Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog

Cell

Volumn 71, Issue 1, 1992, Pages 33-50

  Lee, John J ^a   von Kessler, Doris P ^a   Parks, Suki ^a   Beachy, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA;

ALLELE; AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL GENETICS; ARTICLE; DROSOPHILA; EMBRYO; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC MODEL; GENETIC TRANSCRIPTION; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TARGETING;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BLOTTING, NORTHERN; BLOTTING, SOUTHERN; DROSOPHILA; GENE EXPRESSION REGULATION; GENES, INSECT; LARVA; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; PROTEINS; RESTRICTION MAPPING; TRANSCRIPTION, GENETIC;

ANIMALIA; ERINACEIDAE;

EID: 0026783674     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90264-D     Document Type: Article

References (101)

1. The molecular basis for metameric pattern in the Drosophila embryo
2. Transcription of the segment-polarity gene wingless in the imaginal discs of Drosophila, and the phenotype of a pupallethal wg mutation
3. P-element-mediated enhancer detection: a versatile method to study development in Drosophila
4. Transcription factors and the control of Drosophila development
5. Expression of an activated ras gene causes developmental abnormalities in transgenic Drosophila melanogaster
6. engrailed expression in Drosophila imaginal discs
7. Clonal analysis of the undifferentiated wing disk of Drosophila
8. Functional cDNA libraries from Drosophila embryos
9. Pattern formation in the imaginal wing disc of Drosophila melanogaster: fate map, regeneration and duplication
10. Eukaryotic start and stop translation sites
11. Mediation of Drosophila head development by gap-like segmentation genes
12. Drosophila headlines
13. Establishment and refinement of segmental pattern in the Drosophila embryo: spatial control of engrailed expression by pair rule genes
14. Development of embryonic pattern in D. melanogaster as revealed by accumulation of the nuclear engrailed protein
15. Two-tiered regulation of spatially patterned engrailed gene expression during Drosophila embryogenesis
16. Analysis of membrane and surface protein sequences with the hydrophobic moment plot
17. Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila
18. Differential DNA sequence recognition is a determinant of specificity in homeotic gene action
19. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
20. The orthodenticle gene is regulated by bicoid and torso and specifies Drosophila head development
21. The molecular genetics of head development in Drosophila melanogaster
22. Isolation of a homeobox-containing gene from the engrailed region of Drosophila and the spatial distribution of its transcript
23. d mutant
24. DNA binding specificity of the fushi tarazu homeodomain
25. Rapid amplification of cDNA ends (RACE): user-friendly cDNA cloning
26. Secretion and movement of wingless protein in the epidermis of the Drosophila embryo
27. Region-specific recombination and expression are directed by portions of the Drosophila engrailed promoter
28. Dideoxy sequencing method using denatured plasmid templates
29. Development of the eye-antenna imaginal disc and morphogenesis of the adult head in Drosophila melanogaster
30. Multiple modes of engrailed regulation in the progression towards cell fate determination
31. Cell patterning in the Drosophila segment: spatial regulation of the segment polarity gene patched
32. 2-terminal signal sequence
33. Sequence homologies in the 5′ regions of four Drosophila heat-shock genes
34. The Drosophila patched gene encodes a putative membrane protein required for segmental patterning
35. Regulatory interactions between the segmentation genes fushi tarazu, hairy, and engrailed in the Drosophila blastoderm
36. Boundaries and fields in early embryos
37. The molecular genetics of embryonic pattern formation in Drosophila
38. Role of the Drosophila patched gene in positional signalling
39. Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene
40. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster II Zygotic loci on the third chromosome
41. Segmental organization of the head in the embryo of Drosophila melanogaster
42. Analysis of subtelomeric heterochromatin in the minichromosome Dp1187 by single P element insertional mutagenesis
43. Spatial and temporal control elements of the Drosophila engrailed gene
44. Sequence of the structural gene for Xanthine Dehydrogenase (rosy locus) in Drosophila melanogaster
45. engrailed: a gene controlling compartment and segment formation in Drosophila
46. The engrailed locus of Drosophila: in situ localization of transcripts reveals compartment-specific expression
47. Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila
48. A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF
49. A simple method for displaying the hydropathic character of a protein
50. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
51. Recognition of nascent polypeptides for targeting and folding
52. Immunological method for mapping genes on Drosophila polytene chromosomes
53. Interactions between fused, a segment polarity gene in Drosophila, and other segmentation genes
54. New heat shock puffs and β-galactosidase activity resulting from transformation of Drosophila with an hsp70-lacZ hybrid gene
55. The isolation of structural genes from libraries of eucaryotic DNA
56. Parasegments and compartments in the Drosophila embryo
57. Role of segment polarity genes in the definition and maintenance of cell states in the Drosophila embryo
58. Transforming growth factor-α: a model for membrane-anchored growth factors
59. Enhancer trap in Drosophila its applications to neurobiology
60. Requirements for hedgehog, a segmental polarity gene, in patterning larval and adult cuticle of Drosophila
61. Development of the eyeantenna imaginal disc of Drosophila
62. A protein with several possible membrane-spanning domains encoded by the Drosophila segment polarity gene patched
63. Mutations affecting segment number and polarity in Drosophila
64. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster I Zygotic loci on the second chromosome
65. Structures of P transposable elements and their sites of insertion and excision in the Drosophila melanogaster genome
66. Making stripes in the Drosophila embryo
67. The role of segment polarity genes during Drosophila neurogenesis
68. Improved tools for biological sequence comparison
69. The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin
70. The segment polarity gene armadillo interacts with the wingless signalling pathway in both embryonic and adult pattern formation
71. Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin
72. The Drosophila segment polarity gene patched is involved in a position-signalling mechanism in imaginal discs
73. The engrailed locus of Drosophila: structural analysis of an embryonic transcript
74. A putative serine-threonine protein kinase encoded by the segment-polarity fused gene of Drosophila
75. Poly(A) signals
76. A conformational preference parameter to predict helices in integral membrane proteins
77. The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless
78. Transcription of structural and intervening sequences in the ovalbumin gene and identification of potential ovalbumin mRNA precursors
79. DNA sequencing with chain-terminating inhibitors
80. Primary structure of human transferrin receptor deduced from the mRNA sequence
81. Mapping Z-DNA in the human genome
82. Regeneration, duplication and transdetermination in fragments of the leg disc of Drosophila melanogaster
83. RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression
84. Evidence for the loop model of signal sequence insertion into the endoplasmic reticulum
85. An internal signal sequence: the asialoglycoprotein receptor membrane anchor
86. Direct stimulation of cells expressing receptors for macrophage colony-stimulating factor (CSF-1) by a plasma membrane-bound precursor of human CSF-1
87. Establishment of compartments in the developing leg imaginal discs of Drosophila melanogaster
88. The complete sequence of the mRNA for the HLA-DR-associated invariant chain reveals a polypeptide with an unusual transmembrane polarity
89. Trans-sensing effects from Drosophila to humans
90. A non-radioactive in situ hybridization method for the localization of specific RNAs in the Drosophila embryo reveals translational control of the segmentation gene hunchback
91. Scanning electron microscopy of Drosophila melanogaster embryogenesis. III. Formation of the head and caudal segments
92. distribution of the wingless gene product in Drosophila embryos: a protein involved in cell-cell communication
93. The state of engrailed expression is not clonally transmitted during early Drosophila development
94. A new method for predicting signal sequence cleavage sites
95. PATMAT: a searching and extraction program for sequence, pattern and block queries and databases
96. Patterns of engrailed and fushi tarazu transcripts reveals novel intermediate stages in Drosophila segmentation
97. Looking at embryos
98. Pattern formation in the embryo and imaginal discs of Drosophila: what are the links?