Pharmacokinetics of alfuzosin after single oral administration to healthy volunteers, of three different doses

Biopharmaceutics & Drug Disposition

Volumn 13, Issue 8, 1992, Pages 583-590

  Salva, P ^a   Bianchetti, G ^b   Morselli, P ^b   Garcia Teresa G ^a   Costa, J ^a  

^a HOSPITAL UNIVERSITARI GERMANS TRIAS I PUJOL   (Spain)

^b SANOFI   (France)

Author keywords

Alfuzosin; alpha 1 adrenoceptor antagonist; Healthy Volunteers; Pharmacokinetics

Indexed keywords

ALFUZOSIN; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT;

ADULT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; HEADACHE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MALAISE; MALE; NAUSEA; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; ORTHOSTATIC HYPERTENSION; PHARMACOKINETICS; VOLUNTEER;

ADMINISTRATION, ORAL; ADRENERGIC ALPHA-ANTAGONISTS; ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMAN; MALE; QUINAZOLINES; RANDOM ALLOCATION; REFERENCE VALUES;

EID: 0026774691     PISSN: 01422782     EISSN: 1099081X     Source Type: Journal    
DOI: 10.1002/bdd.2510130804     Document Type: Article

References (6)

1. 1‐adrenoceptor antagonist properties
2. Alfuzosin (SL 77. 499), a new antihypertensive agent with a peripheral site of action: I. In vivo pharmacological studies
3. Bioavailability of diltiazem as a function of the administered dose
4. Disposition of propranolol V. Drug accumulation and steady‐state concentrations during chronic oral administration in man
5. High performance liquid chromatographic determination of alfuzosin in biological fluids with fluorimetric detection and large‐volume injection
6. An interactive graphic program for individual and population pharmacokinetic parameter estimation