Suppression of high affinity IL-2 receptors on mitogen activated lymphocytes by glioma-derived suppressor factor

Journal of Neuro-Oncology

Volumn 14, Issue 1, 1992, Pages 1-7

  Elliott, Lucinda H ^a   Brooks, William H ^a   Roszman, Thomas L ^a  

^a UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

glioma derived suppressor factor (GSF); interleukin 2 (IL 2); interleukin 2 receptor (IL 2R); T cells, mitogen responsiveness

Indexed keywords

GLIOMA DERIVED SUPPRESSOR FACTOR; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; HUMAN; HUMAN CELL; T LYMPHOCYTE;

ANIMAL; BIOLOGICAL FACTORS; BRAIN NEOPLASMS; CELLS, CULTURED; CULTURE MEDIA, CONDITIONED; DOWN-REGULATION; GLIOBLASTOMA; HUMAN; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOCYTES; MICE; NEUROIMMUNOMODULATION; PHYTOHEMAGGLUTININS; RECEPTORS, INTERLEUKIN-2; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0026808520     PISSN: 0167594X     EISSN: 15737373     Source Type: Journal    
DOI: 10.1007/BF00170940     Document Type: Article

References (24)

1. Immunobiology of primary intracranial tumors. Part 5: Correlation of a lymphocyte index and clinical status
2. Inhibition of lymphocyte responsiveness by a glial tumor cell-derived suppressive factor
3. Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediating effects
4. Production of prostaglandin E and an interleukin 1-like factor by cultured astrocytes, and C6 glioma cells
5. T cell suppressor factor from human glioblastoma cells in a 12.5-kd protein closely related to transforming growth factor-beta
6. Paoletti: Prostaglandin and thromboxane synthesis by human intracranial tumors
7. T cell growth factor: parameters of production and quantitative microassay for activity
8. The interleukin-2 T cell system: A new cell growth model
9. Interleukin-2
10. Isolation of mononuclear cells and granulocytes from human blood. Isolation of mononuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation lg
11. Low and high affinity cellular receptors for interleukin 2
12. The interleukin 2 receptor functional consequences of its biomolecular structure
13. Modulation of T-cell function by gliomas
14. Partial purification and biochemical characterization of a T cell suppressor factor produced by human glioblastoma cells
15. Transforming growth factor-beta: Biological function and chemical structure
16. Expression of platelet-derived growth factors, transforming growth factors and the ras gene in a variety of primary human brain tumors
17. Malignant glioma modulation of immune function: relative contribution of different soluble factors
18. Depressed cell-mediated immunity in patients with primary intracranial tumors. Characterization of a Immoral immunosuppressive factor
19. Role of interleukin-2 (IL-2) and IL-2 receptor expression in the proliferative defect observed in mitogen-stimulated lymphocytes from patients with gliomas
20. Inability of antigen-activated lymphocytes obtained from patients with malignant primary intracranial tumors to express high affinity interleukin 2 receptors
21. The glioblastoma-derived T-cell suppressor factor-transforming growth factor beta 2 inhibits T-cell growth without affecting the interaction of interleukin 2 with its receptor
22. Contingent genetic regulatory events in T lymphocyte activation