In search of new lead compounds for trypanosomiasis drug design: A protein structure-based linked-fragment approach

Journal of Computer-Aided Molecular Design

Volumn 6, Issue 2, 1992, Pages 131-147

  Verlinde, Christophe L M J ^a   Rudenko, Gabrielle ^a   Hol, Wim G J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

Chemical database; Modular structure based inhibitor design; Triosephosphate isomerase

Indexed keywords

ANTITRYPANOSOMAL AGENT; LEAD; ORGANOMETALLIC COMPOUND; PROTEIN; TRIOSEPHOSPHATE ISOMERASE;

ANIMAL; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; ENZYMOLOGY; FACTUAL DATABASE; HUMAN; TRYPANOSOMA; TRYPANOSOMIASIS;

ANIMAL; BINDING SITES; DATABASES, FACTUAL; DRUG DESIGN; HUMAN; LEAD; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ORGANOMETALLIC COMPOUNDS; PROTEINS; SUPPORT, NON-U.S. GOV'T; TRIOSE-PHOSPHATE ISOMERASE; TRYPANOCIDAL AGENTS; TRYPANOSOMA; TRYPANOSOMIASIS;

EID: 0026848170     PISSN: 0920654X     EISSN: 15734951     Source Type: Journal    
DOI: 10.1007/BF00129424     Document Type: Article

References (50)

1. Molecular speleology: the exploration of crevices in proteins for prediction of binding sites, design of drugs and analysis of surface recognition
2. The Cambridge Crystallographic Data Centre: computer-based search, retrieval, analysis and display of information
3. ALADDIN: An integrated tool for computer-assisted molecular design and pharmacophore recognition from geometric, steric, and substructure searching of three-dimensional molecular structures