Expression of the Cellular Adhesion Molecule E-Cadherin Is Reduced or Absent in High-Grade Prostate Cancer

Cancer Research

Volumn 52, Issue 18, 1992, Pages 5104-5109

  Isaacs, William B ^b,c   Carter, Bob S ^b,c   Debruyne, Frans M J ^a   Schalken, Jack A ^a  

^a Department of Urology/Urological Research Laboratories ^*  (Netherlands)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c JOHNS HOPKINS HOSPITAL   (United States)

^d CANISIUS WILHELMINA HOSPITAL   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CADHERIN; CELL ADHESION MOLECULE; TUMOR MARKER;

ARTICLE; CANCER INVASION; CANCER SCREENING; CANCER STAGING; CELL ADHESION; CELL DIFFERENTIATION; CELL INTERACTION; CHROMOSOME DELETION; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; PRIORITY JOURNAL; PROSTATE CANCER; SUPPRESSOR GENE; TUMOR CELL;

CADHERINS; CELL DIFFERENTIATION; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CHROMOSOME DISORDERS; CHROMOSOMES, HUMAN, PAIR 16; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; NEOPLASM METASTASIS; PROSTATE; PROSTATIC NEOPLASMS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0026795845     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (35)

1. Partin, A. W., Walsh, A. C., Pitcock, R. V., Mohler, J. L., Epstein, J. I., and Coffey, D. S. A comparison of nuclear morphometry and Gleason grade as a predictor of prognosis in stage A2 prostate cancer a critical analysis. J. Urol., 142: 1254-1258, 1989.
2. Carter, H. B., and Coflfey, D. S. Prediction of tumor behavior in prostate cancer. In: J. P. Karr and H. Yamanak (eds.). Prostate Cancer The Second Tokyo Symposium, pp. 19-27. New York: Elsevier, 1989.
3. Carter, B. S., Ewing, C. M., Ward, W. S., Treiger, B. F., Aalders, T. W., Schalken, J. A., Epstein, J. I., and Isaacs, W. B. Allelic loss of chromosomes 16q and lOq in human prostate cancer. Proc. Natl. Acad. Sci. USA, 87: 8751-8755, 1990.
4. Bergerheim, U. S. R., Kunimi, K., Collins, V. P., and Ekman, P. Deletion mapping of chromosomes 8,10 and 16 in human prostatic carcinoma. Genes Chromosomes Cancer, 3: 215-220, 1991.
5. Sato, T., Tanigami, A., Yamakawa, K., Akiyama, F., Kasumi, F., Sakamoto, G., and Nakamura, Y. Allelotype of breast cancer cumulative allele losses promote tumor progression in primary breast cancer. Cancer Res., 5A 7184-7189, 1990.
6. Tsuda, H., Zhang, W., Shimosato, Y., Yokota, J., Terada, M., Sugimura, T., Miyamura, T., and Hirohashi, S. Allele loss on chromosome 16 associated with progression of human hepatocellukv carcinoma. Proc. Natl. Acad. Sci. USA, 87:6791-6794, 1990.
7. Maw, M. A., Grundy, P. E., Millow, L. J., Eccles, M. R., Dunn, R. S., Smith, P. J., Feinberg, A. P., Law, D. J., Paterson, M. C., Telzerow, P. E., Callen, D. F., Thompson, A. D., Richards, R. I., and Reeve, A. E. A third Wilms tumor locus on chromosome 16q. Cancer Res., 52: 3094-3098, 1992.
8. Mareel, M. M., Behrens, J., Birchmeier, W., De Bruyne, G. K., Vleminckx, K., Hoogewys, A., Fiers, W. C., and Van Roy, F. M. Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDKC) cells inside tumors of nude mice. Int. J. Cancer, 47:922-928, 1991.
9. Vleminckx, K., Vakaet, L., Jr., Mareel, M., Fiers, W., and Van Roy, F. Genetic manipulation of Ecadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell, 66: 107-119, 1991.
10. Behrens, J., Mareel, M. M., Van Roy, F. M., and Birchmeier, W. Dissecting tumor cell invasion: epithelial cells acquire invasive properties after the loss of uvomorulin-mediated cell-cell adhesion. J. Cell Biol., 108: 2435-2447, 1989.
11. Frixen, U. H., Behrens, J., Sachs, M., Eberle, G., Voss, B., Warda, A., Lochner, D., and Birchmeier, W. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J. Cell Biol., IIB: 173-185, 1991.
12. Mansouri, A., Spurr, N., Goodfellow, P. N., and Kemler, R. Characterization and chromosomal localization of the gene encoding the human cell adhesion molecule uvomorulin. Differentiation, 38:67-71, 1988.
13. Takeichi, M. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis. Development, 102:639-655, 1988.
14. Edelman, G. M. Expression of cell adhesion molecules during embryogenesis and regeneration. Exp. Cell Res., 161: 1-16, 1984.
15. Edelman, G. M. Cell adhesion molecules in the regulation of animal form and tissue pattern. Ann. Rev. Cell Biol., 2: 81-116, 1986.
16. Angres, B., Muller, A. H. J., Kellermann, J., and Hausen, P. Differential expression of two cadherins in Xenopus laevis. Development, 111: 829-844, 1991.
17. Donalies, M., Cramer, M., Ringwald, M., and Starzinski-Powitz, A. Expression of M-cadherin, a member of the cadherin multigene family, correlates with differentiation of skeletal muscle cells. Proc. Natl. Acad. Sci. USA, 88: 8024-8028, 1991.
18. Ginsberg, D., DeSimone, D., and Geiger, B. Expression of a novel cadherin (EP-cadherin) in unfertilized eggs and early Xenopus embryos. Development, III: 315-325, 1991.
19. Napolitano, E. W., Venstrom, K., Wheeler, E. F., and Reichardt, L. F. Molecular cloning and characterization of B-cadherin, a novel chick cadherin. J. Cell Biol., 113:893-905, 1991.
20. Ranscht, B., and Bronner-Fraser, M. T-cadherin expression alternates with migrating neural crest cells in the trunk of the avian embryo. Development, 111: 15-22, 1991.
21. Suzuki, S., Sano, K., and Tanihara, H. Diversity of the cadherin family: evidence for eight new cadherins in nervous tissue. Cell Regulation, 2:261-270, 1991.
22. Takeichi, M. Cadherin cell adhesion receptors as a morphogenetic regulator. Science (Washington DC), 251: 1451-1455, 1991.
23. Hyafil, F., Babinet, C., and Jacob, F. Cell-cell interactions in early embryo-genesis: a molecular approach to the role of calcium. Cell, 26:447-454,1981.
24. Gallin, W. J., Edelman, G. M., and Cunningham, B. A. Characterization of L-CAM, a mtyor cell adhesion molecule from embryonic liver cells. Proc. Natl. Acad. Sci. USA, 80: 1038-1042, 1983.
25. Damsky, C. H., Richa, J., Solter, D., Knudsen, K., and Buck, C. A. Identification and purification of a cell surface glycoprotein mediating intercellular adhesion in embryonic and adult tissue. Cell, 34:455-466, 1983.
26. Imhof, B. A., Vollmers, H. P., Goodman, S. L., and Birchmeier, W. Cell-cell interaction and polarity of epithelial cells: specific perturbation using a monoclonal antibody. Cell, 35:667-675, 1983.
27. Behrens, J., Birchmeier, W., Goodman, S. L., and Imhof, B. A. Dissociation of Madin-Darby canine kidney epithelial cells by the monoclonal antibody anti-Arc-1: mechanistic aspects and identification of the antigen as a component related to uvomorulin. J. Cell Biol., 101: 1307-1315, 1985.
28. Shimoyama, Y., Hirohashi, S., Hirano, S., Noguchi, M., Shimosato, Y., Takeichi, M., and Abe, O. Cadherin cell-adhesion molecules in human epithelial tissues and carcinomas. Cancer Res., 49: 2128-2133, 1989.
29. Shimoyama, Y., and Hirohashi, S. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma. Cancer Lett., 57: 131-135, 1991.
30. Schipper, J. H., Frixen, U. H., Behrens, J., Unger, A., Jahnke, K., and Birchmeier, W. E-cadherin expression in squamous cell carcinomas of head and neck: inverse correlation with tumor dedifferentiation and lymph node metastasis. Cancer Res., 51:6328-6337, 1991.
31. Bussemakers, M. J. G., Van Moorselaar, R. J. A., Giroldi, L. A., Ichikawa, T., Isaacs, J. T., Takeichi, M., Debruyne, F. M. J., and Schalken, J. A. Decreased expression of E-cadherin in the progression of rat prostatic cancer. Cancer Res., 52:2916-2922,1992.
32. Gleason, D. F. Histologic grading and clinical staging of prosUtic carcinoma. In: M. Tannenbaum (ed.), Urologic Pathology: The Prostate, pp. 171-197. Philadelphia: Lea and Febiger, 1977.
33. Hashimoto, M., Niwa, O., Nitta, Y., Takeichi, M., and Yokoro, K. Unstable expression of E-cadherin adhesion molecules in metastatic ovarian tumor cells. Jpn. J. Cancer Res., 80:459-463, 1989.
34. Ligtenberg, M. J. L., Bujjs, F., Vos, H. L., and Hilkens, J. Suppression of cellular aggregation by high levels of episialin. Cancer Res., 52: 2318-2324, 1992.
35. Knudson, A. G. Mutation and cancen statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA, 68: 820-823, 1971.