No correlation between site of breakpoint in the BCR gene and platelet counts in philadelphia chromosome-positive CML

Leukemia Research

Volumn 16, Issue 9, 1992, Pages 937-939

  Opalka, B ^a   Wandl, U B ^a   Kloke, O ^a   Beer, U ^a   Seeber, S ^c   Niederle, N ^b  

^a UNIVERSITY HOSPITAL ESSEN   (Germany)

^b KLINIKUM LEVERKUSEN   (Germany)

^c Department of Internal Medicine III Städtisches Krankenhaus ^*

Author keywords

BCR gene; breakpoint localisation; CML; platelet counts

Indexed keywords

ARTICLE; CHROMOSOME BREAKAGE; CHRONIC MYELOID LEUKEMIA; DNA FLANKING REGION; GENE STRUCTURE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; PHILADELPHIA 1 CHROMOSOME; PRIORITY JOURNAL; PROTO ONCOGENE; THROMBOCYTE COUNT;

CHROMOSOME ABERRATIONS; CHROMOSOMES, HUMAN, PAIR 22; HUMAN; LEUKEMIA, MYELOID, PHILADELPHIA-POSITIVE; PLATELET COUNT; PROGNOSIS;

EID: 0026808512     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/0145-2126(92)90039-A     Document Type: Article

References (9)

1. The relationship between the site of breakpoints within the bcr gene and thrombopoiesis of Philadelphia-positive chronic myelocytic leukemia
2. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining
3. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia
4. Induction of chronic myelogenous leukemia in mice by the p210(bcr/abl) gene of the Philadelphia chromosome
5. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22
6. Does the site of the breakpoint on chromosome 22 influence the duration of the chronic phase in chronic myeloid leukemia?
7. A possible correlation between the type of bcr-abl hybrid messenter RNA and platelet count in Philadelphia-positive chronic myelogenous leukemia
8. Breakpoint localization within the M-bcr and clinical course do not correlate in patients with chronic myelogenous leukemia undergoing alfa interferon therapy
9. Proposal for a simple synthesis prognostic staging system in chronic myelogenous leukemia