brooks, J. Battey, E. Sausville, A.F. Gazdar, I.R. Kirsch, O.W. McBride, V. Bertness, G.F. Hollis, and J.D. Minna. 1985. L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer. Nature 318: 69-73.
32. Nau, M.M., B. Brooks, D. Carney, D. Gazdar, J. Battey, E. Sausville, and J. Minna. 1986. Human small-cell lung cancers show amplification and expression of the N myc gene. Proc. Natl. Acad. Sci. 83: 1092-1096.
33. Nisen P.D., P.G. Waber, M.A. Rich, S. Pierce, J.R. Garvin, F. Gilbert, and P. Lanzkowsky. 1988. N-myc oncogene RNA expression in neuroblastoma. J. Natl. Cancer Inst. 80: 1633-1637.
34. Pfeifer-Ohlsson, S., J. Rydnert, A.S. Goustin, E. Larsson, C. Betsholtz, and R. Ohlsson. 1985. Cell-type specific pattern of myc proto-oncogene expression in developing human embryos. Proc. Natl Acad. Sci. 82: 5050-5054.
35. Prendergast, G.C. and E.B. Ziff. 1991. Methylation-sensitive sequence-specific DNA binding by the c-myc basic region. Science 251: 186-189.
36. Prendergast, G.C., D. Lawe, and E.B. Ziff. 1991. Association of Myn, the murine homolog of Max, with c-myc stimulates methylation-sensitive DNA binding and Ras co-transformation. Cell 65: 395-407.
37. Ramsey, T., L. Stanton, M. Schwab, and J.M. Bishop. 1987. Human proto-oncogene N myc encodes nuclear proteins that bind DNA. Mol. Cell. Biol. 6: 4450-4457.
38. Robertson, E.J. 1991. Using embryonic stem cells to introduce mutations into the mouse germ line. Biol. Reprod. 44: 238-245.
39. Rosenbaum, H., E. Webb, J.M. Adams, S. Cory, and A.W. Harris. 1989. N-myc transgene promotes B lymphoid proliferation, elicits lymphomas and reveals cross-regulation with c-myc. EMBO J. 8: 749-755.
40. Rossant, J. and A.L. Joyner. 1989. Towards a molecular-genetic analysis of mammalian development. Trends Genet. 5: 277-283.
41. Rugh, R. 1968. The mouse: Its reproduction and development. p. 302. Burgess Publishing Co., Minneapolis, MN.
42. Sawai, S., A. Shimono, K. Hanaoko, and H. Kondoh. 1991. Embryonic lethality resulting from disruption of both N-myc alleles in mouse zygotes. New Biol. 3: 861-869.
43. Schwab, M., K. Alitalo, K.-H. Klempnauer, H.E. Varmus, J.M. Bishop, G. Brodeur, M. Goldstein, and J. Trent. 1983. Amplified DNA with limited homology to myc cellular oncogene shared by human neuroblastoma cell lines and a neuroblastoma tumor. Nature 305: 245-248.
44. Schwab, M., J. Ellison, M. Busch, W. Rosenau, H.E. Varmus, and J.M. Bishop. 1984. Enhanced expression of the human gene N myc consequent to amplification of DNA may contribute to malignant progression of neuroblastoma. Proc. Natl. Acad. Sci. 81: 4940-4944.
45. m1 mutation show poor viability and depletion of selected B and T cell populations. Cell 65: 1165-1172.
46. Slamon, D.J., T.C. Boone, R.C. Seeger, D.E. Keith, V. Chazin, H.C. Lee, and L.M. Souza. 1986. Identification and characterization of the protein encoded by the human N myc oncogene. Science 232: 768-772.
47. Soriano, P., C. Montgomery, R. Geske, A. Bradley. 1991. Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice. Cell 64: 693-702.
48. Stanton, B.R. and L.F. Parada. 1992. The N-myc proto-oncogene: Developmental expression and in vivo site-directed mutagenesis. Brain Path. 2: 71-83.
49. Stanton, L., M. Schwab, and J.M. Bishop. 1986. Nucleotide sequence of the human N myc gene. Proc. Natl. Acad. Sci. 83: 1772-1776.
50. Stanton, B.R., S.W. Reid, and L.F. Parada. 1990. Germ line transmission of an inactive N myc allele generated by homologous recombination in mouse embryonic stem cells. Mol. Cell. Biol. 10: 6755-6758.
51. Tessarollo, L., L. Nagarajan, and L.F. Parada. 1992. c-ros: The vertebrate homolog of the sevenless tyrosine kinase receptor is tightly regulated during organogenesis in mouse development. Development 115: 11-20.
52. Thiele, C.J., L. Cazenave, J.B. Bolen, and M.A. Israel. 1988. Developmentally regulated genes in neuroblastoma. Prog. Clin. Biol. Res. 271: 185-194.
53. Tybülewicz, V.L.J., C.E. Crawford, P.K. Jackson, R.T. Bronson, and R.C. Mulligan. 1991. Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene. Cell 65: 1153-1163.
54. Vennstrom, B., D. Sheiness, f. Zabielski, and J.M. Bishop 1982. Isolation and characterization of c-myc, a cellular homolog of the oncogene (v-myc) of avian myelocytomatosis virus strain 29. J. Virol. 42: 773-776.
55. + cytolytic T cells. Nature 344: 742-746.
56. Zimmerman, K. and F.W. Alt. 1990. Expression and function of myc family genes. Crit. Rev. Oncol. 2: 75-95.
57. Zimmerman, K., G. Yancopolous, R. Collum, R. Smith, N.E. Kohl, K. Denis, M. Nau, O. Witte, D. Toran-Allerand, C. Gee, J. Minna, and F.W. Alt. 1986. Differential expression of myc family genes during murine development. Nature 319: 780-783.