De novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite

Biochemical and Biophysical Research Communications

Volumn 187, Issue 2, 1992, Pages 744-750

  Surolia, Namita ^a   Padmanaban, Govindarajan ^a  

^a INDIAN INSTITUTE OF SCIENCE   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; HEMOGLOBIN; PORPHOBILINOGEN SYNTHASE; SUCCINYLACETONE;

ARTICLE; ENZYME ACTIVITY; ENZYME ASSAY; ERYTHROCYTE; HEME SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RADIOACTIVITY; TROPHOZOITE;

5-AMINOLEVULINATE SYNTHETASE; AMINOLEVULINIC ACID; ANIMAL; GLUTAMATES; GLUTAMIC ACID; HEME; HEPTANOATES; ISOLEUCINE; PLASMODIUM FALCIPARUM; PORPHOBILINOGEN SYNTHASE; PROTEINS; SUPPORT, NON-U.S. GOV'T;

PLASMODIUM FALCIPARUM;

EID: 0026785410     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/0006-291X(92)91258-R     Document Type: Article

References (19)

1. Sequences similar to genes for two mitochondrial proteins and portions of ribosomal RNA in tandemly arrayed 6-kilobase-pair DNA of a malarial parasite
2. Lysis of Plasmodium falciparum by ferriprotoporphyrin IX and a chloroquine-ferriprotoporphyrin IX complex.
3. Heme is a positive regulator of cytochrome P-450 gene transcription
4. tRNAGlu as a cofactor in δ-aminolevulinate biosynthesis: steps that regulate chlorophyll synthesis