메뉴 건너뛰기




Volumn 3, Issue 5, 1992, Pages 351-362

Conjugates of Anticancer Agents and Polymers: Advantages of Macromolecular Therapeutics in Vivo

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; DRUG CARRIER; IMMUNOTOXIN; POLYMER;

EID: 0026926609     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc00017a001     Document Type: Article
Times cited : (564)

References (111)
  • 1
    • 0021211007 scopus 로고
    • Tailor-making of protein drugs by polymer conjugation for tumor targeting. A brief review on smancs
    • Maeda, H. Matsumoto, T. Konno, T., Iwai, K. and Ueda, M. (1984) Tailor-making of protein drugs by polymer conjugation for tumor targeting. A brief review on smancs. J. Protein Chem. 3, 181-193.
    • (1984) J. Protein Chem. , vol.3 , pp. 181-193
    • Maeda, H.1    Matsumoto, T.2    Konno, T.3    Iwai, K.4    Ueda, M.5
  • 2
    • 0026118760 scopus 로고
    • SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy
    • Maeda, H. (1991) SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy. Adv. Drug Delivery Rev. 6, 181-202.
    • (1991) Adv. Drug Delivery Rev. , vol.6 , pp. 181-202
    • Maeda, H.1
  • 3
    • 0024839642 scopus 로고
    • Tumoritropic and lymphotropic principles of macromolecular drugs
    • Maeda, H., and Matsumura, Y. (1989) Tumoritropic and lymphotropic principles of macromolecular drugs. Crit. Rev. Ther. Drug Carrier Syst. 6, 193-210.
    • (1989) Crit. Rev. Ther. Drug Carrier Syst. , vol.6 , pp. 193-210
    • Maeda, H.1    Matsumura, Y.2
  • 4
    • 0026694788 scopus 로고
    • Passive tumour-targeting of soluble macromolecules and drug conjugates
    • Seymour, L. (1992) Passive tumour-targeting of soluble macromolecules and drug conjugates. Crit. Rev. Ther. Drug Carrier Syst. 9, 135-187.
    • (1992) Crit. Rev. Ther. Drug Carrier Syst. , vol.9 , pp. 135-187
    • Seymour, L.1
  • 5
    • 0026757191 scopus 로고
    • Drug-polymer conjugates: potential for improved chemotherapy
    • in press).
    • Duncan, R. (1992) Drug-polymer conjugates: potential for improved chemotherapy. Anti-Cancer Drugs (in press).
    • (1992) Anti-Cancer Drugs
    • Duncan, R.1
  • 6
    • 0001614302 scopus 로고
    • PVP-iodine: history, toxicity and therapeutic uses
    • Shelanski, H. A., and Shelanski, M. V. (1956) PVP-iodine: history, toxicity and therapeutic uses. J. Intern. Coll. Surgeons 25, 727-734.
    • (1956) J. Intern. Coll. Surgeons , vol.25 , pp. 727-734
    • Shelanski, H.A.1    Shelanski, M.V.2
  • 7
    • 0002079949 scopus 로고
    • Disposition and tumor localization of mitomycin C-Dextran conjugates in mice
    • Takakura, Y., Takagi, A. Hashida, M., and Sezaki, H. (1987) Disposition and tumor localization of mitomycin C-Dextran conjugates in mice. Pharm. Res. 4, 293-300.
    • (1987) Pharm. Res. , vol.4 , pp. 293-300
    • Takakura, Y.1    Takagi, A.2    Hashida, M.3    Sezaki, H.4
  • 8
    • 0013391194 scopus 로고
    • Cancer selective macromolecular therapeusis: tailoring of an antitumor protein drug
    • R. E. Feeny and J. R. Whitaker, Eds. Marcel Dekker Inc., New York.
    • Maeda, H., Matsumoto, Y. Oda, T., and Sasamoto, K. (1986) Cancer selective macromolecular therapeusis: tailoring of an antitumor protein drug. Protein Tailoring for Food and Medical Uses (R. E. Feeny and J. R. Whitaker, Eds.), 353-382, Marcel Dekker Inc., New York.
    • (1986) Protein Tailoring for Food and Medical Uses , pp. 353-382
    • Maeda, H.1    Matsumoto, Y.2    Oda, T.3    Sasamoto, K.4
  • 9
    • 0023779745 scopus 로고
    • Chemical modification of superoxide dismutase. Extension of plasma half-life of the enzyme through its reversible binding to the circulating albumin
    • Ogino, T., Inoue, M. Ando, Y. Arai, M. Maeda, H., and Morino, Y. (1988) Chemical modification of superoxide dismutase. Extension of plasma half-life of the enzyme through its reversible binding to the circulating albumin. Int. J. Pept. Protein Res. 32, 153-159.
    • (1988) Int. J. Pept. Protein Res. , vol.32 , pp. 153-159
    • Ogino, T.1    Inoue, M.2    Ando, Y.3    Arai, M.4    Maeda, H.5    Morino, Y.6
  • 10
    • 0024235612 scopus 로고
    • Protein binding of macromolecular anticancer agent SMANCS: Characterization of poly(styrene-comaleic acid) derivatives as an albumin binding ligand
    • Kobayashi, A., Oda, T., and Maeda, H. (1988) Protein binding of macromolecular anticancer agent SMANCS: Characterization of poly(styrene-comaleic acid) derivatives as an albumin binding ligand. J. Bioact. Compat. Polym. 3, 319-328.
    • (1988) J. Bioact. Compat. Polym. , vol.3 , pp. 319-328
    • Kobayashi, A.1    Oda, T.2    Maeda, H.3
  • 11
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and antitumor agent smancs
    • Matsumura, Y_, and Maeda, H. (1986) A new concept for macromolecular therapeutics in cancer chemotherapy: Mechanism of tumoritropic accumulation of proteins and antitumor agent smancs. Cancer Res. 46, 6387-6392.
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 12
    • 0023450012 scopus 로고    scopus 로고
    • Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal and intravenous administration to rats
    • Seymour, L. W., Duncan, R., Strohalm, J., and Kopecek, J. Effect of molecular weight (Mw) of N-(2-hydroxypropyl)methacrylamide copolymers on body distribution and rate of excretion after subcutaneous, intraperitoneal and intravenous administration to rats. J. Biomed. Mater. Res. 21, 1341-1358.
    • J. Biomed. Mater. Res. , vol.21 , pp. 1341-1358
    • Seymour, L.W.1    Duncan, R.2    Strohalm, J.3    Kopecek, J.4
  • 13
    • 0023034241 scopus 로고
    • Enhancement of vascular permeability upon serratial infection: Activation of Hageman factor-kallikrein-kinin cascade
    • L. B. Greenbaum and H. S. Margolius, Ed. AEMB 198B), Plenum Press, New York
    • Matsumoto, M.H.K. Yamamoto, T., Kamata, R., and Maeda, H. (1986) Enhancement of vascular permeability upon serratial infection: Activation of Hageman factor-kallikrein-kinin cascade. Kinin IV, partB (L. B. Greenbaum and H. S. Margolius, Ed.) pp 71-78 (AEMB 198B), Plenum Press, New York.
    • (1986) Kinin IV, partB , pp. 71-78
    • Matsumoto, M.H.K.1    Yamamoto, T.2    Kamata, R.3    Maeda, H.4
  • 14
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascitic fluid
    • Senger, D. R., Galli, S. J., Dvorak, A. M., Perruzzi, C. A. Harrey, V. S., and Dvorak, H. F. (1983) Tumor cells secrete a vascular permeability factor that promotes accumulation of ascitic fluid. Science 219, 983-985.
    • (1983) Science , vol.219 , pp. 983-985
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3    Perruzzi, C.A.4    Harrey, V.S.5    Dvorak, H.F.6
  • 15
    • 0023788067 scopus 로고
    • Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules
    • Dvorak, H. F., Nagy, J. A., Dvorak, J. T., and Dvorak, A. M. (1988) Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules. Am. J. Pathol. 133, 95-109.
    • (1988) Am. J. Pathol. , vol.133 , pp. 95-109
    • Dvorak, H.F.1    Nagy, J.A.2    Dvorak, J.T.3    Dvorak, A.M.4
  • 16
    • 0024818355 scopus 로고
    • Vascular endothelial growth factor is a secreted angiogenic mitogen
    • Leung, D. W., Cachianes, G., Kuang, W.-J. Goeddel, D. V., and Ferrara, N. (1989) Vascular endothelial growth factor is a secreted angiogenic mitogen. Science 246, 1306-1309.
    • (1989) Science , vol.246 , pp. 1306-1309
    • Leung, D.W.1    Cachianes, G.2    Kuang, W.-J.3    Goeddel, D.V.4    Ferrara, N.5
  • 17
  • 18
    • 0023039225 scopus 로고    scopus 로고
    • A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cells
    • Senger, D. R., Perruzzi, C. A. Feder, J. and Dvorak, H.-F., A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cells. Cancer Res. 46, 5629-5632.
    • Cancer Res. , vol.46 , pp. 5629-5632
    • Senger, D.R.1    Perruzzi, C.A.2    Feder, J.3    Dvorak, H.-F.4
  • 19
    • 0025194878 scopus 로고
    • Purification and NH2-terminal amino acid sequences of guinea pig tumor-secreted vascular permeability factor
    • Senger, D. R. Connolly, D. T. Van de Water, L. Feder, J., and Dvorak, H. F. (1990) Purification and NH2-terminal amino acid sequences of guinea pig tumor-secreted vascular permeability factor. Cancer Res. 50, 1774-1778.
    • (1990) Cancer Res. , vol.50 , pp. 1774-1778
    • Senger, D.R.1    Connolly, D.T.2    Van de Water, L.3    Feder, J.4    Dvorak, H.F.5
  • 20
    • 0026089929 scopus 로고
    • Tumor-secreted vascular permeability factor increases cytosolic calcium and von Willebrand factor release in human endothelial cells
    • Brock, T. A., Dvorak, H. F. and Senger, D. (1991) Tumor-secreted vascular permeability factor increases cytosolic calcium and von Willebrand factor release in human endothelial cells. Am. J. Pathol. 138, 213-221.
    • (1991) Am. J. Pathol. , vol.138 , pp. 213-221
    • Brock, T.A.1    Dvorak, H.F.2    Senger, D.3
  • 21
    • 0026092346 scopus 로고
    • Specific binding of vascular permeability factor to endothelial cells
    • Olander, J. V., Connolly, D. T., and DeLarco, J. E. (1991) Specific binding of vascular permeability factor to endothelial cells. Biochem. Biophys. Res. Commun. 175, 68-76.
    • (1991) Biochem. Biophys. Res. Commun. , vol.175 , pp. 68-76
    • Olander, J.V.1    Connolly, D.T.2    DeLarco, J.E.3
  • 22
    • 0023821387 scopus 로고
    • Purifìcation and identification of [hydroxyprolyl3] -bradykinin in ascitic fluid from a patient with gastric cancer
    • Maeda, H., Matsumura, Y., and Kato, H. (1988) Purifìcation and identification of [hydroxyprolyl3] -bradykinin in ascitic fluid from a patient with gastric cancer. J. Biol. Chem. 263, 16051-16056.
    • (1988) J. Biol. Chem. , vol.263 , pp. 16051-16056
    • Maeda, H.1    Matsumura, Y.2    Kato, H.3
  • 23
    • 0024151625 scopus 로고
    • Involvement of kinin-generating cascade in enhanced vascular permeability in tumor tissue
    • Matsumura, Y. Kimura, M. Yamamoto, T. and Maeda, H. (1988) Involvement of kinin-generating cascade in enhanced vascular permeability in tumor tissue. Jpn. J. Cancer Res. 79, 1327-1334.
    • (1988) Jpn. J. Cancer Res. , vol.79 , pp. 1327-1334
    • Matsumura, Y.1    Kimura, M.2    Yamamoto, T.3    Maeda, H.4
  • 25
    • 0025254538 scopus 로고
    • Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: Analysis by HPLC
    • Matsumura, Y. Maeda, H. and Kato, H. (1990) Degradation pathway of kinins in tumor ascites and inhibition by kininase inhibitors: Analysis by HPLC. Agents Actions 29, 172-180.
    • (1990) Agents Actions , vol.29 , pp. 172-180
    • Matsumura, Y.1    Maeda, H.2    Kato, H.3
  • 26
    • 0021963073 scopus 로고
    • Increased vascular permeability: A major cause of hypoalbuminemia in disease and injury
    • McA.
    • Fleck, A. Hawker, F. Wallace, P. I. Raines, G., Trotter, J. Ledingham, I. McA., and Caiman, K. C. (1985) Increased vascular permeability: A major cause of hypoalbuminemia in disease and injury. Lancet Apr 6, 781-784.
    • (1985) Lancet Apr , vol.6 , pp. 781-784
    • Fleck, A.1    Hawker, F.2    Wallace, P.I.3    Raines, G.4    Trotter, J.5    Ledingham, I.6    Caiman, K.C.7
  • 27
    • 0023891889 scopus 로고
    • Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice
    • Ettinghausen, S. E., Puri, R. J. and Rosenberg, S. A. (1988) Increased vascular permeability in organs mediated by the systemic administration of lymphokine-activated killer cells and recombinant interleukin-2 in mice. J. Natl. Cancer Inst. 80, 177-187.
    • (1988) J. Natl. Cancer Inst. , vol.80 , pp. 177-187
    • Ettinghausen, S.E.1    Puri, R.J.2    Rosenberg, S.A.3
  • 28
    • 0021349643 scopus 로고
    • Use of oily contrast medium for selective drug targeting to tumor: Enhanced therapeutic effect and X-ray image
    • Iwai, K., Maeda, H., and Konno, T. (1984) Use of oily contrast medium for selective drug targeting to tumor: Enhanced therapeutic effect and X-ray image. Cancer Res. 44, 2114-2121.
    • (1984) Cancer Res. , vol.44 , pp. 2114-2121
    • Iwai, K.1    Maeda, H.2    Konno, T.3
  • 30
    • 0021687244 scopus 로고
    • Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium
    • Konno, T. Maeda, H. Iwai, K. Maki, S. Tashiro, S. Uchida, M., and Miyauchi, Y. (1984) Selective targeting of anticancer drug and simultaneous image enhancement in solid tumors by arterially administered lipid contrast medium. Cancer 54, 2367-2374.
    • (1984) Cancer , vol.54 , pp. 2367-2374
    • Konno, T.1    Maeda, H.2    Iwai, K.3    Maki, S.4    Tashiro, S.5    Uchida, M.6    Miyauchi, Y.7
  • 31
    • 0021968171 scopus 로고
    • Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer
    • Maki, S. Konno, T., and Maeda, H. (1985) Image enhancement in computerized tomography for sensitive diagnosis of liver cancer and semiquantitation of tumor selective drug targeting with oily contrast medium. Cancer. 56, 751-757.
    • (1985) , vol.56 , pp. 751-757
    • Maki, S.1    Konno, T.2    Maeda, H.3
  • 32
    • 0020525867 scopus 로고
    • Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: A preliminary report
    • Konno, T., Maeda, H., Tashiro, S., Maki, S. Morinaga, T., Mochinaga, M., Hiraoka, T., and Yokoyama, I. (1983) Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: A preliminary report. Eur. J. Cancer Clin. Oncol. 19, 1053-1065.
    • (1983) Eur. J. Cancer Clin. Oncol. , vol.19 , pp. 1053-1065
    • Konno, T.1    Maeda, H.2    Tashiro, S.3    Maki, S.4    Morinaga, T.5    Mochinaga, M.6    Hiraoka, T.7    Yokoyama, I.8
  • 33
    • 0002289558 scopus 로고
    • The origin of lipoprotein in lymph
    • Meyersen, H. S., Chairman C. C. Thomas, Springfield, IL.
    • Coutice, F. C. (1963) The origin of lipoprotein in lymph. Lymph and the Lymphatic System. (Meyersen, H. S., Chairman) pp 89-126, C. C. Thomas, Springfield, IL.
    • (1963) Lymph and the Lymphatic System. , pp. 89-126
    • Coutice, F.C.1
  • 34
    • 0019478990 scopus 로고
    • A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II
    • Suzuki, M., Hori, M.H.K. Abe, I., Saito, S. and Sato, H. (1981) A new approach to cancer chemotherapy: Selective enhancement of tumor blood flow with angiotensin II. J. Natl. Cancer Inst. 67, 663-669.
    • (1981) J. Natl. Cancer Inst. , vol.67 , pp. 663-669
    • Suzuki, M.1    Hori, M.H.K.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 35
    • 0021999595 scopus 로고
    • Increase in tumor vascular area due to increased blood flow by angiotensin II in rats
    • Hori, K., Suzuki, M., Abe, I., Saito, S. and Sato, H_ (1985) Increase in tumor vascular area due to increased blood flow by angiotensin II in rats. J. Natl. Cancer Inst. 74, 453-459.
    • (1985) J. Natl. Cancer Inst. , vol.74 , pp. 453-459
    • Hori, K.1    Suzuki, M.2    Abe, I.3    Saito, S.4    Sato, H.5
  • 37
    • 0014673113 scopus 로고
    • Antigenicity: Some molecular aspects
    • Sela, M. (1969) Antigenicity: Some molecular aspects. Science 166, 1365-1374.
    • (1969) Science , vol.166 , pp. 1365-1374
    • Sela, M.1
  • 38
    • 0000529593 scopus 로고
    • Molecular structural effects produced in proteins by reaction with succinic anhydride
    • Habeeb, A. F. S. A. Cassidy, H. G. and Singer, S. F. (1958) Molecular structural effects produced in proteins by reaction with succinic anhydride, Biochim. Biophys. Acta 29, 587-593.
    • (1958) Biochim. Biophys. Acta , vol.29 , pp. 587-593
    • Habeeb, A.F.S.A.1    Cassidy, H.G.2    Singer, S.F.3
  • 39
    • 0013844043 scopus 로고
    • Role of the carrier in development of delayed sensitivity to the azophenyl-azonate group
    • Jones, V. E. and Leskowitz, S. (1965) Role of the carrier in development of delayed sensitivity to the azophenyl-azonate group. Nature 207, 596-597.
    • (1965) Nature , vol.207 , pp. 596-597
    • Jones, V.E.1    Leskowitz, S.2
  • 40
    • 0022658309 scopus 로고
    • Isotope distribution and fine specificity of the antibody response or inbred mouse strain to four compounds belonging to a new group of synthetic branched polypeptide
    • Rajnavolgyi, E., Hudecz, F., Mezo, G., Szekerke, M., and Gergely, J. (1986) Isotope distribution and fine specificity of the antibody response or inbred mouse strain to four compounds belonging to a new group of synthetic branched polypeptide. Mol. Immunol. 23, 27-37.
    • (1986) Mol. Immunol. , vol.23 , pp. 27-37
    • Rajnavolgyi, E.1    Hudecz, F.2    Mezo, G.3    Szekerke, M.4    Gergely, J.5
  • 41
    • 0021676387 scopus 로고
    • The adjuvant activity of nonionic block polymer surfactants. Antibody formation and inflammation related to the structure of triblock and octablock copolymer
    • Hunter, R. L. and Bennet, B. (1984) The adjuvant activity of nonionic block polymer surfactants. Antibody formation and inflammation related to the structure of triblock and octablock copolymer. J, Immunol. 133, 3167-3175.
    • (1984) J, Immunol. , vol.133 , pp. 3167-3175
    • Hunter, R.L.1    Bennet, B.2
  • 42
    • 0019461927 scopus 로고
    • Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypoly(ethylene glycol)
    • Kamisaki, Y., Wada, H., Yagura, H., Matsushima, A., and Inada, Y. (1981) Reduction in immunogenicity and clearance rate of Escherichia coli L-asparaginase by modification with monomethoxypoly(ethylene glycol). J. Pharmacol. Exp, Ther. 216, 410-414.
    • (1981) J. Pharmacol. Exp, Ther. , vol.216 , pp. 410-414
    • Kamisaki, Y.1    Wada, H.2    Yagura, H.3    Matsushima, A.4    Inada, Y.5
  • 43
    • 0017701219 scopus 로고    scopus 로고
    • Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol
    • Abuchowski, A., Es, T.-V., Palczuk, N. C. and Davis, F. F. Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol. J. Biol. Chem. 252, 3578-3581.
    • J. Biol. Chem. , vol.252 , pp. 3578-3581
    • Abuchowski, A.1    Es, T.-V.2    Palczuk, N.C.3    Davis, F.F.4
  • 44
    • 0017388651 scopus 로고
    • Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase
    • Abuchowski, A. McCoy, J. R. Palczuk, N. C. Es, T. V. and Davis, F. F. (1977) Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase. J. Biol. Chem. 252, 3582-3586.
    • (1977) J. Biol. Chem. , vol.252 , pp. 3582-3586
    • Abuchowski, A.1    McCoy, J.R.2    Palczuk, N.C.3    Es, T.V.4    Davis, F.F.5
  • 45
    • 0019849660 scopus 로고
    • Neocarzinostatin in cancer chemotherapy—A review
    • Maeda, H. (1981) Neocarzinostatin in cancer chemotherapy—A review. Anticancer Res. 1, 175-186.
    • (1981) Anticancer Res. , vol.1 , pp. 175-186
    • Maeda, H.1
  • 46
    • 0018241874 scopus 로고    scopus 로고
    • Experimental and clinical studies on the formation of antibody to neocarzinostatin, a new protein antibiotic
    • Yatamoto, S., Maeda, H., Matsumoto, T., and Ogata, J. Experimental and clinical studies on the formation of antibody to neocarzinostatin, a new protein antibiotic. Cancer Treat, Rep. 62, 2063-2070.
    • Cancer Treat, Rep. , vol.62 , pp. 2063-2070
    • Yatamoto, S.1    Maeda, H.2    Matsumoto, T.3    Ogata, J.4
  • 47
    • 0024556782 scopus 로고
    • Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I. Synthesis and characterization
    • Takakura, T. Kaneko, Y. Fujita, T., Hashida, M., Maeda, H., and Sezaki, H. (1989) Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. I. Synthesis and characterization. J. Pharm. Sci. 78, 117-121.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 117-121
    • Takakura, T.1    Kaneko, Y.2    Fujita, T.3    Hashida, M.4    Maeda, H.5    Sezaki, H.6
  • 48
    • 0024509652 scopus 로고
    • Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II. Biophar-maceutical and pharmacological properties
    • Takakura, Y., Fujita, T. Hashida, M., Maeda, H. and Sezaki, H. (1989) Control of pharmaceutical properties of soybean trypsin inhibitor by conjugation with dextran. II. Biophar-maceutical and pharmacological properties. J. Pharm. Sci. 78, 219-222.
    • (1989) J. Pharm. Sci. , vol.78 , pp. 219-222
    • Takakura, Y.1    Fujita, T.2    Hashida, M.3    Maeda, H.4    Sezaki, H.5
  • 49
    • 0023712086 scopus 로고    scopus 로고
    • A new tactic for the treatment of jaundice: An injectable polymer-conjugated bilirubin oxidase
    • Kimura, M., Matsumura, Y., Miyauchi, Y., and Maeda, H. A new tactic for the treatment of jaundice: An injectable polymer-conjugated bilirubin oxidase. Proc. Soc. Exp. Biol Med. 188, 364-369.
    • Proc. Soc. Exp. Biol Med. , vol.188 , pp. 364-369
    • Kimura, M.1    Matsumura, Y.2    Miyauchi, Y.3    Maeda, H.4
  • 51
    • 0001365675 scopus 로고
    • Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in murine Meth A sarcoma model
    • Katre, N. V., Knauf, M. J. and Laird, W.-J., (1987) Chemical modification of recombinant interleukin 2 by polyethylene glycol increases its potency in murine Meth A sarcoma model. Proc. Natl. Acad. Sci. 84t, 1487-1491.
    • (1987) Proc. Natl. Acad. Sci. , vol.84t , pp. 1487-1491
    • Katre, N.V.1    Knauf, M.J.2    Laird, W.-J.3
  • 52
    • 0025989090 scopus 로고
    • Effect of recombinant a-interferon-gelatin conjugate on in vivo murine tumor cell growth
    • Tabata, Y., Yamaoka, T., Ikada, Y. and Muramatsu, S. (1991) Effect of recombinant a-interferon-gelatin conjugate on in vivo murine tumor cell growth. Cancer Res. 51, 5532-5538.
    • (1991) Cancer Res. , vol.51 , pp. 5532-5538
    • Tabata, Y.1    Yamaoka, T.2    Ikada, Y.3    Muramatsu, S.4
  • 54
    • 0022473051 scopus 로고
    • Reexamination of the primary structure of an antitumor protein, neocarzinostatin
    • Kuromizu, M.H. Tsunasawa, S., Maeda, H., Abe, O., and Sakiyama, F. (1986) Reexamination of the primary structure of an antitumor protein, neocarzinostatin. Arch. Biochem. Biophys, 246, 199-205.
    • (1986) Arch. Biochem. Biophys , vol.246 , pp. 199-205
    • Kuromizu, M.H.1    Tsunasawa, S.2    Maeda, H.3    Abe, O.4    Sakiyama, F.5
  • 55
    • 0025726960 scopus 로고
    • Location of the disulfide bonds in the antitumor protein, neocarzinostatin
    • Kuromizu, M.H. Abe, O., and Maeda, H. (1991) Location of the disulfide bonds in the antitumor protein, neocarzinostatin. Arch. Biochem. Biphys, 286, 569-573.
    • (1991) Arch. Biochem. Biphys , vol.286 , pp. 569-573
    • Kuromizu, M.H.1    Abe, O.2    Maeda, H.3
  • 56
    • 0021960376 scopus 로고
    • The structure of neocarzinostatin chromophore possessing a novel bicyclo-(7, 3, 0)-dodecadiyne system
    • Edo, K. Mizugaki, M., Koide, Y., Seto, H. Furihata, K. Otake, N., and Ishida, N. (1985) The structure of neocarzinostatin chromophore possessing a novel bicyclo-(7, 3, 0)-dodecadiyne system Tetrahedron Lett. 26, 331-334.
    • (1985) Tetrahedron Lett. , vol.26 , pp. 331-334
    • Edo, K.1    Mizugaki, M.2    Koide, Y.3    Seto, H.4    Furihata, K.5    Otake, N.6    Ishida, N.7
  • 58
    • 0021908189 scopus 로고    scopus 로고
    • Conjugation of poly(styrene-co-maleic acid) derivative to the antitumor protein neocarzinostatin: Pronounced improvements in pharmacological properties
    • Maeda, H., Ueda, M., Morinaga, T., and Matsumoto, T. Conjugation of poly(styrene-co-maleic acid) derivative to the antitumor protein neocarzinostatin: Pronounced improvements in pharmacological properties. J. Med. Chem. 29, 455-461.
    • J. Med. Chem. , vol.29 , pp. 455-461
    • Maeda, H.1    Ueda, M.2    Morinaga, T.3    Matsumoto, T.4
  • 59
    • 0024392803 scopus 로고    scopus 로고
    • Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture
    • Oda, T., Sato, F. Yamamoto, H., Akagi, M., and Maeda, H. Cytotoxicity of smancs in comparison with other anticancer agents against various cells in culture. Anticancer Res. 9, 261-266.
    • Anticancer Res. , vol.9 , pp. 261-266
    • Oda, T.1    Sato, F.2    Yamamoto, H.3    Akagi, M.4    Maeda, H.5
  • 61
    • 0022586791 scopus 로고
    • Stimulation of macrophage by polyanions and its conjugated proteins and effect on cell membrane
    • Oda, T., Morinaga, T., and Maeda, H. (1986) Stimulation of macrophage by polyanions and its conjugated proteins and effect on cell membrane. Proc. Soc. Exp. Biol Med. 181, 9-17.
    • (1986) Proc. Soc. Exp. Biol Med. , vol.181 , pp. 9-17
    • Oda, T.1    Morinaga, T.2    Maeda, H.3
  • 62
    • 0024393389 scopus 로고
    • Stimulation of non-specific resistance to tumor in the mouse using a poly-(maleic acid-styrene) conjugated neocarzinostatin
    • Suzuki, F. Pollard, R. B., and Maeda, H. (1989) Stimulation of non-specific resistance to tumor in the mouse using a poly-(maleic acid-styrene) conjugated neocarzinostatin. Cancer ImmunoL Immunother. 30, 97-104.
    • (1989) Cancer ImmunoL Immunother. , vol.30 , pp. 97-104
    • Suzuki, F.1    Pollard, R.B.2    Maeda, H.3
  • 63
    • 0025327994 scopus 로고
    • Role of natural killer cells and macrophages in the non-specific resistance to tumors in mice stimulated with SMANCS. A polymer-conjugated derivative of neocarzinostatin
    • Suzuki, F. Pollard, R. B. Uchimura, S. Munakata, T. and Maeda, H. (1990) Role of natural killer cells and macrophages in the non-specific resistance to tumors in mice stimulated with SMANCS. A polymer-conjugated derivative of neocarzinostatin. Cancer Res, 50, 3897-3904.
    • (1990) Cancer Res , vol.50 , pp. 3897-3904
    • Suzuki, F.1    Pollard, R.B.2    Uchimura, S.3    Munakata, T.4    Maeda, H.5
  • 64
    • 0026138425 scopus 로고
    • Synthetic polymers with intrinsic anticancer activity
    • Seymour, L. (1991) Synthetic polymers with intrinsic anticancer activity. J. Bioact. Compat. Polym. 6, 178-216.
    • (1991) J. Bioact. Compat. Polym. , vol.6 , pp. 178-216
    • Seymour, L.1
  • 65
    • 0022512127 scopus 로고
    • Stability of high molecular weight anticancer agent SMANCS and its transfer from oil-phase to water-phase
    • Hirayama, S. Sato, F. Oda, T., and Maeda, H. (1986) Stability of high molecular weight anticancer agent SMANCS and its transfer from oil-phase to water-phase. Jpn. J. Antibiot. 39, 815-822.
    • (1986) Jpn. J. Antibiot. , vol.39 , pp. 815-822
    • Hirayama, S.1    Sato, F.2    Oda, T.3    Maeda, H.4
  • 66
    • 0002649813 scopus 로고
    • Targeting chemotherapy of hepatocellular carcinoma: arterial administration of smancs/ lipiodol
    • K. Okuda and K. G. Ishak, Ed.) Chapter 27 Springer-Verlag, New York.
    • Konno, T., and Maeda, H. (1987) Targeting chemotherapy of hepatocellular carcinoma: arterial administration of smancs/ lipiodol. Neoplasm of the Liver (K. Okuda and K. G. Ishak, Ed.) Chapter 27, pp 343-352, Springer-Verlag, New York.
    • (1987) Neoplasm of the Liver , pp. 343-352
    • Konno, T.1    Maeda, H.2
  • 67
    • 0025973522 scopus 로고
    • Tumor targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma
    • Kobayashi, M., Imai, K., Sugihara, S., Maeda, H., Konno, T., and Yamanaka, H. (1991) Tumor targeted chemotherapy with lipid contrast medium and macromolecular anticancer drug (SMANCS) for renal cell carcinoma. Urology. 37, 288-294.
    • (1991) Urology , vol.37 , pp. 288-294
    • Kobayashi, M.1    Imai, K.2    Sugihara, S.3    Maeda, H.4    Konno, T.5    Yamanaka, H.6
  • 68
    • 0026589130 scopus 로고
    • Antitumor effects of SMANCS on rat mammary tumor induced by 7, 12 dimethylbenz[a]anthracene
    • Kimoto, A., Konno, T. Kawaguchi, T. Miyauchi, Y. and Maeda, H. (1992) Antitumor effects of SMANCS on rat mammary tumor induced by 7, 12 dimethylbenz[a]anthracene. Cancer Res. 52, 1013-1017.
    • (1992) Cancer Res. , vol.52 , pp. 1013-1017
    • Kimoto, A.1    Konno, T.2    Kawaguchi, T.3    Miyauchi, Y.4    Maeda, H.5
  • 69
    • 0026535566 scopus 로고
    • The tumor blood vessel as an ideal target for macromolecular anticancer agents
    • Maeda, H. (1992) The tumor blood vessel as an ideal target for macromolecular anticancer agents. J. Controlled Release 19, 315-324.
    • (1992) J. Controlled Release , vol.19 , pp. 315-324
    • Maeda, H.1
  • 70
    • 0025317220 scopus 로고
    • Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinylether-maleic acid copolymer
    • Yamamoto, H. Miki, T. Oda, T., Hirano, T. Sera, Y. Akagi, M., and Maeda, H. (1990) Reduced bone marrow toxicity of neocarzinostatin by conjugation with divinylether-maleic acid copolymer. Eur. J. Cancer 26, 253-260.
    • (1990) Eur. J. Cancer , vol.26 , pp. 253-260
    • Yamamoto, H.1    Miki, T.2    Oda, T.3    Hirano, T.4    Sera, Y.5    Akagi, M.6    Maeda, H.7
  • 71
    • 0023764991 scopus 로고
    • Improvement of pharmacological properties of protein drug by tailoring with synthetic polymers
    • Maeda, H., Oda, T., Matsumura, Y., and Kimura, M. (1988) Improvement of pharmacological properties of protein drug by tailoring with synthetic polymers. J. Bioact. Compat. Polym. 3, 27-43.
    • (1988) J. Bioact. Compat. Polym. , vol.3 , pp. 27-43
    • Maeda, H.1    Oda, T.2    Matsumura, Y.3    Kimura, M.4
  • 75
    • 0019462687 scopus 로고
    • The preparation of mitomycin C, adriamycin and daunomycin covalently bound to antibodies as improved cancer chemotherapeutic agents
    • Suzuki, T., Sato, E., Goto, K., Katsurada, Y, Unno, M.H. and Takahashi, T. (1981) The preparation of mitomycin C, adriamycin and daunomycin covalently bound to antibodies as improved cancer chemotherapeutic agents. Chem. Pharm. Bull. 29, 844-848.
    • (1981) Chem. Pharm. Bull. , vol.29 , pp. 844-848
    • Suzuki, T.1    Sato, E.2    Goto, K.3    Katsurada, Y.4    Unno, M.H.5    Takahashi, T.6
  • 76
    • 0022273714 scopus 로고    scopus 로고
    • Controlled release of drug model from N-(2-hydroxypropyl)methacrylamide copolymers
    • Kopecek, J., Rejmanova, P., Duncan, R., and Lloyd, J. B. Controlled release of drug model from N-(2-hydroxypropyl)methacrylamide copolymers. Ann. N.Y. Acad. Sci. 446, 93-104.
    • Ann. N.Y. Acad. Sci. , vol.446 , pp. 93-104
    • Kopecek, J.1    Rejmanova, P.2    Duncan, R.3    Lloyd, J.B.4
  • 77
    • 0003051340 scopus 로고
    • Immunogenicity of N-(2-hydroxypropyl)methacrylamide copolymers
    • Rihova, B. Kopecek, J. Ulbrich, K. and Chytry, V. (1985) Immunogenicity of N-(2-hydroxypropyl)methacrylamide copolymers. Makromol. Chem” Supplement 9, 13-24.
    • (1985) Makromol. Chem” , pp. 13-24
    • Rihova, B.1    Kopecek, J.2    Ulbrich, K.3    Chytry, V.4
  • 78
    • 0021932454 scopus 로고
    • Biological effects of soluble synthetic polymers as drug carriers
    • Duncan, R. (1985) Biological effects of soluble synthetic polymers as drug carriers. CRC Crit, Rev, Ther. Drug Carrier Syst. 4t, 281-310.
    • (1985) CRC Crit, Rev, Ther. Drug Carrier Syst. , vol.4t , pp. 281-310
    • Duncan, R.1
  • 79
    • 0024398880 scopus 로고
    • Biocompatibility of N-(2-hydroxypropyl)methacrylamide copolymers containing adriamycin., Immunogenicity, effect on haematopoietic stem cells in bone marrow in vivo and effect on mouse spleenocytes and human peripheral blood lymphocytes in vitro
    • Rihova, B. Ulbrich, K. Strohalm, J. Vetvicka, V. Bilej, M., Duncan, R., and Kopecek, J. (1989) Biocompatibility of N-(2-hydroxypropyl)methacrylamide copolymers containing adriamycin. Immunogenicity, effect on haematopoietic stem cells in bone marrow in vivo and effect on mouse spleenocytes and human peripheral blood lymphocytes in vitro. Biomaterials 10t, 335-342.
    • (1989) Biomaterials , vol.10t , pp. 335-342
    • Rihova, B.1    Ulbrich, K.2    Strohalm, J.3    Vetvicka, V.4    Bilej, M.5    Duncan, R.6    Kopecek, J.7
  • 80
    • 0024439808 scopus 로고
    • Evaluation of antibody-N-(2-hydroxypropyl)-methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of anti-transferrin receptor antibody-conjugates
    • Flanagan, P. A., Kopeckova, P., Kopecek, J., and Duncan, R. (1989) Evaluation of antibody-N-(2-hydroxypropyl)-methacrylamide copolymer conjugates as targetable drug carriers. 1. Binding, pinocytic uptake and intracellular distribution of anti-transferrin receptor antibody-conjugates. Biochim. Biophys. Acta 993, 83-91.
    • (1989) Biochim. Biophys. Acta , vol.993 , pp. 83-91
    • Flanagan, P.A.1    Kopeckova, P.2    Kopecek, J.3    Duncan, R.4
  • 81
    • 0025283251 scopus 로고
    • Immunogenicity of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates measured in A/J and B10 mice
    • Flanagan, P. A. Rihova, B. Subr, V. Kopecek, J. and Duncan, R. (1990) Immunogenicity of protein-N-(2-hydroxypropyl)methacrylamide copolymer conjugates measured in A/J and B10 mice. J. Bioact. Compat. Polym. 5, 151-166.
    • (1990) J. Bioact. Compat. Polym. , vol.5 , pp. 151-166
    • Flanagan, P.A.1    Rihova, B.2    Subr, V.3    Kopecek, J.4    Duncan, R.5
  • 83
    • 85021503443 scopus 로고    scopus 로고
    • Macromolecular prodrugs containing doxorubicin and melanocyte stimulating hormone in vitro and in vivo evaluation against murine melanoma
    • in press).
    • O'hare, M.H.B., Duncan, R., Strohalm, J., Kopeckova, P., Kopecek, J., and Ulbrich, K. Macromolecular prodrugs containing doxorubicin and melanocyte stimulating hormone in vitro and in vivo evaluation against murine melanoma. Br. J. Cancer (in press).
    • Br. J. Cancer
    • O'hare, M.H.B.1    Duncan, R.2    Strohalm, J.3    Kopeckova, P.4    Kopecek, J.5    Ulbrich, K.6
  • 84
    • 0022635574 scopus 로고
    • N-(2-hydroxypropyl)-methacrylamide copolymers with pendant galactosamine residues. Fate after intravenous administration to rats
    • Duncan, R. Seymour, L. C. W. Scarlett, L. Lloyd, J. B. Rejmanova, P. and Kopecek, J. (1986) N-(2-hydroxypropyl)-methacrylamide copolymers with pendant galactosamine residues. Fate after intravenous administration to rats. Biochim. Biophys. Acta 880, 62-71.
    • (1986) Biochim. Biophys. Acta , vol.880 , pp. 62-71
    • Duncan, R.1    Seymour, L.C.W.2    Scarlett, L.3    Lloyd, J.B.4    Rejmanova, P.5    Kopecek, J.6
  • 85
    • 0025809808 scopus 로고
    • Pharmacokinetics of a polymeric drug carrier targeted to the hepatocyte galactose receptor
    • Seymour, L. W., Ulbrich, M.H. Strohalm, J., and Duncan, R. (1991) Pharmacokinetics of a polymeric drug carrier targeted to the hepatocyte galactose receptor. Br. J. Cancer 63, 859-866.
    • (1991) Br. J. Cancer , vol.63 , pp. 859-866
    • Seymour, L.W.1    Ulbrich, M.H.2    Strohalm, J.3    Duncan, R.4
  • 86
    • 0025189676 scopus 로고
    • Distribution of doxorubicin to normal breast and tumor tissue in patients undergoing mastectomy
    • Stallard, S. Morrison, J. G. George, W. D., and Kaye, S. B. (1990) Distribution of doxorubicin to normal breast and tumor tissue in patients undergoing mastectomy. Cancer Chemother. Pharmacol. 25, 286-290.
    • (1990) Cancer Chemother. Pharmacol. , vol.25 , pp. 286-290
    • Stallard, S.1    Morrison, J.G.2    George, W.D.3    Kaye, S.B.4
  • 88
    • 0023829660 scopus 로고
    • Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 2. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia
    • Duncan, R., Kopeckova-Rejmanova, P., Strohalm, J., Hume, I., Lloyd, J. B., and Kopecek, J. (1988) Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 2. Evaluation of daunomycin conjugates in vivo against L1210 leukaemia. Br. J. Cancer 57, 147-156.
    • (1988) Br. J. Cancer , vol.57 , pp. 147-156
    • Duncan, R.1    Kopeckova-Rejmanova, P.2    Strohalm, J.3    Hume, I.4    Lloyd, J.B.5    Kopecek, J.6
  • 89
    • 0024469053 scopus 로고
    • Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo
    • Duncan, R., Hume, I. C., Kopeckova, P., Ulbrich, M.H. Strohalm, J., and Kopecek, J. (1989) Anticancer agents coupled to N-(2-hydroxypropyl)methacrylamide copolymers. 3. Evaluation of adriamycin conjugates against mouse leukaemia L1210 in vivo. J. Controlled Release 10, 51-63.
    • (1989) J. Controlled Release , vol.10 , pp. 51-63
    • Duncan, R.1    Hume, I.C.2    Kopeckova, P.3    Ulbrich, M.H.4    Strohalm, J.5    Kopecek, J.6
  • 90
    • 0017874190 scopus 로고
    • Higher antitumor efficacy of daunomycin when linked to dextran: In vivo and in vitro studies
    • Bernstein, A. Hurwitz, E. Maron, R. Arnon, R. Sela, M., and Wilchek, M. (1978) Higher antitumor efficacy of daunomycin when linked to dextran: In vivo and in vitro studies. J. Natl. Cancer Inst. 60, 379-384.
    • (1978) J. Natl. Cancer Inst. , vol.60 , pp. 379-384
    • Bernstein, A.1    Hurwitz, E.2    Maron, R.3    Arnon, R.4    Sela, M.5    Wilchek, M.6
  • 91
    • 0004833668 scopus 로고
    • Pharmacokinetics of adriamycin-oxidized dextran conjugate (ADM-OXD) in experimental animals (in Japanese)
    • Fujita, H., Okamoto, M., and Takao, A. (1991) Pharmacokinetics of adriamycin-oxidized dextran conjugate (ADM-OXD) in experimental animals (in Japanese). Drug Delivery Syst. 6, 133-138.
    • (1991) Drug Delivery Syst. , vol.6 , pp. 133-138
    • Fujita, H.1    Okamoto, M.2    Takao, A.3
  • 92
    • 0014202956 scopus 로고
    • Interferon induction in man by a synthetic polyanion of defined composition
    • Merigan, T. C., and Regelson, W. (1967) Interferon induction in man by a synthetic polyanion of defined composition. N. Engl. J. Med. 277, 1283-1287.
    • (1967) N. Engl. J. Med. , vol.277 , pp. 1283-1287
    • Merigan, T.C.1    Regelson, W.2
  • 93
    • 0001741852 scopus 로고
    • Synthesis of antitumor-active conjugates of adriamycin or daunomycin with the copolymer of divinyl ether and maleic anhydride
    • Hirano, T., Ohashi, S. Morimoto, S. Tsuda, K. Kobayashi, T., and Tsukagoshi, S. (1986) Synthesis of antitumor-active conjugates of adriamycin or daunomycin with the copolymer of divinyl ether and maleic anhydride. Makromol. Chem. 187, 2815-2824.
    • (1986) Makromol. Chem. , vol.187 , pp. 2815-2824
    • Hirano, T.1    Ohashi, S.2    Morimoto, S.3    Tsuda, K.4    Kobayashi, T.5    Tsukagoshi, S.6
  • 95
    • 0021633364 scopus 로고
    • Macromolecule-drug conjugates in targeted cancer chemotherapy
    • Sezaki, H., and Hashida, M. (1984) Macromolecule-drug conjugates in targeted cancer chemotherapy. CRC Crit. Rev. Ther. Drug Carrier Syst. 1, 1-38.
    • (1984) CRC Crit. Rev. Ther. Drug Carrier Syst. , vol.1 , pp. 1-38
    • Sezaki, H.1    Hashida, M.2
  • 96
    • 0023240259 scopus 로고
    • Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugte with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities
    • Takakura, Y., Kitajima, M., Matsumoto, S. Hashida, M., and Sezaki, H. (1987) Development of a novel polymeric prodrug of mitomycin C, mitomycin C-dextran conjugte with anionic charge. I. Physicochemical characteristics and in vivo and in vitro antitumor activities. Int. J. Pharm. 37, 135-143.
    • (1987) Int. J. Pharm. , vol.37 , pp. 135-143
    • Takakura, Y.1    Kitajima, M.2    Matsumoto, S.3    Hashida, M.4    Sezaki, H.5
  • 97
    • 0023748863 scopus 로고
    • Selective accumulation of a new antineoplastic agent, K-18 (human immunoglobulin conjugated melphalan), in Ehrlich carcinoma transplanted in mice
    • Nio, Y. Imai, S. Ohgaki, M.H. and Tobe, T. (1988) Selective accumulation of a new antineoplastic agent, K-18 (human immunoglobulin conjugated melphalan), in Ehrlich carcinoma transplanted in mice. In Vivo 2, 177-188.
    • (1988) In Vivo , vol.2 , pp. 177-188
    • Nio, Y.1    Imai, S.2    Ohgaki, M.H.3    Tobe, T.4
  • 98
    • 0023222593 scopus 로고
    • Increased therapeutic efficacy and reduced toxicity of doxorubicin linked to pyran copolymer via the side chain of the drug
    • Zunino, F., Pratesi, G., and Pezzoni, G. (1987) Increased therapeutic efficacy and reduced toxicity of doxorubicin linked to pyran copolymer via the side chain of the drug. Cancer Treat. Rep, 71, 367-373.
    • (1987) Cancer Treat. Rep , vol.71 , pp. 367-373
    • Zunino, F.1    Pratesi, G.2    Pezzoni, G.3
  • 99
    • 0006052482 scopus 로고
    • A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro
    • in V, V, studies. U.S.A.
    • Trouet, A., Masquelier, M., Baurain, R., and Campeneere, D.D.-D. (1982) A covalent linkage between daunorubicin and proteins that is stable in serum and reversible by lysosomal hydrolases, as required for a lysosomotropic drug-carrier conjugate: in vitro and in V, V, studies. Proc. Natl. Acad. Sci. U.S.A. 79, 626-629.
    • (1982) Proc. Natl. Acad. Sci. , vol.79 , pp. 626-629
    • Trouet, A.1    Masquelier, M.2    Baurain, R.3    Campeneere, D.D.-D.4
  • 100
    • 0344119716 scopus 로고
    • Transferrin receptors of tumor cells-potential tools for diagnosis and treatment of malignancies
    • J., Spik J. Montreuil R. R. Crichton, and J., Mazurier, Eds. Elsevier Science Publishers,. V., Amsterdam.
    • Kohgo, Y. Nittsu, Y., Nishisato, T. Urushizaki, Y. Kondo, H., Fukushima, M., Tsushima, N., and Urushizaki, I. (1985) Transferrin receptors of tumor cells-potential tools for diagnosis and treatment of malignancies. In Proteins of iron storage and transport. (J. Spik, J. Montreuil, R. R. Crichton, and J. Mazurier, Eds.) pp 155-169, Elsevier Science Publishers,. V., Amsterdam.
    • (1985) Proteins of iron storage and transport. , pp. 155-169
    • Kohgo, Y.1    Nittsu, Y.2    Nishisato, T.3    Urushizaki, Y.4    Kondo, H.5    Fukushima, M.6    Tsushima, N.7    Urushizaki, I.8
  • 101
    • 0023038740 scopus 로고    scopus 로고
    • Activity of doxorubicin linked to poly-L-asparatic acid on normal murine hematopoietic progenitor cells
    • Bogliolo, G., Muzzulini, C., Lerza, R., and Pannacciulli, I. Activity of doxorubicin linked to poly-L-asparatic acid on normal murine hematopoietic progenitor cells. Cancer Treat. Rep. 70, 1275-1281.
    • Cancer Treat. Rep. , vol.70 , pp. 1275-1281
    • Bogliolo, G.1    Muzzulini, C.2    Lerza, R.3    Pannacciulli, I.4
  • 102
    • 0021741835 scopus 로고
    • Biological approaches to the controlled delivery of drugs: A critical review
    • Poznansky, M. J., and Juliano, R. L. (1984) Biological approaches to the controlled delivery of drugs: A critical review. Pharmacol.Rev. 36, 277-336.
    • (1984) Pharmacol.Rev. , vol.36 , pp. 277-336
    • Poznansky, M.J.1    Juliano, R.L.2
  • 103
    • 0026212613 scopus 로고
    • In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate
    • Wallace, P. M. and Senter, P. D. (1991) In vitro and in vivo activities of monoclonal antibody-alkaline phosphatase conjugates in combination with phenol mustard phosphate. Bioconjugate Chem. 2t, 349-352.
    • (1991) Bioconjugate Chem. , vol.2t , pp. 349-352
    • Wallace, P.M.1    Senter, P.D.2
  • 104
    • 0025194134 scopus 로고
    • The potential of carboxypeptidase G2: Antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model
    • Melton, R. G., Searle, F., Sherwood, R. F. Bagshawe, M. H. D., and Bden, J. A. (1990) The potential of carboxypeptidase G2: Antibody conjugates as anti-tumour agents. II. In vivo localising and clearance properties in a choriocarcinoma model. Br. J. Cancer 61, 420-424.
    • (1990) Br. J. Cancer , vol.61 , pp. 420-424
    • Melton, R.G.1    Searle, F.2    Sherwood, R.F.3    Bagshawe, M.H.D.4    Bden, J.A.5
  • 107
    • 0025917069 scopus 로고
    • Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver métastasés
    • Goldberg, J. A., Thomson, J. A. K. Brodnam, M. S. Fenner, J. Bessent, R. G., McKillop, J. H., Kerr, D. J. and McArdle, C. S. (1991) Angiotensin II as a potential method of targeting cytotoxic-loaded microspheres in patients with colorectal liver métastasés. Br. J. Cancer 64, 114-119
    • (1991) Br. J. Cancer , vol.64 , pp. 114-119
    • Goldberg, J.A.1    Thomson, J.A.K.2    Brodnam, M.S.3    Fenner, J.4    Bessent, R.G.5    McKillop, J.H.6    Kerr, D.J.7    McArdle, C.S.8
  • 109
    • 0016293021 scopus 로고
    • Pancreatic ribonuclease: enzymatic and physiological properties of a crosslinked dimer
    • Bartholeyns, J., and Moore, S. (1974) Pancreatic ribonuclease: enzymatic and physiological properties of a crosslinked dimer. Science 186, 444-445.
    • (1974) Science , vol.186 , pp. 444-445
    • Bartholeyns, J.1    Moore, S.2
  • 110
    • 0016693452 scopus 로고
    • Rapid uptake by liver sinusoidal cells of serum albumin modified with retention of its compact conformation
    • Buys, C. H. C. M., Dejong, A. S. H., Bouma, J. D. W., and Gruber, M. (1975) Rapid uptake by liver sinusoidal cells of serum albumin modified with retention of its compact conformation. Biochim. Biophys. Acta 392, 95-100.
    • (1975) Biochim. Biophys. Acta , vol.392 , pp. 95-100
    • Buys, C.H.C.M.1    Dejong, A.S.H.2    Bouma, J.D.W.3    Gruber, M.4
  • 111
    • 0021930366 scopus 로고
    • Binding and endocytosis of a2-macroglobulin-plasmin complex
    • Ney, K. A., Gidwitz, S. and Pizzo, S. V. (1985) Binding and endocytosis of a2-macroglobulin-plasmin complex. Biochemistry 24, 4586-4592.
    • (1985) Biochemistry , vol.24 , pp. 4586-4592
    • Ney, K.A.1    Gidwitz, S.2    Pizzo, S.V.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.