Facile enzymatic preparation of enantiomeric p-lactams

Chemical and Pharmaceutical Bulletin

Volumn 40, Issue 8, 1992, Pages 2227-2229

  Nagai, Hazuki ^a   Shiozawa, Tatsushi ^a   Terao, Yoshiyasu ^a   Achiwa, Kazuo ^b  

^a Graduate School Of Nutritional & Environmental Sciences ^*  (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

esterification; hydrolysis; lipase; p lactam; resolution

Indexed keywords

BETA LACTAM DERIVATIVE; TRIACYLGLYCEROL LIPASE;

ARTICLE; DRUG SYNTHESIS; ENANTIOMER; ENZYME ACTIVITY;

EID: 0026794005     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.40.2227     Document Type: Article

References (4)

1. For recent reviews, see : D. J. Hart and D. C. Ha, Chem. Rev., 8 9, 1447 (1989); G. M. Coppola and H. F. Schuster, “Asymmetric Synthesis”, John Willy & Sons Inc., New York, 1987.
2. For resent reviews on enzymatic reactions, see: W. Boland, C. Frossl, and M. Lorenz, Synthesis, 1991, 1049; A. M. Klibanov, Acc. Chem. Res., 23, 114 (1990); M. Murata, H. Ebiike, and K. Achiwa, J. Syn. Org. Chem. Jpn., 49, 1127 (1991).
3. Lipase B: T. Nishio, T. Chikano, and M. Kamimura, Agric. Biol. Chem., 51, 181 (1987). Lipase PS was supplied by Amano Pharmaceutical Co., Ltd.
4. G. Cainelli, D. Giacomini, M. Panunzio, G. Martelli, andG. Spunta, Tetrahedron Lett., 28, 5369 (1987).