Synthesis and aldose reductase inhibitory activity of substituted 2(1H)-benzimidazolone- and oxindole-1-acetic acids

European Journal of Medicinal Chemistry

Volumn 27, Issue 8, 1992, Pages 779-789

  Howard, HR ^a   Sarges, R ^a   Siegel, TW ^a   Beyer, TA ^a  

^a PFIZER INC   (United States)

Author keywords

2(1H) benzimidazolone 1 acetic acid; aldose reductase; diabetes; oxindole 1 acetic acid

Indexed keywords

3 (3,4 DICHLOROBENZYL) 2,3 DIHYDRO 2 OXO 1 BENZIMIDAZOLEACETIC ACID; 3,3 BIS(3,4 DICHLOROBENZYL)OXINDOLE 1 ACETIC ACID; ACETIC ACID DERIVATIVE; ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; BENZIMIDAZOLE DERIVATIVE; ENZYME INHIBITOR; INDOLE DERIVATIVE; PONALRESTAT; SORBINIL; SORBITOL; UNCLASSIFIED DRUG; ZOPOLRESTAT;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG SYNTHESIS; EYE; HUMAN; HUMAN TISSUE; LENS; NONHUMAN; ORAL DRUG ADMINISTRATION; PLACENTA; PRIORITY JOURNAL; RAT; SCIATIC NERVE; STRUCTURE ACTIVITY RELATION;

EID: 0027055739     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(92)90112-E     Document Type: Article

References (51)

1. Complications of diabetes: Prevalence, detection, current treatment, and prognosis
2. Aldose reductase inhibitors: pharmacological data and therapeutic perspectives
3. Synthesis and aldose reductase inhibitory activity of N-acylthiazolidinecarboxylic acids.
4. 58. The reaction of o-phenylenediamine with ??-unsaturated acids and with ?-keto-esters
5. Third SCI-RSC Med Chem Symposium
6. 59. Some N-substituted 2-oxobenzimidazolines
7. 126. The preparation and properties of 2-substituted isoarsindolines and of As-spiro-Bisisoarsindolinium salts