The GCN4 basic region leucine zipper binds DNA as a dimer of uninterrupted α Helices: Crystal structure of the protein-DNA complex

Cell

Volumn 71, Issue 7, 1992, Pages 1223-1237

  Ellenberger, Thomas E ^a   Brandl, Christopher J ^b   Struhl, Kevin ^b   Harrison, Stephen C ^a,c  

^a HARVARD UNIVERSITY   (United States)

^b Department of Biological Chemistry and Molecular Pharmacology Boston ^*  (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; LEUCINE ZIPPER PROTEIN;

ARTICLE; CRYSTAL STRUCTURE; DIMERIZATION; DNA BINDING; DNA HELIX; DNA PROTEIN COMPLEX; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL;

AMINO ACID SEQUENCE; BASE SEQUENCE; CRYSTALLOGRAPHY; DNA-BINDING PROTEINS; FUNGAL PROTEINS; LEUCINE ZIPPERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EUKARYOTA;

EID: 0027049805     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(05)80070-4     Document Type: Article

References (54)

1. Identification of an amino acid-base pair contact in the GCN4-DNA complex by bromouracil-mediated photocrosslinking
2. Human proto-oncogene c-jiu encodes a DNA binding protein with structural and functional properties of transcription factor AP-1
3. Equilibrium dissociation and unfolding of the arc repressor dimer
4. Methods and programs for direct-space exploitation of geometric redundancies
5. The DNA binding arm of λ repressor: critical contacts from a flexible region
6. Analysis of dimerization and DNA-binding functions in Fos and Jun by domain-swapping: involvement of residues outside the leucine zipper/basic region
7. The packing of α-helices simple coiled-coils
8. The Fos complex and Fos-related antigens recognize sequence elements contain AP-1 binding sites
9. Molecular characterization of the GCN4-DNA complex
10. Parallel association of Fos and Jun leucine zippers juxtaposes DNA-binding domains
11. A family of immunologically related transcription factors that includes multiple forms of ATF and AP-1
12. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers
13. DNA recognition by proteins with the helix-turn-helix motif
14. Saturation mutagenesis of the yeast his3 regulatory site: requirements for transcriptional induction and for binding by GCN4 activation protein
15. Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of yeast
16. Eukaryotic transcriptional regulatory proteins
17. Evaluation of single crystal X-ray diffraction data from a position-sensitive detector
18. Zinc-finger structures
19. Transcription factor interactions: basics on zippers
20. Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity
21. DNA bending by Fos and Jun: the flexible hinge model
22. Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions
23. The role of the leucine zipper in the Fos-Jun interaction
24. Structural motif of the GCN4 DNA binding domain characterized by affinity cleaving
25. Defining sequence specificity of DNA-binding proteins by selecting binding sites from random-sequence oligonucleotides: analysis of the yeast GCN4 protein
26. Design of DNA binding peptides based on the leucine zipper motif
27. DNA-induced incease in the α-helical content of C/EBP and GCN4
28. Evidence that the leucine zipper is a coiled coil
29. X-ray structure of the GCN4 leucine zipper, a two-stranded, parallel coiled coil
30. Mechanism of specificity in the Fos-Jun oncoprotein heterodimer
31. Altered protein conformation on DNA binding by Fos and Jun
32. Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 Å
33. Uracil interference, a rapid and general method for defining protein-DNA interactions involving the 5-methyl group of thymines: the GCN4-DNA complex
34. Common DNA binding site for Fos protein complexes and transcription factor AP-1
35. Asymmetrical recognition of the palindromic AP1 binding site (TRE) by Fos protein complexes
36. Gin and ATP at 2.8 Å resolution
37. Solution structure of the basic region from the transcriptional activator GCN4
38. Non-leucine residues in the leucine repeats of Fos and Jun contribute to the stability and determine the specificity of dimerization
39. Sequencespecific recognition of double helical nucleic acids by proteins
40. Changing Fos oncoprotein to a Jun-independent DNA-binding protein with GCN4 dimerization specificity by swapping leucine zippers
41. Mutations that define the optimal half site for binding yeast GCN4 activator proteins and identify an ATF/CREB-like repressor that recognizes similar DNA sites
42. Different requirements for formation of Jun: Jun and Jun: Fos complexes
43. The DNA-bind domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous
44. Sequencespecific DNA binding by a short peptide dimer
45. Unbiased three-dimensional refinement of heavy-atom parameters by correlation of originremoved Patterson functions
46. An efficient general-purpose least-squares refinement program for macromolecular structures
47. Leucine repeats and an adjacent DNA-binding domain mediate the formation of functional c-fos-c-jun heterodimers
48. Mutation in the bZIP domain of yeast GCN4 that alter DNA-binding specificity
49. Scissors-grip model for DNA recognition by a family of leucine zipper proteins
50. Thermal unfolding studies of a leucine zipper domain and its specific DNA complex: implications for scissors' grip recognition
51. 1H NMR with application to phage λ repressor
52. Folding transition in the DNA-binding domain of GCN4 on specific binding to DNA
53. Crystal structure of a MAT α2 homeodomain-operator complex suggests a general model for homeodomain-DNA interactions