A qualitative assessment of developmental toxicity within a series of structurally related dopamine mimetics

Toxicology

Volumn 76, Issue 3, 1992, Pages 197-207

  Ridings, James E ^a   Baldwin, John A ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Domanine mimetics; Structure activity relationships; Terategencity

Indexed keywords

7 (2 DIMETHYLAMINOETHOXY) 2,2 DIMETHYL 4 [3 (TRIFLUOROMETHYL)PHENYL]CHROMAN; BRL 16657; DOPAMINE; DOPAMINE RECEPTOR STIMULATING AGENT; DRUG ANALOG; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION; TERATOGENICITY;

ABNORMALITIES, DRUG-INDUCED; ANIMAL; BODY WEIGHT; CHROMANS; DOPAMINE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; MALE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027054156     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(92)90189-L     Document Type: Article

References (4)

1. Teratogenecity in rats of two dopaminergic agonists
2. 4-Substituted chromas as potential antidepressant agents
3. BRL 16644, an inhibitor of monoamine uptake in vitro, with a long duration of action, in vivo
4. Multivariate quantitative structure-toxicity relationships in a series of dopamine mimetics