Myb: a transcriptional activator linking proliferation and differentiation in hematopoietic cells

Current Opinion in Genetics and Development

Volumn 2, Issue 2, 1992, Pages 249-255

  Graf, Thomas ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ONCOGENE PROTEINS V MYB; ONCOPROTEIN; PROTEIN C MYB; PROTO ONCOGENE PROTEINS; PROTO ONCOGENE PROTEINS C MYB; TRANSCRIPTION FACTOR;

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; CHEMISTRY; CYTOLOGY; GENE EXPRESSION REGULATION; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; PHYSIOLOGY; REVIEW;

ANIMAL; CELL DIFFERENTIATION; CELL DIVISION; GENE EXPRESSION REGULATION; HEMATOPOIETIC STEM CELLS; HUMAN; ONCOGENE PROTEINS V-MYB; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MYB; RETROVIRIDAE PROTEINS, ONCOGENIC; TRANSCRIPTION FACTORS;

EID: 0026844368     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(05)80281-3     Document Type: Article

References (42)

1. The myb Oncogene
2. The myb and myc Nuclear Oncogenes as Transcriptional Activators
3. New Light on MYC and MYB Part II MYB
4. A c-myb Antisense Oligonucleotide Inhibits Normal Human Hematopoiesis in Vitro
5. A Functional c-myb Gene is Required for Normal Murine Fetal Hepatic Hematopoiesis
6. Stage Related Proliferative Activity Determines c-myb Functional Requirements During Normal Hematopoiesis
7. Antisense Myb Inhibition of Purified Erythroid Progenitors in Development and Differentiation is Linked to Cycling Activity and Expression of DNA Polymerase α
8. Nuclear Oncoprotein Expression as a Function of Lineage, Differentiation Stage, and Proliferation Status of Normal Human Hematopoietic Cells
9. Normal and Leukemic Hematopoietic Cells Manifest Differential Sensitivity to Inhibitory Effects of c-myb Antisense Oligodeoxynucleotides: an in Vitro Study Relevant to Bone Marrow Purging
10. Down-regulated c-myb Expression Inhibits DNA Synthesis of T-leukemia Cells in Most Patients
11. Differentiation of Mouse Erytholeukemia Cells Enhanced by Alternatively Spliced c-myb mRNA
12. v-myb Dominance Over v-myc in Doubly Transformed Chick Myelomonocytic Cells
13. Estrogen-dependent Alterations in Differentiation State of Myeloid Cells Caused by a v-myb-estrogen Receptor Fusion Protein
14. Mutations in v-myb Alter the Differentiation of Myelomonocytic Cells Transformed by the Oncogene
15. A Single Point Mutation in the v-ets Gene of the E26 Avian Leukemia Virus Affects Both Erythroid and Myeloid Cell Transformation and Promotes a Lineage Conversion from Macrophages to Promyelocytes
16. The v-myb Oncogene Product Binds to and Activates the Promyelocyte-specific mim-1 Gene
17. Expression Patterns of c-myb and of v-myb Induced Myeloid-1 (mim-1) Gene During the Development of the Chick Embryo
18. Identification of Genes Differentially Expressed in Two Types of v-myb-transformed Avian Myelomonocytic Cells
19. Positive Autoregulation of c-myb Expression via Myb Binding Sites in the 5′ Flanking Region of the Human c-myb Gene
20. Interaction of the v- and c-Myb Proteins with Regulatory Sequences of the Human c-myc Gene
21. Activation of Transcription by v-myb: Evidence for Two Different Mechanisms
22. Expression Patterns of myb Genes from Antirrhinum Flowers
23. Targets for Trans-activation by myb
24. A myb Gene Required for Leaf Trichome Differentiation in Arabidopsis is Expressed in Stipules
25. Dictyostelium MYB: Evolution of a DNA-binding Domain
26. DNA-binding Domain Ancestry
27. Proposed Structure for the DNA-binding Domain of the Myb Oncoprotein Based on Model Building and Mutational Analysis
28. Specific DNA-binding by c-Myb: Evidence for a Double Helix-turn-helix-related Motif
29. The Tryptophan Cluster: a Hypothetical Structure of the DNA-binding Domain of the myb Protooncogene Product
30. Role of Tryptophan Repeats and Flanking Amino Acids in Myb-DNA Interactions
31. The POU Factors in Murine Development
32. Transcriptional Activation by the v-myb Oncogene and its Cellular Progenitor, c-myb
33. Delineation of Three Functional Domains of the Transcriptional Activator Encoded by the c-myb Protooncogene
34. Transformation by Carboxyl-detected Myb Reflects Increased Transactivating Capacity and Disruption of a Negative Regulatory Domain
35. Increase in Specific DNA-binding by Carboxyl Truncation Suggests a Mechanism for Activation of Myb
36. The Oct-1 Homeodomain Directs Formation of a Multiprotein-DNA Complex with the HSV Transactivator VP16
37. Protein Truncation is Required for the Activation of the c-myb Proto-oncogene
38. Transformation by v-myb Correlates with Trans-activation of Gene Expression
39. The ets Sequence is Required for Induction of Erythroblastosis in Chickens by Avian Retrovirus E26
40. Activation of cMGF Expression is a Critical Step in Avian Myeloid Leukemogenesis
41. v-myb and v-ets Transform Chicken Erythroid Cells and Cooperate Both in trans and in cis to Induce Distinct Differentiation Phenotypes
42. Fusion of the Nuclear Oncoproteins v-Myb and v-Ets is Required for the Leukemogenicity of E26 Virus