The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors

Cell

Volumn 70, Issue 3, 1992, Pages 389-399

  Ridley, Anne J ^a   Hall, Alan ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; GROWTH FACTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; LYSOPHOSPHOLIPID; PHOSPHOLIPASE;

ARTICLE; CELL ACTIVITY; CELL STRAIN 3T3; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; IMMUNOFLUORESCENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN METABOLISM; SERUM;

3T3 CELLS; ACTINS; ANIMAL; AUTORADIOGRAPHY; BLOOD; CELL ADHESION; CELL MEMBRANE; CYTOSKELETON; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE; GROWTH SUBSTANCES; GTP-BINDING PROTEINS; MICE; PHOSPHOLIPIDS; SUPPORT, NON-U.S. GOV'T; VINCULIN;

EID: 0026778133     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(92)90163-7     Document Type: Article

References (53)

1. The rho gene product expressed in E. coli is a substrate for botulinum ADP-ribosyltransferase C3
2. Small GTP-binding proteins in vesicular transport
3. Are lysophosphatidic acids or phosphatidic acids involved in stimulus activation coupling in platelets?
4. Regulation of cytoskeletal architecture by platelet-derived growth factor, insulin and epidermal growth factor
5. The ras gene family and human carcinogenesis
6. Microfilament structure and function in the cortical cytoskeleton
7. Focal adhesions: transmembrane junctions between the extracellular matrix and the cytoskeleton
8. The mammalian G protein rhoC is ADP-ribosylated by Clostridium botulinum exoenzyme C3 and affects actin microfilaments in Vero cells
9. Mitogenic activity of blood components. I. Thrombin and prothrombin
10. Evidence for an actin-containing precursor of the focal contact and the timing of incorporation of vinculin at the focal contact
11. Accumulation of talin in nodes at the edge of the lamellipodium and separate incorporation into adhesion plaques at focal contacts in fibroblasts
12. Chemotaxis in eukaryotic cells: a focus on leukocytes and Dictyostelium
13. Rac, a novel ras-related family of proteins that are botulinum toxin substrates
14. Bcr encodes a GTPase activating protein for p21rac
15. The ras superfamily of small GTP-binding proteins
16. Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the rho proteins, ras p21-like small GTP-binding proteins
17. Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins
18. rho GTPase activating protein, rho-GAP
19. 32P-labelling of phosphatidic acid
20. Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin
21. 2+-independent F-actin assembly and disassembly during Fc receptor-mediated phagocytosis in mouse macrophages
22. The cellular function of small GTP-binding proteins
23. N-ras
24. Identification of actin nucleation activity and polymerization inhibitor in ameboid cells: their regulation by chemotactic stimulation
25. Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells
26. Both stimulatory and inhibitory GDP/GTP exchange proteins, smgGDS and rhoGDI, are active on multiple small GTP-binding proteins
27. Partial purification and characterization of GDP dissociation stimulator (GDS) for the rho proteins from bovine brain cytosol
28. 2+-mobilizing stimulus for fibroblasts
29. Changes in the cytoskeletal structure of human platelets following thrombin activation
30. Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity
31. Insulin-like growth factors, insulin and epidermal growth factor cause rapid cytoskeletal reorganization in KB cells
32. Human ADP-ribosylation factors
33. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
34. The phosphatidylinositol cycle and the regulation of arachidonic acid production
35. The effect of platelet-derived growth factor on morphology and motility of human glial cells
36. Induction of circular membrane ruffling on human fibroblasts by platelet-derived growth factor
37. A stimulatory GDP/GTP exchange protein for smg p21 is active on the post-translationally processed form of c-Ki-ras p21 and rhoA p21
38. rho induces rapid changes in cell morphology
39. The small GTP-binding protein Rac regulates growth factor-induced membrane ruffling
40. Functional modification of a 21-kilodalton G protein when ADP-ribosylated by exoenzyme C3 of Clostridium botulinum
41. Cytokinesis in animal cells
42. Asparagine residue in the rho gene product is the modification site for botulinum ADP-ribosyltransferase
43. ADP-ribosylation factor is a subunit of the coat of Golgi-derived COP-coated vesicles: a novel role for a GTP-binding protein
44. Is a rise in intracellular concentration of free calcium necessary or sufficient for stimulated cytoskeletal-associated actin?
45. Molecular cloning of the gene for the human placental GTP-binding protein Gp (G25K): identification of this GTP-binding protein as the human homolog of the yeast cell-division-cycle protein CDC42
46. The actin cytoskeleton
47. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
48. From signal to pseudopod
49. Transport of lysolecithin by albumin in human and rat plasma
50. Inhibition by phospholipids of the interaction between R-ras, rho and their GTPase-activating proteins
51. Transmembrane molecular assemblies in cell-extracellular matrix interactions
52. Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins
53. Reorganization of actin filament bundles in living fibroblasts