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Volumn 2, Issue 4, 1992, Pages 324-329

Mitochondrial DNA deletions in human brain: Regional variability and increase with advanced age

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

EID: 0027017232     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1292-324     Document Type: Article
Times cited : (771)

References (40)
  • 1
    • 0024541837 scopus 로고
    • Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases
    • Linnane, A. W., Marzuki, S. Ozawa, T. & Tanaka, M. Mitochondrial DNA mutations as an important contributor to ageing and degenerative diseases. Lancet 3, 642-645 (1989).
    • (1989) Lancet , vol.3 , pp. 642-645
    • Linnane, A.W.1    Marzuki, S.2    Ozawa, T.3    Tanaka, M.4
  • 2
    • 0026587335 scopus 로고
    • Mitochondrial genetics: A paradigm for ageing and degenerative diseases?
    • Wallace, D. C. Mitochondrial genetics: A paradigm for ageing and degenerative diseases? Science 256, 628-632 (1992).
    • (1992) Science , vol.256 , pp. 628-632
    • Wallace, D.C.1
  • 3
    • 0026624980 scopus 로고
    • Diseases of the mitochondrial DNA
    • Wallace, D. C. Diseases of the mitochondrial DNA. Ann. Rev. Biochem. 61, 1175-1212(1992).
    • (1992) Ann. Rev. Biochem , vol.61 , pp. 1175-1212
    • Wallace, D.C.1
  • 4
    • 0024366601 scopus 로고
    • Cytochrome-c-oxidase deficient cardiomyocytes in the human heart
    • Muller-Hocker, J. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart. Am. J. Pathol. 134, 1167-1173 (1989).
    • (1989) Am. J. Pathol , vol.134 , pp. 1167-1173
    • Muller-Hocker, J.1
  • 5
    • 0025673968 scopus 로고
    • Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration
    • Muller-Hocker, J. Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration. J. neurol. Sci. 100, 14-21 (1990).
    • (1990) J. neurol. Sci , vol.100 , pp. 14-21
    • Muller-Hocker, J.1
  • 6
    • 0024580556 scopus 로고
    • Decline in skelet al muscle mitochondrial respiratory chain function: Possible factor in aging
    • Trounce, I., Byrne, E. & Marzuki, S. Decline in skelet al muscle mitochondrial respiratory chain function: Possible factor in aging. Lancet 1, 637-639 (1989).
    • (1989) Lancet , vol.1 , pp. 637-639
    • Trounce, I.1    Byrne, E.2    Marzuki, S.3
  • 8
    • 0023944266 scopus 로고
    • Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging
    • Piko, L, Hougham, A. J. & Bulpitt, K. J. Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging. Mech. ageing Devi. 43, 279-293 (1988).
    • (1988) Mech. ageing Devi , vol.43 , pp. 279-293
    • Piko, L.1    Hougham, A.J.2    Bulpitt, K.J.3
  • 9
    • 0026340875 scopus 로고
    • Deleted mitochondrial DNA in the skelet al muscle of aged individuals
    • Katayama, M. et. al. Deleted mitochondrial DNA in the skelet al muscle of aged individuals. Biochem. Int. 25, 47-56 (1991).
    • (1991) Biochem. Int , vol.25 , pp. 47-56
    • Katayama, M.1
  • 10
    • 0025741445 scopus 로고
    • Ageing-associated 5 kb deletion in human liver mitochondrial DNA
    • Yen, T. C., Su, J. H., King, K. L & Wei, Y. H. Ageing-associated 5 kb deletion in human liver mitochondrial DNA. Biochem. Biophys. Res. Commun. 178, 124-131 (1991).
    • (1991) Biochem. Biophys. Res. Commun , vol.178 , pp. 124-131
    • Yen, T.C.1    Su, J.H.2    King, K.L.3    Wei, Y.H.4
  • 11
    • 0026532722 scopus 로고
    • Multiple mitochondrial DNA deletions in an elderly human individual
    • Zhang, C., Baumer, A., Maxwell, R. J., Linnane, A. W. & Nagley, P. Multiple mitochondrial DNA deletions in an elderly human individual. FEBS Lett. 297, 34-38(1992).
    • (1992) FEBS Lett , vol.297 , pp. 34-38
    • Zhang, C.1    Baumer, A.2    Maxwell, R.J.3    Linnane, A.W.4    Nagley, P.5
  • 12
    • 0025674177 scopus 로고
    • Detection of a specific mitochondrial DNA deletion in tissues of older humans
    • Cortopassi, G. A & Amheim, N. Detection of a specific mitochondrial DNA deletion in tissues of older humans. Nucleic Acid Res. 18, 6927-6933 (1990).
    • (1990) Nucleic Acid Res , vol.18 , pp. 6927-6933
    • Cortopassi, G.A.1    Amheim, N.2
  • 13
    • 0026074885 scopus 로고
    • Hypoxemia is associated wrth mitochondrial DNA damage and gene induction: Implications for cardiac disease
    • Corral-Debrinski, M. et. al. Hypoxemia is associated wrth mitochondrial DNA damage and gene induction: Implications for cardiac disease. JAMA 266, 1812-1816(1991).
    • (1991) JAMA , vol.266 , pp. 1812-1816
    • Corral-Debrinski, M.1
  • 14
    • 0026671245 scopus 로고
    • Association of mitochondrial DNA damage with ageing and coronary atherosclerotic disease
    • Corral-Debrinski, M., Shoffner, J. M., Lott, M. T. & Wallace, D. C. Association of mitochondrial DNA damage with ageing and coronary atherosclerotic disease. Mutat. Res. 275, 169-180(1992).
    • (1992) Mutat. Res , vol.275 , pp. 169-180
    • Corral-Debrinski, M.1    Shoffner, J.M.2    Lott, M.T.3    Wallace, D.C.4
  • 15
    • 0025758425 scopus 로고
    • Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia
    • Hattori, K. et. al. Age-dependent increase in deleted mitochondrial DNA in the human heart: Possible contributory factor to presbycardia. Am. Heart J. 121, 1735-1742 (1991).
    • (1991) Am. Heart J , vol.121 , pp. 1735-1742
    • Hattori, K.1
  • 17
    • 0025864512 scopus 로고
    • An integrated theory of ageing as the result of mitochondrial DNA mutation in differentiated cells
    • Miquel, J. An integrated theory of ageing as the result of mitochondrial DNA mutation in differentiated cells. Arch. Gerontol. Gerìatr. 12, 99-117 (1991).
    • (1991) Arch. Gerontol. Gerìatr , vol.12 , pp. 99-117
    • Miquel, J.1
  • 18
    • 0023811053 scopus 로고
    • Normal oxidative damage to mitochondrial and nuclear DNA is extensive
    • Richter, C., Park, J. W. & Ames, B. N. Normal oxidative damage to mitochondrial and nuclear DNA is extensive. Proc. natn. Acad. Sci. U. S. A. 85, 6465-6467 (1988).
    • (1988) Proc. natn. Acad. Sci. U.S.A , vol.85 , pp. 6465-6467
    • Richter, C.1    Park, J.W.2    Ames, B.N.3
  • 19
    • 0018667684 scopus 로고
    • Fate during cell growth of yeast mitochondria and nuclear DNA after photolytic attachment of the monoazide analog of ethidium
    • Fukunaga M. & Yielding K. L. Fate during cell growth of yeast mitochondria and nuclear DNA after photolytic attachment of the monoazide analog of ethidium. Biochem. Biophys. Res. Commun. 90, 582-586 (1979).
    • (1979) Biochem. Biophys. Res. Commun , vol.90 , pp. 582-586
    • Fukunaga, M.1    Yielding, K.L.2
  • 20
    • 0025309791 scopus 로고
    • Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and ageing ?
    • Bandy, B. & Davison, A. J. Mitochondrial mutations may increase oxidative stress: Implications for carcinogenesis and ageing ? Mutat. Res. 8, 523-539 (1990).
    • (1990) Mutat. Res , vol.8 , pp. 523-539
    • Bandy, B.1    Davison, A.J.2
  • 21
    • 0023831219 scopus 로고
    • Free radicals and myocardial ischemia: Overview and outlook
    • McCord, J. M. Free radicals and myocardial ischemia: overview and outlook. Free Rad. Biol. Med. 4, 9-14 (1988).
    • (1988) Free Rad. Biol. Med , vol.4 , pp. 9-14
    • McCord, J.M.1
  • 22
  • 23
    • 0023856245 scopus 로고
    • Imaging of the ageing brain Part!. Normal findings
    • Drayer, B. P. Imaging of the ageing brain Part!. Normal findings. Radiology 166, 785-796 (1988).
    • (1988) Radiology , vol.166 , pp. 785-796
    • Drayer, B.P.1
  • 24
    • 0025797670 scopus 로고
    • Cerebral blood flow and metabolism in ageing and dementia
    • Goldstein, S. & Relvich, M. Cerebral blood flow and metabolism in ageing and dementia. Clin. Neuropharm. 14, S34-S44 (1991).
    • (1991) Clin. Neuropharm , vol.14 , pp. S34-S44
    • Goldstein, S.1    Relvich, M.2
  • 25
    • 0242517083 scopus 로고
    • Changes in local cerebral glucose metabolism with normal ageing: The effect of cardiovascular and systemic health factors
    • Chawluk, J. B. Alavi, A. & Jamieson, D. G. Changes in local cerebral glucose metabolism with normal ageing: the effect of cardiovascular and systemic health factors. J. Cereb. Blood Flow Metab. 7, S411 (1987).
    • (1987) J. Cereb. Blood Flow Metab , vol.7 , pp. S411
    • Chawluk, J.B.1    Alavi, A.2    Jamieson, D.G.3
  • 26
    • 0023268562 scopus 로고
    • Neuropathological and clinical features of Parkinson’s disease in Alzheimer’s diseases patients
    • Ditter, S. M. & Mirra, S. S. Neuropathological and clinical features of Parkinson’s disease in Alzheimer’s diseases patients. Neurology 37, 754-760(1987).
    • (1987) Neurology , vol.37 , pp. 754-760
    • Ditter, S.M.1    Mirra, S.S.2
  • 27
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part H. Standardization of the neuropathological assessment of Alzheimer’s disease
    • Mirra, S. S. et al. The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). Part H. Standardization of the neuropathological assessment of Alzheimer’s disease. Neurology 41, 479-486 (1991).
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1
  • 29
    • 0024317560 scopus 로고
    • Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome isassociated with a mtDNA deletion: Aslip-replication model and metabolic therapy
    • Shoffn6r, J. M. et. al. Spontaneous Kearns-Sayre/chronic external ophthalmoplegia plus syndrome isassociated with a mtDNA deletion: Aslip-replication model and metabolic therapy. Proc. natn. Acad. Sci. U. S. A. 88, 7952-7956 (1989).
    • (1989) Proc. natn. Acad. Sci. U.S.A , vol.88 , pp. 7952-7956
    • Shoffncr, J.M.1
  • 30
    • 0025004427 scopus 로고
    • Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy
    • Ozawa, T. et al. Multiple mitochondrial DNA deletions exist in cardiomyocytes of patients with hypertrophic or dilated cardiomyopathy. Biochem. Biophys. Res. Commun. 170, 830-836 (1990).
    • (1990) Biochem. Biophys. Res. Commun , vol.170 , pp. 830-836
    • Ozawa, T.1
  • 32
    • 0025766187 scopus 로고
    • & McManus D.Q. The neurology of ageing: Normal versus pathological changes
    • Morris, J. C. & McManus D. Q. The neurology of ageing: Normal versus pathological changes. Geriatrics 48, 47-54 (1991).
    • (1991) Geriatrics , vol.48 , pp. 47-54
    • Morris, J.C.1
  • 33
    • 0024462967 scopus 로고
    • Endogenous DNA damage as related to cancer and aging
    • Ames, B. N. Endogenous DNA damage as related to cancer and aging. Mutat. Res. 214, 41-46 (1989).
    • (1989) Mutat. Res , vol.214 , pp. 41-46
    • Ames, B.N.1
  • 35
    • 0021358681 scopus 로고
    • Positron emission tomographic studies in ageing and cerebrovascular disease at Hammersmith Hospital
    • Frackowiak, R. S. J., Wise, R. J. S. Gibbs, J. M. & Jones, T. Positron emission tomographic studies in ageing and cerebrovascular disease at Hammersmith Hospital. Ann. Neurol. 15, S112-S118 (1984).
    • (1984) Ann. Neurol , vol.15 , pp. S112-S118
    • Frackowiak, R.S.J.1    Wise, R.J.S.2    Gibbs, J.M.3    Jones, T.4
  • 36
    • 84970050103 scopus 로고
    • Reduction in regional cerebral metabolic rate of oxygen during human aging
    • Yamaguchi, T., Kanno, I., & Vermura, K. Reduction in regional cerebral metabolic rate of oxygen during human aging. Stroke 171, 220-228 (1986).
    • (1986) Stroke , vol.171 , pp. 220-228
    • Yamaguchi, T.1    Kanno, I.2    Vermura, K.3
  • 37
    • 0023712050 scopus 로고
    • Sensitivity of cerebral glucose metabolism, to age, gender, brain volume, brain atrophy and cerebrovascular risk factors
    • Yoshii, F. et. al. Sensitivity of cerebral glucose metabolism, to age, gender, brain volume, brain atrophy and cerebrovascular risk factors. J. Cereb. Blood Flow Met. 8, 654-661 (1988).
    • (1988) J. Cereb. Blood Flow Met , vol.8 , pp. 654-661
    • Yoshii, F.1
  • 38
    • 0026408619 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer’s disease
    • Parker, W. D. Cytochrome oxidase deficiency in Alzheimer’s disease, Annal. N. Y. Acad. Sci. 840, 59-64 (1992).
    • (1992) Annal. N.Y. Acad. Sci , vol.840 , pp. 59-64
    • Parker, W.D.1
  • 39
    • 0024317904 scopus 로고
    • Prevalence of Alzheimer’s disease in a community population of older persons. Higher than previously reported
    • Evans, D. A. et. al. Prevalence of Alzheimer’s disease in a community population of older persons. Higher than previously reported. JAMA 282, 2551-2556 (1989).
    • (1989) JAMA , vol.282 , pp. 2551-2556
    • Evans, D.A.1


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