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1
-
-
0026601317
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Two Myogenic Lineages within the Developing Somite
-
of outstanding interest, Elegant demonstration using chick-quail grafts that the medial and lateral halves of the early avian somite represent distinct myogenic lira eages. These gave rise to the body and limb musculature, respectively, in reciprocal grafting experiments, although in early somites the two halves were interchangeable.
-
(1992)
Development
, vol.114
, pp. 339-353
-
-
Ordahl1
Le Douarin2
-
2
-
-
0025857365
-
Fate Mapping and Cell Lineage Analysis of Hensen's Node in the Chick Embryo
-
(1991)
Development
, vol.112
, pp. 615-626
-
-
Selleck1
Stern2
-
3
-
-
0026733698
-
The Neural Tube/Notochord Complex is Necessary for Vertebral but not Limb and Body Wall Striated Muscle Differentiation
-
of outstanding interest, The effects of separation or removal of the neural tube-notochord complex on subsequent muscle formation in the chick embryo was assessed using a monoclonal antibody specific for muscle cells. Ablation of these axial structures resulted in the degeneration of newly formed somites, due to cell death, but limb muscle nevertheless formed in these embryos. Differentiation of somites to give axial muscle required a period of contact with these axial structures and this effect was reproduced with cultured somites.
-
(1992)
Development
, vol.115
, pp. 657-672
-
-
Rong1
Teillet2
Ziller3
Le Douarin4
-
4
-
-
0023228987
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Autonomy of Differentiation in Avian Brachial Somites and the Influence of Adjacent Tissues
-
(1987)
Development
, vol.100
, pp. 449-462
-
-
Kenny-Mobbs1
Thorogood2
-
6
-
-
0025120750
-
MyoD Family: a Paradigm for Development?
-
(1990)
Genes Dev
, vol.4
, pp. 1454-1461
-
-
Olson1
-
9
-
-
0026540563
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Temporal and Quantitative Analysis of Myogenic Regulatory and Growth Factor Gene Expression in the Developing Mouse Embryo
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(1992)
Dev Biol
, vol.151
, pp. 137-144
-
-
Hannon1
Smith2
Bales3
Santerre4
-
10
-
-
0026563775
-
Sequential Activation of Three Myogenic Regulatory Genes during Somite Morphogenesis in Quail Embryos
-
⊎⊎]).
-
(1992)
Dev Biol
, vol.151
, pp. 67-79
-
-
Pownall1
Emerson2
-
12
-
-
0026320442
-
Transient Expression of XMyoD in Non-somitic Mesoderm of Xenopus gastrulae
-
of special interest, Expression of XMyoD was detected by whole-mount in situ hybridization throughout the mesoderm of the early Xenopus gastrula embryo. Transcripts were also detected by northern blot analysis in ultra violet light-treated embryos that produce no muscle tissue and in cultured explants that form ventral mesoderm.
-
(1991)
Development
, vol.113
, pp. 1387-1393
-
-
Frank1
Harland2
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13
-
-
0026585332
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Expression of XMyoD Protein in Early Xenopus laevis Embryos
-
of special interest, A detailed study of XMyoD protein distribution in the Xenopus embryo using a monoclonal antibody. This gave better resolution than comparable studies of the mRNA and confirmed that XMyoD protein was present in all but the most dorsal cells of the newly formed mesoderm. Expression was localized to the cell nuclei and was later restricted to premyotomal and myotomal cells. The protein was apparently present in every cell of the myotome.
-
(1992)
Development
, vol.114
, pp. 31-38
-
-
Hopwood1
Pluck2
Gurdon3
Dilworth4
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14
-
-
0025971760
-
Xenopus Myf-5 Marks Early Muscle Cells and can Activate Muscle Genes Ectopically in Early Embryos
-
(1991)
Development
, vol.111
, pp. 551-560
-
-
Hopwood1
Pluck2
Gurdon3
-
15
-
-
0026860130
-
Expression of the Myogenic Gene MRF4 during Xenopus Development
-
(1992)
Dev Biol
, vol.151
, pp. 319-332
-
-
Jennings1
-
16
-
-
0026579129
-
MyoD, myogenin independent differentiation of primordial myoblasts in mouse somites
-
of special interest, The presence of MyoD, myogenin and myosin heavy-chain proteins was compared in cultured foetal mouse myoblasts. Late somites and limb buds gave rise to cells that expressed the myogenic factors before differentiation; a second population from early somites differentiated in culture without expressing either myogenic factor. These might constitute the migratory limb muscle precursors because they were also detected in cultures from limb buds. No antibody was available to identify Myf-5 protein.
-
(1992)
The Journal of Cell Biology
, vol.116
, pp. 1243-1255
-
-
Cuselia-De Angelis1
Lyons2
Sonnino3
De Angeles4
Vivarelli5
Farmer6
Wright7
Molinaro8
Bouche9
Buckingham10
Cossu11
-
17
-
-
0025046105
-
Activation of Muscle Genes without Myogenesis by Ectopic Expression of MyoD in Frog Embryo Cells
-
(1990)
Nature
, vol.347
, pp. 197-200
-
-
Hopwood1
Gurdon2
-
18
-
-
0026723718
-
Inhibition of Muscle Differentiation by the Adenovirus E1a Protein: Repression of the Transcriptional Activating Function of the HLH Protein Myf-5
-
of special interest, Expression of adenovirus E1A protein in rat L6 muscle cells blocks the activity of Myf-5 without affecting expression of the myf-5 gene or DNA-binding ability of the Myf-5 protein. In contrast, myogenin expression is blocked, suggesting that this factor lies downstream of myf-5 in the regulatory hierarchy.
-
(1992)
Genes Dev
, vol.6
, pp. 888-902
-
-
Braun1
Bober2
Arnold3
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20
-
-
0025869184
-
Differential Transactivation of a Muscle-specific Enhancer by Myogenic Helix-Loop-Helix Proteins is Separable from DNA Binding
-
(1991)
J Biol Chem
, vol.266
, pp. 2878-2882
-
-
Chakraborty1
Brennan2
Olson3
-
21
-
-
0026647972
-
Expression of MRF4, a Myogenic Helix-Loop-Helix Protein, Produces Multiple Changes in the Myogenic Program of BC3H-1 Cells
-
(1992)
Mol Cell Biol
, vol.12
, pp. 2484-2492
-
-
Block1
Miller2
-
22
-
-
0026440992
-
Inactivation of myoD in Mice Leads to Up-regulation of the Myogenic HLH Gene myf-5 and Results in Apparently Normal Muscle Development
-
of outstanding interest, Homologous recombination in ES cells was used to construct transgenic mice lacking a functional myoD gene. These mice show no apparent abnormalities in muscle differentiation, suggesting that the gene is functionally redundant. myf-5 RNA is elevated in the muscles of the mice, indicating that the Myf-5 protein might be substituting for MyoD.
-
(1992)
Cell
, vol.71
, pp. 383-390
-
-
Rudnicki1
Braun2
Hinuma3
Jaenisch4
-
23
-
-
0026437438
-
Targeted Inactivation of the Muscle Regulatory Gene myf-5 Results in Abnormal Rib Development and Perinatal Death
-
of outstanding interest, myf-5 is the first myogenic gene to be activated during somitogenesis in the mouse. Transgenic embryos lacking a functional myf-5 gene show a considerable delay in the first appearance of myotomal cells, but subsequent muscle differentiation is apparently normal. Interestingly, the new-born mice die at birth because they lack a normal rib cage and cannot breathe. This suggests that the myf-5 mutation affects normal differentiation of sclerotomal cells.
-
(1992)
Cell
, vol.71
, pp. 369-382
-
-
Braun1
Rudnicki2
Arnold3
Jaenisch4
-
24
-
-
0026473633
-
Developmental Regulation of Sarcomeric Gene Expression
-
(1992)
Curr Top Dev Biol
, vol.26
, pp. 145-168
-
-
Ordahl1
-
25
-
-
0025994343
-
Muscle-specific Transcriptional Activation by MyoD
-
of special interest, The transcriptional-activation domain of MyoD was mapped to the amino-terminal portion of the protein as assessed by domain swap experiments. Systematic mutagenesis of the basic region identified an Ala-Thr pair of residues to be critical for MyoD function. The authors suggest that another factor that recognizes the basic region is required for MyoD function.
-
(1991)
Genes Dev
, vol.5
, pp. 1377-1386
-
-
Weintraub1
Dwarki2
Verma3
Davis4
Hollenberg5
Snider6
Lassar7
Tapscott8
-
26
-
-
0026580086
-
The Basic Region of Myogenin Cooperates with Two Transcription Activation Domains to Induce Muscle-specific Transcription
-
of special interest, Domain-swap experiments demonstrated that the transcriptional activation functions of myogenin map to both amino- and carboxyl-terminal domains of the protein. Activation of reporter genes via E-box sites requires the myogenin basic region, even with chimeric VP16-myogenin proteins, indicating that the basic region also participates in transcriptional activation function.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 266-275
-
-
Schwarz1
Chakraborty2
Martin3
Zhou4
Olson5
-
27
-
-
0026529505
-
Co-operativity of Functional Domains in the Muscle-specific Transcription Factor myf-5
-
(1992)
EMBO J
, vol.11
, pp. 1843-1855
-
-
Winter1
Braun2
Arnold3
-
29
-
-
0026738862
-
Identification of MRF4, Myogenin, and E12 Oligomer Complexes by Chemical Cross-linking and Two-dimensional Gel Electrophoresis
-
(1992)
J Biol Chem
, vol.267
, pp. 4773-4780
-
-
Lin1
Konieczny2
-
30
-
-
0025808242
-
Functional Activity of Myogenic HLH Proteins Requires Hetero-oligomerization with E12/E47-like Proteins in vivo
-
of outstanding interest, Comprehensive demonstration that E12/E47 proteins associate in vivo with MyoD and myogenin. Myogenic conversion of 10T1/2 cells by MyoD results in activation of the muscle-specific regulators, MCAT and MEF-2. The authors discuss the possibility that competition for E-proreins provides a mechanism for ensuring that different HLH-dependent developmental decisions are mutually exclusive.
-
(1991)
Cell
, vol.66
, pp. 305-315
-
-
Lassar1
Davis2
Wright3
Kadesch4
Murre5
Voronova6
Baltimore7
Weintraub8
-
31
-
-
0025217856
-
The MyoD DNA Binding Domain Contains a Recognition Code for Muscle-specific Gene Activation
-
(1990)
Cell
, vol.60
, pp. 733-746
-
-
Davis1
Cheng2
Lassar3
Weintraub4
-
34
-
-
0026766680
-
Acquisition of Myogenic Specificity by Replacement of Three Amino Acid Residues from MyoD, into E12
-
of special interest, An E12 protein containing only two replacements (Ala-Thr) in the basic region and a third replacement (Lys) at the junction with helix 1 acquired the ability to convert 10T1/2 fibroblasts into muscle cells.
-
(1992)
Science
, vol.256
, pp. 1027-1030
-
-
Davis1
Weintraub2
-
39
-
-
0026513957
-
Functional Antagonism Between c-Jun and MyoD Proteins: a Direct Physical Association
-
of outstanding interest, Transactivation of the MyoD promoter, the MCK enhancer and an E-box driven reporter by MyoD were all blocked by cotransfection with a jun expression vector; in reciprocal experiments, MyoD suppressed transactivation of a reporter containing an AP-1 site by Jun. Direct interaction of the Jun and MyoD was demonstrated both in vivo and in vitro, requiring the leucine zipper domain of Jun and the HLH region of MyoD.
-
(1992)
Cell
, vol.68
, pp. 507-519
-
-
Bengal1
Ransone2
Scharfmann3
Dwarki4
Tapscott5
Weintraub6
Verma7
-
40
-
-
0026043437
-
v-jun Oncogene Prevents Terminal Differentiation and Suppresses Muscle-specific Gene Expression in ASVD17D-infected Muscle Cells
-
(1991)
Oncogene
, vol.6
, pp. 1767-1773
-
-
Grossi1
Calconi2
Tato3
-
41
-
-
0026606084
-
Fos and Jun Repress Transcriptional Activation by Myogenin and MyoD: the Amino Terminus of Jun Can Mediate Repression
-
⊎⊎]).
-
(1992)
Genes Dev
, vol.6
, pp. 676-689
-
-
Li1
Chambard2
Karin3
Olson4
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