-
1
-
-
0002765558
-
Transposable Elements in Saccharomyces cerevisiae
-
DE Berg, MM Howe, American Society for Microbiology, Washington DC
-
(1989)
Mobile DNA
, pp. 335-374
-
-
Boeke1
-
2
-
-
0026591664
-
Symmetry, Flexibility and Permeability in the Structure of Yeast Retrotransposon Virus-Like Particles
-
of special interest, The first detailed report of the structure of virus-like particles produced by a transposable element. The authors show that these particles are more variable in structure than those of retroviruses.
-
(1992)
EMBO J
, vol.11
, pp. 1155-1164
-
-
Burns1
Saibil2
White3
Pardon4
Timmins5
Richardson6
Kingsman7
Kingsman8
-
3
-
-
0025837880
-
Identification of an Unusual Structure in the Drosophila melanogaster Transposable Element copia: Evidence for copia Transposition Through an RNA Intermediate
-
of special interest, Direct evidence that a retrovirus-like element in Drosophila transposes by reverse transcription of an RNA intermediate. The data suggest that the RNA transposition intermediates of copia elements contain a sequence that favours packaging into virus-like particles.
-
(1991)
Gene
, vol.103
, pp. 179-184
-
-
Yoshioki1
Kanda2
Akiba3
Enoki4
Shiba5
-
5
-
-
0025908033
-
An Indicator Gene for Detection of Germline Retrotransposition in Transgenic Drosophila Demonstrates RNA-Mediated Transposition of the LINE I Element
-
(1991)
EMBO J
, vol.10
, pp. 1927-1991
-
-
Jensen1
Heidmann2
-
6
-
-
0025939207
-
Retrotransposition of a Mouse L1 Element
-
of special interest, The first direct evidence that mammalian LINE elements transpose through an RNA intermediate, as well as the first report of these elements transposing in an experimental situation.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8792-8795
-
-
Evans1
Palmiter2
-
7
-
-
0025866057
-
Authentic Reverse Transcriptase is Coded by jockey, a Mobile Drosophila Element Related to Mammalian LINEs
-
of special interest, Direct evidence that the pol-like ORF of a Drosophila retrovirus-like element encodes a reverse transcriptase. Most of the pol-like gene was expressed in E. coli and encoded a protein with reverse transcriptase but not RNAse H activity.
-
(1991)
EMBO J
, vol.10
, pp. 2489-2495
-
-
Ivanov1
Melnikov2
Siunov3
Fodor4
Ilyin5
-
8
-
-
0026046425
-
Reverse Transcriptase Encoded by a Retrotransposon from the Trypanosomatid Crythidia fasciculata
-
of special interest, Direct evidence that a LINE-like element encodes a reverse transcriptase. In this case, the reverse transcriptase coding region of a Ty1 element is replaced by the equivalent region derived from a CRE1 element. The Ty1 element used is transcribed from an inducible promoter, thus enabling high levels of expression. The resulting hybrid Ty1-CRE virus-like particles are associated with a reverse transcriptase activity that is abolished when the CRE sequences are mutated.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 9794-9798
-
-
Gabriel1
Boeke2
-
9
-
-
0026428975
-
Reverse Transcriptase Encoded by a Human Transposable Element
-
of special interest, Direct evidence for a reverse transcriptase encoded by a human L1 element. The method used and results obtained are similar to those described in [8]. An epitope tag is used to detect the Ty1-L1 fusion polypeptide in the virus-like particles.
-
(1991)
Science
, vol.254
, pp. 1808-1810
-
-
Mathias1
Scott2
Kazazian3
Boeke4
Gabriel5
-
10
-
-
0026331048
-
Isolation of an Active Human Transposable Element
-
of special interest, Description of the cloning of a potentially active human L1 element. This appears to have been the donor of a truncated element found inserted within the Factor VIII gene of a haemophiliac patient.
-
(1991)
Science
, vol.254
, pp. 1805-1807
-
-
Dombroski1
Mathias2
Nanthakumar3
Scott4
Kazazian5
-
11
-
-
0024297806
-
jockey, a Mobile Drosophila Element Similar to Mammalian LINEs, is Transcribed from the Internal Promoter by RNA Polymerase II
-
(1988)
Cell
, vol.54
, pp. 685-691
-
-
Mizrokhi1
Georgieva2
Ilyin3
-
12
-
-
0025938190
-
Convergent Transcription Initiates from Oppositely Oriented Promoters within the 5′ End Regions of Drosophila melanogaster F Elements
-
of special interest, Describes an analysis of the promoter of the Drosophila LINE-like element F. Sequences from the beginning of an F element are linked to a chloramphenicol acetyl transferase reporter gene and assayed in transfected cells. The results are complex but provide evidence for a promoter lying within the transcribed region and initiating transcription near the start of the element. A promoter that transcribes in the opposite direction is also observed.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 5171-5180
-
-
Minchiotti1
di Nocera2
-
13
-
-
0025740894
-
Ribonucleoprotein Particles with LINE-1 RNA in Mouse Embryonal Carcinoma Cells
-
of special interest, A concise paper that details convincing evidence for there being ribonucleoprotein particles, which contain L1 RNA and proteins, in mouse embryonic carcinoma cells.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 4804-4807
-
-
Martin1
-
14
-
-
0025007676
-
Reverse Transcriptase Activity from Human Embryonal Carcinoma Cells NTera2D1
-
(1990)
EMBO J
, vol.9
, pp. 3363-3368
-
-
Deragon1
Sinnett2
Labuda3
-
16
-
-
0025911348
-
The Origin of Footprints of the Tc1 Transposon of Caenorhabditis elegans
-
(1991)
EMBO J
, vol.10
, pp. 1919-1925
-
-
Plasterk1
-
17
-
-
0026638840
-
P Element Transposition In Vitro Proceeds by a Cut-and-Paste Mechanism and Use GTP as a Cofactor
-
2+ and GTP but not dNTPs. The donor P element must have intact transposase-binding sites at both ends but can be linear or circular. Linear molecules that end at the P termini can act as donors provided that they have 3′OH groups. This is a major step forward to understanding the mechanisms by which elements of this type transpose.
-
(1992)
Cell
, vol.69
, pp. 27-39
-
-
Kaufman1
Rio2
-
18
-
-
0001785298
-
Evolutionary Conservation of Developmental Mechanisms: DNA Elimination in Drosophila
-
A Spradling, Wiley-Liss, New York, of outstanding interest, This stimulating paper discusses the possibility that the elimination of DNA from chromosomes in somatic cells is not a rarity. The authors suggest that this phenomenon may explain the under-representation of some sequences in polytene chromosomes, and that it may both contribute to position effect variegation and influence gene expression. These ideas are based in part on the authors' study of the behaviour of a mini-chromosome in D. melanogaster.
-
(1992)
Evolutionary Conservation of Developmental Mechanisms
, pp. 39-53
-
-
Spradling1
Karpen2
Glaser3
Zhang4
-
19
-
-
0026541882
-
Altering the Insertional Specificity of a Drosophila Transposable Element
-
of special interest, Describes the behaviour of a P element carrying regulatory sequences from the Drosophila engrailed gene. The results indicate that the integration of P transformation vectors can be influenced by the sequences that they carry. This may help clarify the mechanism of target-site selection by transposable elements and factors that influence the organization of DNA sequences within nuclei.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 1919-1923
-
-
Kassis1
Noll2
VanSickle3
Odenwald4
Perrimon5
-
20
-
-
0025879563
-
Regulation of Drosophila P Element Transposition
-
of outstanding interest, An excellent discussion of the regulation of P element transposition, which is subject to both tissue-specific and genetic controls. Transposition is restricted to the germ-line because a splicing event that is required for transposase production is inhibited in somatic cells. The factors that regulate transposition in germ-cells, as well as their inheritance, are less well understood.
-
(1991)
Trends Genet
, vol.7
, pp. 282-287
-
-
Rio1
-
22
-
-
84912926794
-
P Cytotype Repression of the P Promoter is Exclusively Maternal in the Germline: A Model for P Cytotype
-
of special interest, in press, Describes the use of P-lacZ fusion genes to investigate how P elements are regulated. These experiments show that in strains carrying complete P elements lacZ expression is inhibited more strongly in germ cells than in somatic cells. The factors influencing expression in germ cells are inherited maternally, whereas those affecting somatic expression are not. The authors suggest an interesting model to explain these results.
-
(1992)
Genetics
-
-
Lemaitre1
Ronsseray2
Coen3
-
23
-
-
0025771471
-
Regulation of Retrotransposition in Saccharomyces cerevisiae
-
of outstanding interest, An excellent discussion of the factors influencing the activity of Ty elements in S. cerevisiae. This work shows that transposition is influenced by factors acting at many stages in the transposition cycle.
-
(1991)
Mol Microbiol
, vol.5
, pp. 1823-1829
-
-
Curcio1
Garfinkel2
-
24
-
-
0026636672
-
Posttranslational Control of Ty1 Retrotransposition Occurs at the Level of Protein Processing
-
of special interest, Describes experiments that indicate that Ty1 transposition may be regulated by the rate at which primary translation products are processed and by the stability of the polypeptides derived from them.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 2813-2825
-
-
Curcio1
Garfinkel2
-
26
-
-
0025941898
-
Transposition of Mobile Elements gypsy (mdg4) and hobo in Germ-Line and Somatic Cells of a Genetically Unstable Mutator Strain of Drosophila melanogaster
-
of special interest, Gives a detailed analysis of the behaviour of gypsy and hobo transposable elements in the unstable strain MS of D. melanogaster.
-
(1991)
Mol Gen Genet
, vol.229
, pp. 437-444
-
-
Kim1
Belyaeva2
-
27
-
-
0026548161
-
Inducible Cell Abalation in Drosophila by Cold-Sensitive Ricin A Chain
-
of outstanding interest, Describes a potentially powerful method for killing specific cells at defined times during Drosophila development. This involves placing cold-sensitive mutants of the ricin A-chain under the control of the P-element promoter in environments that restrict its expression to specific cell types. The activity of the toxin is then controlled by changing the ambient temperature.
-
(1992)
Development
, vol.114
, pp. 681-687
-
-
Moffat1
Gould2
Smith3
O'Kane4
-
28
-
-
0026574267
-
Isolation of Temperature-Sensitive Diphtheria Toxins in Yeast and their Effects on Drosophila Cells
-
of outstanding interest, A similar technique to that described in [27]. Describes a method for inducible cell ablation using a temperature-sensitive mutant of the catalytic subunit of diphtheria toxin.
-
(1992)
Development
, vol.114
, pp. 787-796
-
-
Bellen1
D'Evelyn2
Harvey3
Elledge4
-
29
-
-
0026418313
-
Targeted gene Replacement in Drosophila via P Element-Induced Gap Repair
-
of outstanding interest, Describes a novel method for targeting specific base changes in Drosophila genes at their normal chromosomal location. Previously, this has not been possible. The technique makes use of repair synthesis following excision of P elements from a target gene.
-
(1991)
Science
, vol.253
, pp. 1110-1117
-
-
Gloor1
Nassie2
Johnson-Schijtz3
Preston4
Engels5
-
30
-
-
0026526771
-
Targeted Alterations of the Caenorhabditis elegans Genome by Transgene Instructed DNA Double Stranded Break Repair Following Tc1 Excision
-
of outstanding interest, A demonstration that repair synthesis following Tc1 excision can be used to target base changes within the genome of C. elegans. This has previously been described for Drosophila (see [29]).
-
(1992)
EMBO J
, vol.11
, pp. 287-290
-
-
Plasterk1
Groenen2
-
31
-
-
0026584289
-
Oligonucleotide-Directed Site-Specific Mutagenesis in Drosophila melanogaster
-
of special interest, Details experiments that indicate that oligonucleotides injected into Drosophila embryos may be used as templates for repair synthesis following the excision of P elements. The data presented do not exclude the possibility that oligonucleotides could be used to introduce base changes into chromosomal DNA even in the absence of P element excision.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 1735-1739
-
-
Banga1
Boyd2
-
32
-
-
0024505998
-
Eukaryotic Transposable Elements and Genome Evolution
-
(1989)
Trends Genet
, vol.5
, pp. 103-107
-
-
Finnegan1
-
33
-
-
0015495926
-
Nuclear DNA Content and Minimum Generation Time in Herbaceous Plants
-
(1972)
Proc Roy Soc ser B
, vol.181
, pp. 109-1335
-
-
Bennett1
-
34
-
-
84912928813
-
An Abundant LINE-like Element Amplified in the Genome of Lilium speciosum
-
of special interest, in press, A description of an unusually abundant LINE-like element in Lilium.
-
(1992)
Mol Gen Genet
-
-
Leeton1
Smyth2
-
35
-
-
0025886692
-
Tec2, a Second Transposon-Like Element Demonstrating Developmentally Programmed Excision in Euplotes crassus
-
of special interest, A description of a putative Class II element responsible for DNA rearrangements associated with the activation of micronuclear genes during formation of the macronucleus in a ciliated protozoan.
-
(1991)
Mol Cell Biol
, vol.11
, pp. 4751-4759
-
-
Kirkau1
Jahn2
-
36
-
-
0026759776
-
HeT-A, a Transposable Element Specifically Involved in ‘Healing’ Broken Chromosome Ends in Drosophila
-
of special interest, A comparison of the sequences of four copies of a putative LINE-like element, HeT-A, that may be required for telomere function in D. melanogaster.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 3910-3918
-
-
Biessmann1
Valgeirsdottir2
Lofsky3
Chin4
Ginther5
Levis6
Pardue7
-
37
-
-
0026481992
-
Frequent Transpositions of Drosophila melanogaster HeT-A Transposable Elements to Receding Chromosome Ends
-
of outstanding interest, in press, A description both of the behaviour of HeT-A elements located at the end of a broken X chromosome in D. melanogaster and of how they change with time. These elements appear to insert at the broken end, thus preventing its gradual erosion. Analysis of the sequence of one of the elements found at the broken end strengthens the idea that this is a family of LINE-like elements.
-
(1992)
EMBO J
-
-
Biessmann1
Champion2
O'Hair3
Ikenaga4
Kasravi5
Mason6
-
38
-
-
77956714450
-
Do Some ‘Parasitic’ DNA Elements Earn an Honest Living?
-
of special interest, N Fedoroff, D Botstein, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, in press, A personal account of the history of HeT-A elements set in the context of McClintock's studies of chromosomal instabilities in maize.
-
(1992)
The Dynamic Genome
-
-
Pardue1
|
