Synthesis, Configuration, and Activity of Isomeric 2-Phenyl-2-(N-piperidinyl)bicyclo[3.1.0]hexanes at Phencyclidine and σ Binding Sites

Journal of Medicinal Chemistry

Volumn 35, Issue 25, 1992, Pages 4704-4712

  de Costa, Brian R ^a,b,c   Mattson, Mariana V ^a,b,c   George, Clifford ^a,b   Linders, Joannes T M ^a,b,c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NAVAL RESEARCH LABORATORY   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 PHENYL 2 BICYCLO[3.1.0]HEXYL)PIPERIDINE; PHENCYCLIDINE; PHENCYCLIDINE RECEPTOR; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTALLIZATION; DRUG ACTIVITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GEOMETRY; OPTICAL RESOLUTION; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

ANIMAL; BICYCLO COMPOUNDS; BINDING SITES; BRAIN; GUINEA PIGS; HEXANES; MALE; MODELS, MOLECULAR; PHENCYCLIDINE; PIPERIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECEPTORS, PHENCYCLIDINE; RECEPTORS, SIGMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027050269     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00103a008     Document Type: Article

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